ENSMUSG00000028351


Mus musculus

Features
Gene ID: ENSMUSG00000028351
  
Biological name :Brinp1
  
Synonyms : BMP/retinoic acid-inducible neural-specific protein 1 / Brinp1 / Q920P3
  
Possible biological names infered from orthology : BMP/retinoic acid inducible neural specific 1 / O60477
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C1
Gene start: 68761514
Gene end: 68954397
  
Corresponding Affymetrix probe sets: 10513805 (MoGene1.0st)   1417318_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030036
NCBI entrez gene - 56710     See in Manteia.
MGI - MGI:1928478
RefSeq - NM_019967
RefSeq Peptide - NP_064351
swissprot - Q920P3
Ensembl - ENSMUSG00000028351
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 brinp1ENSDARG00000078302Danio rerio
 BRINP1ENSGALG00000006997Gallus gallus
 BRINP1ENSG00000078725Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Brinp3 / Q499E0 / Mus musculus bone morphotic protein/retinoic acid inducible neural specific 3 (Brinp3), transcript variant 4, mRNA. / Q76B58* / BMP/retinoic acid inducible neural specific 3*ENSMUSG0000003513153
Brinp2 / Q6DFY8 / BMP/retinoic acid-inducible neural-specific protein 2 / Q9C0B6* / BMP/retinoic acid inducible neural specific 2*ENSMUSG0000000403152


Protein motifs (from Interpro)
Interpro ID Name
 IPR020864  Membrane attack complex component/perforin (MACPF) domain
 IPR033237  BMP/retinoic acid-inducible neural-specific protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007614 short-term memory IMP
 biological_processGO:0008219 cell death IEA
 biological_processGO:0035176 social behavior IMP
 biological_processGO:0035640 exploration behavior IMP
 biological_processGO:0042711 maternal behavior IMP
 biological_processGO:0045666 positive regulation of neuron differentiation IDA
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0045930 negative regulation of mitotic cell cycle IDA
 biological_processGO:0050768 negative regulation of neurogenesis IMP
 biological_processGO:0071300 cellular response to retinoic acid IDA
 biological_processGO:0071625 vocalization behavior IMP
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0030425 dendrite IBA
 cellular_componentGO:0043025 neuronal cell body IBA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1tm1.1Pib
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Ntrk1tm1.1Azmo/Ntrk1tm1.1Azmo
Genetic Background: involves: 129S2/SvPas

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ntrk1tm1.1Azmo/Ntrk1tm1.1Azmo
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Brinp1tm1.1Pib/Brinp1tm1.1Pib
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk1tm1.1Azmo/Ntrk1tm1.1Azmo
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Brinp1tm1.1Pib/Brinp1tm1.1Pib
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
Show

Allelic Composition: Ntrk1tm1.1Azmo/Ntrk1tm1.1Azmo
Genetic Background: involves: 129S2/SvPas

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Ntrk1tm1.1Azmo/Ntrk1tm1.1Azmo
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Brinp1tm1.1Pib/Brinp1tm1.1Pib
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntrk1tm1.1Azmo/Ntrk1tm1.1Azmo
Genetic Background: involves: 129S2/SvPas

 MP:0001408 stereotypic behavior "repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s wrong with my mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1tm1.1Pib
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0001442 decreased grooming behavior "reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1tm1.1Pib
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0001529 abnormal vocalization "an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:85479]
Show

Allelic Composition: Dio3tm1Dmst/Dio3tm1Dmst,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1tm1.1Pib
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1tm1.1Pib
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk1tm1.1Azmo/Ntrk1tm1.1Azmo
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Brinp1tm1.1Pib/Brinp1tm1.1Pib
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0004980 increased neuronal precursor cell number "increased number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk1tm1.1Azmo/Ntrk1tm1.1Azmo
Genetic Background: involves: 129S2/SvPas

 MP:0008263 abnormal hippocampus CA1 region morphology 
Show

Allelic Composition: Ntrk1tm1.1Azmo/Ntrk1tm1.1Azmo
Genetic Background: involves: 129S2/SvPas

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk1tm1.1Azmo/Ntrk1tm1.1Azmo
Genetic Background: involves: 129S2/SvPas

 MP:0008431 abnormal short-term spatial reference memory "anomaly in the short-term memory for spatial location information that is established during the first few minutes after training or an encouter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1tm1.1Pib
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1tm1.1Pib
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1tm1.1Pib
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1tm1.1Pib
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1tm1.1Pib
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0011827 impaired neuron differentiation "decreased production of or inability to produce the mature cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith]
Show

Allelic Composition: Ntrk1tm1.1Azmo/Ntrk1tm1.1Azmo
Genetic Background: involves: 129S2/SvPas

 MP:0013189 abnormal exploration in a new environment "anomaly in the amount of time spent investigating new location" [MPD:Molly]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1tm1.1Pib
Genetic Background: involves: BALB/cJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr