Manteia - Molecule gene

ENSMUSG00000028165

Mus musculus

Features

Gene ID:	ENSMUSG00000028165

Biological name :	Cisd2

Synonyms :	CDGSH iron-sulfur domain-containing protein 2 / Cisd2 / Q9CQB5

Possible biological names infered from orthology :	CDGSH iron sulfur domain 2 / Q8N5K1

Species:	Mus musculus

Chr. number:	3
Strand:	-1
Band:	G3
Gene start:	135406412
Gene end:	135423925

Corresponding Affymetrix probe sets:	10502329 (MoGene1.0st) 1428441_at (Mouse Genome 430 2.0 Array) 1429283_at (Mouse Genome 430 2.0 Array) 1430992_s_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000113842 Ensembl peptide - ENSMUSP00000029815 NCBI entrez gene - 67006 See in Manteia. MGI - MGI:1914256 RefSeq - NM_025902 RefSeq - XM_006501918 RefSeq Peptide - NP_080178 swissprot - D3Z3X4 swissprot - Q9CQB5 Ensembl - ENSMUSG00000028165

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
cisd2	ENSDARG00000052703	Danio rerio
CISD2	ENSGALG00000027860	Gallus gallus
CISD2	ENSG00000145354	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Cisd1 / Q91WS0 / CDGSH iron-sulfur domain-containing protein 1 / Q9NZ45* / CDGSH iron sulfur domain 1*	ENSMUSG00000037710	42

Protein motifs (from Interpro)

Interpro ID	Name
IPR018967	Iron sulphur-containing domain, CDGSH-type
IPR019610	Iron sulphur domain-containing, mitoNEET, N-terminal

