ENSMUSG00000028381


Mus musculus

Features
Gene ID: ENSMUSG00000028381
  
Biological name :Ugcg
  
Synonyms : O88693 / UDP-glucose ceramide glucosyltransferase / Ugcg
  
Possible biological names infered from orthology : Q16739
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: B3
Gene start: 59189257
Gene end: 59222833
  
Corresponding Affymetrix probe sets: 10505187 (MoGene1.0st)   1421268_at (Mouse Genome 430 2.0 Array)   1421269_at (Mouse Genome 430 2.0 Array)   1435133_at (Mouse Genome 430 2.0 Array)   1439863_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030074
NCBI entrez gene - 22234     See in Manteia.
MGI - MGI:1332243
RefSeq - NM_011673
RefSeq - XM_006537785
RefSeq Peptide - NP_035803
swissprot - O88693
Ensembl - ENSMUSG00000028381
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ugcgENSDARG00000058221Danio rerio
 UGCGENSGALG00000015682Gallus gallus
 UGCGENSG00000148154Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR025993  Ceramide glucosyltransferase
 IPR029044  Nucleotide-diphospho-sugar transferases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006665 sphingolipid metabolic process IEA
 biological_processGO:0006679 glucosylceramide biosynthetic process IBA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IBA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008120 ceramide glucosyltransferase activity IBA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0102769 dihydroceramide glucosyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Glycosphingolipid metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Ugcgtm4Rlp/Ugcgtm4Rlp,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Ugcgtm1Rlp/Ugcgtm4Rlp,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: C57BL/6J * CBA/CaGr

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: C57BL/6J * CBA/CaGr

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: C57BL/6J * CBA/CaGr

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: C57BL/6J * CBA/CaGr

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: C57BL/6J * CBA/CaGr

Allelic Composition: Ugcgtm4Rlp/Ugcgtm4Rlp,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Ugcgtm1Rlp/Ugcgtm4Rlp,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: C57BL/6J * CBA/CaGr

Allelic Composition: Ugcgtm4Rlp/Ugcgtm4Rlp,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Ugcgtm1Rlp/Ugcgtm4Rlp,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: C57BL/6J * CBA/CaGr

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: C57BL/6J * CBA/CaGr

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax1Un-s/Pax1Un-s
Genetic Background: B6.CC57BR-Pax1Un-s

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gal3st1tm1.1Hjg/Gal3st1tm1.1Hjg,Ugcgtm1Hjg/Ugcgtm1Hjg,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: C57BL/6J * CBA/CaGr

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atmtm1Pmc/Atmtm1Pmc,Trp73tm2Mak/Trp73tm2Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002582 disorganized extraembryonic tissue "a lack of the regular arrangement of the membranes involved with the embryo s protection and nutrition" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0003895 increased ectoderm apoptosis "increase in the number of ectoderm cells undergoing programmed cell death during development" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0003950 abnormal plasma membrane morphology "anomalous structure of the semipermeable membrane that encloses the cytoplasm of a cell" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Pax1Un-s/Pax1Un-s
Genetic Background: B6.CC57BR-Pax1Un-s

 MP:0003954 abnormal Reichert s membrane "aberrant structure of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm beginning at E6.0 and is secreted by the distal endoderm; required for the maternofetal exchange of nutrients and is important for the postgastrulation development" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0004193 abnormal kidney papilla morphology "any structural anomaly of the apex of the renal pyramid that projects into a calyx" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gal3st1tm1.1Hjg/Gal3st1tm1.1Hjg,Ugcgtm1Hjg/Ugcgtm1Hjg,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: C57BL/6J * CBA/CaGr

 MP:0005619 increased potassium excretion "greater than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Gal3st1tm1.1Hjg/Gal3st1tm1.1Hjg,Ugcgtm1Hjg/Ugcgtm1Hjg,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009350 decreased urine pH "increased urine acidity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gal3st1tm1.1Hjg/Gal3st1tm1.1Hjg,Ugcgtm1Hjg/Ugcgtm1Hjg,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ugcgtm1Hjg/Ugcgtm1Hjg,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gal3st1tm1.1Hjg/Gal3st1tm1.1Hjg,Ugcgtm1Hjg/Ugcgtm1Hjg,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: C57BL/6J * CBA/CaGr

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0011736 decreased urine ammonia level "a reduced amount of ammonia in the urine compared to the normal state" [MGI:anna]
Show

Allelic Composition: Gal3st1tm1.1Hjg/Gal3st1tm1.1Hjg,Ugcgtm1Hjg/Ugcgtm1Hjg,Pax8tm1.1(cre)Mbu/Pax8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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