ENSMUSG00000028164


Mus musculus

Features
Gene ID: ENSMUSG00000028164
  
Biological name :Manba
  
Synonyms : Manba / mannosidase beta
  
Possible biological names infered from orthology : O00462
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G3
Gene start: 135485611
Gene end: 135571404
  
Corresponding Affymetrix probe sets: 10496302 (MoGene1.0st)   1450626_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029814
Ensembl peptide - ENSMUSP00000122148
NCBI entrez gene - 110173     See in Manteia.
MGI - MGI:88175
RefSeq - NM_027288
RefSeq - XM_006500908
RefSeq Peptide - NP_081564
swissprot - D6RGR1
swissprot - A0A0R4J092
Ensembl - ENSMUSG00000028164
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 manbaENSDARG00000008238Danio rerio
 MANBAENSGALG00000012308Gallus gallus
 MANBAENSG00000109323Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006103  Glycoside hydrolase family 2, catalytic domain
 IPR006104  Glycosyl hydrolases family 2, sugar binding domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR017853  Glycoside hydrolase superfamily
 IPR036156  Beta-Galactosidase/glucuronidase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds IEA
 molecular_functionGO:0004567 beta-mannosidase activity IEA
 molecular_functionGO:0005537 mannose binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Lysosomal oligosaccharide catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0000798 abnormal frontal lobe morphology "malformation or absence of the anterior part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0000815 abnormal ammon gyrus morphology "malformations of one of the two interlocking gyri of the hippocampus; a circonvolution of rhinencephalon, the grey substance of which is rich in big pyramidal neuronal cells " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0000818 abnormal amygdala morphology "any malformation or absence of the almond-shaped body of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe; this area is involved in aggression and fear responses" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0000820 abnormal choroid plexus morphology "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0003172 abnormal lysosome physiology "ability of lysosomes to produce enzymes necessary for digestion of exogenous material is impaired" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0003271 abnormal duodenum morphology "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0004696 abnormal thyroid follicle morphology "any structural abnormality of the small spherical vesicular components of the thyroid gland that are lined with epithelium and contain a colloid substance that both serves as a reservoir of materials for thyroid hormone production and stores thyroid hormones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0004933 abnormal epididymis epithelium morphology "any structural anomaly of the layer of secretory cells which lines the epididymis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0008114 abnormal Kupffer cell morphology "any structural anomaly of the phagocytic macrophages residing on the luminal surface of the hepatic sinusoids" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0009969 abnormal cerebral cortex pyramidal cell morphology "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0009979 abnormal cerebellum deep nucleus morphology "any structural anomaly of the gray matter nuclei located in the center of the cerebellum, embedded in the white matter, which receive inhibitory (GABAergic) inputs from Purkinje cells in the cerebellar cortex and excitatory (glutamatergic) inputs from mossy fiber pathways; all output fibers of the cerebellum originate from the these nuclei" [http://www.spiritus-temporis.com/cerebellum/anatomy.html]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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