ENSMUSG00000028333


Mus musculus

Features
Gene ID: ENSMUSG00000028333
  
Biological name :Anp32b
  
Synonyms : Acidic leucine-rich nuclear phosphoprotein 32 family member B / Anp32b / Q9EST5
  
Possible biological names infered from orthology : acidic nuclear phosphoprotein 32 family member B / Q92688
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: B1
Gene start: 46450902
Gene end: 46472657
  
Corresponding Affymetrix probe sets: 10504730 (MoGene1.0st)   1417082_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099990
NCBI entrez gene - 67628     See in Manteia.
MGI - MGI:1914878
RefSeq - NM_130889
RefSeq - XM_011250089
RefSeq Peptide - NP_570959
swissprot - Q9EST5
Ensembl - ENSMUSG00000028333
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 anp32bENSDARG00000023330Danio rerio
 ANP32BENSG00000136938Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O35381 / Anp32a / Acidic leucine-rich nuclear phosphoprotein 32 family member A / P39687* / ANP32D* / O95626* / acidic nuclear phosphoprotein 32 family member A* / acidic nuclear phosphopr...ENSMUSG0000003224960
Anp32e / P97822 / Acidic leucine-rich nuclear phosphoprotein 32 family member E / Q9BTT0* / acidic nuclear phosphoprotein 32 family member E*ENSMUSG0000001574953


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR003603  U2A"/phosphoprotein 32 family A, C-terminal
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle ISO
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0006334 nucleosome assembly IEA
 biological_processGO:0006913 nucleocytoplasmic transport IBA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0021591 ventricular system development IMP
 biological_processGO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process IBA
 biological_processGO:0043486 histone exchange IBA
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0046827 positive regulation of protein export from nucleus IEA
 biological_processGO:0048839 inner ear development IMP
 biological_processGO:0060021 roof of mouth development IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0070063 RNA polymerase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000026 abnormal inner ear morphology "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
Show

Allelic Composition: Rag2tm1.1Mss/Rag2tm1.1Mss,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: B6.129P2-Anp32btm1Mak

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Rag2tm1.1Mss/Rag2tm1.1Mss,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: B6.129P2-Anp32btm1Mak

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rag2tm1.1Mss/Rag2tm1.1Mss,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: C.129P2(B6)-Anp32btm1Mak

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rag2tm1.1Mss/Rag2tm1.1Mss,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: B6.129P2-Anp32btm1Mak

 MP:0000536 hydroureter "distention of the ureter with urine, due to blockage from any cause" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:Cml, J:13044]
Show

Allelic Composition: Rag2tm1.1Mss/Rag2tm1.1Mss,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Rag2tm1.1Mss/Rag2tm1.1Mss,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: C.129P2(B6)-Anp32btm1Mak

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Rag2tm1.1Mss/Rag2tm1.1Mss,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rag2tm1.1Mss/Rag2tm1.1Mss,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: C.129P2(B6)-Anp32btm1Mak

 MP:0002731 megacolon "extreme dilation of the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:40722]
Show

Allelic Composition: Rag2tm1.1Mss/Rag2tm1.1Mss,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0003786 premature aging "earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]
Show

Allelic Composition: Rag2tm1.1Mss/Rag2tm1.1Mss,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0004025 polyploidy "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Rag2tm1.1Mss/Rag2tm1.1Mss,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: C.129P2(B6)-Anp32btm1Mak

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: C.129P2(B6)-Anp32btm1Mak

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: C.129P2(B6)-Anp32btm1Mak

 MP:0005635 decreased circulating bilirubin level "less thant the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: C.129P2(B6)-Anp32btm1Mak

 MP:0008817 hematoma "an abnormal localized accumulation of clotted or partially clotted blood in an organ or a soft tissue space as a result of localized hemorrhage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rag2tm1.1Mss/Rag2tm1.1Mss,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0010819 primary atelectasis "nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Rag2tm1.1Mss/Rag2tm1.1Mss,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: B6.129P2-Anp32btm1Mak

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: C.129P2(B6)-Anp32btm1Mak

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: FVB.129P2(B6)-Anp32btm1Mak

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Rag2tm1.1Mss/Rag2tm1.1Mss,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: B6.129P2-Anp32btm1Mak

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: B6.129P2-Anp32btm1Mak

Allelic Composition: Anp32atm1Mak/Anp32a+,Anp32btm1Mak/Anp32btm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Anp32atm1Mak/Anp32atm1Mak,Anp32btm1Mak/Anp32btm1Mak,Anp32etm1Mak/Anp32etm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Anp32atm1Mak/Anp32atm1Mak,Anp32btm1Mak/Anp32btm1Mak,Anp32etm1Mak/Anp32e+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Anp32atm1Mak/Anp32a+,Anp32btm1Mak/Anp32btm1Mak,Anp32etm1Mak/Anp32etm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Anp32atm1Mak/Anp32a+,Anp32btm1Mak/Anp32btm1Mak,Anp32etm1Mak/Anp32e+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Anp32atm1Mak/Anp32a+,Anp32btm1Mak/Anp32btm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
Show

Allelic Composition: Rag2tm1.1Mss/Rag2tm1.1Mss,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: B6.129P2-Anp32btm1Mak

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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