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000422	autophagy of mitochondrion	IMP
biological_process	GO:0006914	autophagy	IEA
biological_process	GO:0010259	multicellular organism aging	IMP
biological_process	GO:0010506	regulation of autophagy	IEA
cellular_component	GO:0005739	mitochondrion	IEA
cellular_component	GO:0005741	mitochondrial outer membrane	IEA
cellular_component	GO:0005783	endoplasmic reticulum	ISO
cellular_component	GO:0005789	endoplasmic reticulum membrane	ISO
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0032991	protein-containing complex	IEA
cellular_component	GO:0043231	intracellular membrane-bounded organelle	IEA
cellular_component	GO:0048471	perinuclear region of cytoplasm	ISO
molecular_function	GO:0042803	protein homodimerization activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0051536	iron-sulfur cluster binding	IEA
molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000021	prominent ears	"protuberant outer ears" [J:61768]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Cisd2^tm1Tfts/Cisd2⁺ Genetic Background: B6.129S7-Cisd2^tm1Tfts Allelic Composition: Cisd2^{tm1a(EUCOMM)Wtsi}/Cisd2^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cisd2^{tm1a(EUCOMM)Wtsi}/H
MP:0000160	kyphosis	"forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0000162	lordosis	"anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0000379	reduced hair follicle number	"fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0000420	ruffled hair	"fuzzy, irregular appearance of the hair" [J:50844]	Show Allelic Composition: Cisd2^{Gt(XS0445)Wtsi}/Cisd2^{Gt(XS0445)Wtsi} Genetic Background: B6.129P2-Cisd2^{Gt(XS0445)Wtsi}
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cisd2^{Gt(XS0445)Wtsi}/Cisd2^{Gt(XS0445)Wtsi} Genetic Background: B6.129P2-Cisd2^{Gt(XS0445)Wtsi}
MP:0000746	weakness	"state of being infirm or less strong than littermates" [J:45400]	Show Allelic Composition: Cisd2^{Gt(XS0445)Wtsi}/Cisd2^{Gt(XS0445)Wtsi} Genetic Background: B6.129P2-Cisd2^{Gt(XS0445)Wtsi}
MP:0000749	muscle degeneration	"pathological deterioration of muscle tissue, often accompanied by loss of function" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0000759	abnormal skeletal muscle morphology	"anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cisd2^{Gt(XS0445)Wtsi}/Cisd2^{Gt(XS0445)Wtsi} Genetic Background: B6.129P2-Cisd2^{Gt(XS0445)Wtsi}
MP:0000921	demyelination	"loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0001219	thickened epidermis	"increase in the width of the epidermal cell layer in the skin" [J:65146]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Cisd2^{Gt(XS0445)Wtsi}/Cisd2^{Gt(XS0445)Wtsi} Genetic Background: B6.129P2-Cisd2^{Gt(XS0445)Wtsi} Allelic Composition: Cisd2^{tm1a(EUCOMM)Wtsi}/Cisd2^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cisd2^{tm1a(EUCOMM)Wtsi}/H
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0001314	corneal opacity	"complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0001330	abnormal optic nerve morphology	"malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Cisd2^{tm1a(EUCOMM)Wtsi}/Cisd2^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cisd2^{tm1a(EUCOMM)Wtsi}/H
MP:0001566	hyperphosphatemia	"abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cisd2^{tm1a(EUCOMM)Wtsi}/Cisd2^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cisd2^{tm1a(EUCOMM)Wtsi}/H
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0002001	blindness	"loss of the sense of sight" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0002075	abnormal coat color	"irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0002078	abnormal glucose homeostasis	"anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Cisd2^{tm1a(EUCOMM)Wtsi}/Cisd2^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cisd2^{tm1a(EUCOMM)Wtsi}/H
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Cisd2^tm1Tfts/Cisd2⁺ Genetic Background: B6.129S7-Cisd2^tm1Tfts
MP:0002229	CNS neurodegeneration	"a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0002327	abnormal respiratory function	"anomaly in any measure of the processes involved in respiration" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0002644	decreased circulating triglyceride level	"lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Cisd2^{tm1a(EUCOMM)Wtsi}/Cisd2^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cisd2^{tm1a(EUCOMM)Wtsi}/H
MP:0002697	abnormal eye size	"anomalous bulk of the organ of vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cisd2^{tm1a(EUCOMM)Wtsi}/Cisd2^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cisd2^{tm1a(EUCOMM)Wtsi}/H
MP:0002750	exophthalmos	"protrusion of one or both eyeballs" [J:47965, il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0002834	decreased heart weight	"less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Cisd2^{tm1a(EUCOMM)Wtsi}/Cisd2^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cisd2^{tm1a(EUCOMM)Wtsi}/H
MP:0002841	impaired skeletal muscle contractility	"inability or reduced ability of the skeletal muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Cisd2^{Gt(XS0445)Wtsi}/Cisd2^{Gt(XS0445)Wtsi} Genetic Background: B6.129P2-Cisd2^{Gt(XS0445)Wtsi}
MP:0002891	increased insulin sensitivity	"greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0002896	abnormal bone mineralization	"defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cisd2^{tm1a(EUCOMM)Wtsi}/Cisd2^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cisd2^{tm1a(EUCOMM)Wtsi}/H
