ENSMUSG00000028373


Mus musculus

Features
Gene ID: ENSMUSG00000028373
  
Biological name :Astn2
  
Synonyms : Astn2 / Astrotactin-2 / Q80Z10
  
Possible biological names infered from orthology : O75129
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C1
Gene start: 65380803
Gene end: 66404611
  
Corresponding Affymetrix probe sets: 10513776 (MoGene1.0st)   1450309_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000065786
Ensembl peptide - ENSMUSP00000081540
NCBI entrez gene - 56079     See in Manteia.
MGI - MGI:1889277
RefSeq - XM_006538105
RefSeq - NM_019514
RefSeq - NM_207109
RefSeq - XM_006538104
RefSeq Peptide - NP_062387
RefSeq Peptide - NP_996992
swissprot - Q80Z10
Ensembl - ENSMUSG00000028373
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01075572.1ENSDARG00000105924Danio rerio
 ASTN2ENSGALG00000007038Gallus gallus
 ASTN2ENSG00000148219Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Astn1 / Q61137 / Astrotactin-1 / O14525*ENSMUSG0000002658747


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013783  Immunoglobulin-like fold
 IPR020864  Membrane attack complex component/perforin (MACPF) domain
 IPR026995  Astrotactin
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0048105 establishment of body hair planar orientation IGI
 biological_processGO:2000009 negative regulation of protein localization to cell surface IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IDA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0060187 cell pole IDA
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043533 inositol 1,3,4,5 tetrakisphosphate binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
Show

Allelic Composition: Astn2tm1.2Nat/Astn2tm1.2Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129S6/SvEvTac * BALB/cJ * C57BL/6 * CBA

Allelic Composition: Astn2ridge/Astn2ridge,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

 MP:0002074 abnormal hair texture "irregular or unusual appearance of the structure of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Thap1tm1.1Meeh/Thap1tm1.2Meeh
Genetic Background: involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6

Allelic Composition: Astn2ridge/Astn2ridge,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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