ENSMUSG00000028264


Mus musculus

Features
Gene ID: ENSMUSG00000028264
  
Biological name :Spaca1
  
Synonyms : Q9DA48 / Spaca1 / sperm acrosome associated 1
  
Possible biological names infered from orthology : Q9HBV2
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A5
Gene start: 34024874
Gene end: 34050191
  
Corresponding Affymetrix probe sets: 10511939 (MoGene1.0st)   1429571_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029927
Ensembl peptide - ENSMUSP00000103783
Ensembl peptide - ENSMUSP00000081785
NCBI entrez gene - 67652     See in Manteia.
MGI - MGI:1914902
RefSeq - NM_026293
RefSeq - NM_001290443
RefSeq Peptide - NP_001277372
RefSeq Peptide - NP_080569
swissprot - Q9DA48
swissprot - B1AWF1
swissprot - B1AWF0
swissprot - B1AWF2
Ensembl - ENSMUSG00000028264
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SPACA1ENSGALG00000043839Gallus gallus
 Q9HBV2ENSG00000118434Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001675 acrosome assembly IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0016998 cell wall macromolecule catabolic process IBA
 biological_processGO:0050829 defense response to Gram-negative bacterium IBA
 biological_processGO:0050830 defense response to Gram-positive bacterium IBA
 cellular_componentGO:0002079 inner acrosomal membrane IEA
 cellular_componentGO:0002080 acrosomal membrane IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0003796 lysozyme activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

Allelic Composition: Spaca1tm1.1Osb/Spaca1tm1.1Osb,Tg(Acr-EGFP)1Osb/0
Genetic Background: involves: 129S2/SvPas * C3H * C57BL * C57BL/6 * DBA

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spaca1tm1.1Osb/Spaca1tm1.1Osb,Tg(Acr-EGFP)1Osb/0
Genetic Background: involves: 129S2/SvPas * C3H * C57BL * C57BL/6 * DBA

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

 MP:0008898 abnormal acrosome morphology "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]
Show

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

Allelic Composition: Spaca1tm1.1Osb/Spaca1tm1.1Osb,Tg(Acr-EGFP)1Osb/0
Genetic Background: involves: 129S2/SvPas * C3H * C57BL * C57BL/6 * DBA

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

 MP:0009238 coiled sperm flagellum "abnormal twisting of the sperm flagellum into coils or spirals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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