MP:0003059	decreased insulin secretion	"less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0003084	abnormal skeletal muscle fiber morphology	"anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cisd2^{Gt(XS0445)Wtsi}/Cisd2^{Gt(XS0445)Wtsi} Genetic Background: B6.129P2-Cisd2^{Gt(XS0445)Wtsi}
MP:0003620	decreased urine output	"decreased volume of urine produced and excreted" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0003786	premature aging	"earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Cisd2^tm1Tfts/Cisd2^tm1Tfts Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003866	abnormal defecation	"anomaly in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0003961	decreased lean body mass	"less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Cisd2^{tm1a(EUCOMM)Wtsi}/Cisd2^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cisd2^{tm1a(EUCOMM)Wtsi}/H
MP:0004087	abnormal muscle fiber morphology	"malformed or poorly developed muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0004089	dilated sarcoplasmic reticulum	"an expansion in the volume in the endoplasmic reticulum of skeletal and cardiac muscle, i.e. the complex of vesicles, tubules, and cisternae that form a continuous structure around striated myofibrils, with a repetition of structure within each sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Cisd2^{Gt(XS0445)Wtsi}/Cisd2^{Gt(XS0445)Wtsi} Genetic Background: B6.129P2-Cisd2^{Gt(XS0445)Wtsi}
MP:0004090	abnormal sarcomere morphology	"any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Cisd2^{Gt(XS0445)Wtsi}/Cisd2^{Gt(XS0445)Wtsi} Genetic Background: B6.129P2-Cisd2^{Gt(XS0445)Wtsi}
MP:0004231	abnormal calcium ion homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cisd2^{Gt(XS0445)Wtsi}/Cisd2^{Gt(XS0445)Wtsi} Genetic Background: B6.129P2-Cisd2^{Gt(XS0445)Wtsi}
MP:0004734	small thoracic cavity	"reduced size of the cavity in the vertebrate body enclosed by the ribcage between the diaphragm and the neck, and contains the lungs, heart, thoracic aorta, pulmonary artery and its branches, thymus gland, and the respiratory airway" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0004924	abnormal behavior	"anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cisd2^{tm1a(EUCOMM)Wtsi}/Cisd2^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cisd2^{tm1a(EUCOMM)Wtsi}/H
MP:0005202	lethargy	"mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cisd2^{Gt(XS0445)Wtsi}/Cisd2^{Gt(XS0445)Wtsi} Genetic Background: B6.129P2-Cisd2^{Gt(XS0445)Wtsi}
MP:0005290	decreased oxygen consumption	"less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0005293	impaired glucose tolerance	"less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0005329	abnormal cardiac muscle morphology	"anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0005343	increased circulating aspartate transaminase level	"greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]	Show Allelic Composition: Cisd2^{tm1a(EUCOMM)Wtsi}/Cisd2^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cisd2^{tm1a(EUCOMM)Wtsi}/H
MP:0005405	axon degeneration	"retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0005586	decreased tidal volume	"less than the normal volume of air inspired or expired during each normal respiratory cycle" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0006035	abnormal mitochondrial morphology	"anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0006086	decreased body mass index	"less than normal average of a measure of weight for height " [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0008260	abnormal autophagy	"abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cisd2^{Gt(XS0445)Wtsi}/Cisd2^{Gt(XS0445)Wtsi} Genetic Background: B6.129P2-Cisd2^{Gt(XS0445)Wtsi}
MP:0008805	decreased circulating amylase level	"reduction in the concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cisd2^{tm1a(EUCOMM)Wtsi}/Cisd2^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cisd2^{tm1a(EUCOMM)Wtsi}/H
MP:0008844	decreased subcutaneous adipose tissue amount	"reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0008852	retinal neovascularization	"formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina" [MESH:C11.768.725]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0009346	decreased cancellous bone thickness	"thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0009409	abnormal skeletal muscle fiber type ratio	"deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cisd2^{Gt(XS0445)Wtsi}/Cisd2^{Gt(XS0445)Wtsi} Genetic Background: B6.129P2-Cisd2^{Gt(XS0445)Wtsi}
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0010955	abnormal respiratory electron transport chain	"anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0011630	increased mitochondria size	"enlarged the cellular organelles responsible for energy production" [MGI:csmith]	Show Allelic Composition: Cisd2^{Gt(XS0445)Wtsi}/Cisd2^{Gt(XS0445)Wtsi} Genetic Background: B6.129P2-Cisd2^{Gt(XS0445)Wtsi}
MP:0011633	abnormal mitochondrial shape	"any anomaly in the characteristic surface outline or contour of a mitochondria" [MGI:csmith]	Show Allelic Composition: Cisd2^{Gt(XS0445)Wtsi}/Cisd2^{Gt(XS0445)Wtsi} Genetic Background: B6.129P2-Cisd2^{Gt(XS0445)Wtsi}
MP:0011635	abnormal mitochondrial crista morphology	"Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061]	Show Allelic Composition: Cisd2^{Gt(XS0445)Wtsi}/Cisd2^{Gt(XS0445)Wtsi} Genetic Background: B6.129P2-Cisd2^{Gt(XS0445)Wtsi}
MP:0011940	decreased food intake	"reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0011942	decreased fluid intake	"reduction in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Cltrn^tm1Thu/Y Genetic Background: involves: 129S/SvEv * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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