ENSMUSG00000028414


Mus musculus

Features
Gene ID: ENSMUSG00000028414
  
Biological name :Fktn
  
Synonyms : Fktn / Fukutin / Q8R507
  
Possible biological names infered from orthology : O75072
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: B2
Gene start: 53713998
Gene end: 53777890
  
Corresponding Affymetrix probe sets: 10505044 (MoGene1.0st)   1425031_at (Mouse Genome 430 2.0 Array)   1435801_at (Mouse Genome 430 2.0 Array)   1446624_at (Mouse Genome 430 2.0 Array)   1451853_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114699
Ensembl peptide - ENSMUSP00000152154
Ensembl peptide - ENSMUSP00000152867
Ensembl peptide - ENSMUSP00000061489
Ensembl peptide - ENSMUSP00000138774
NCBI entrez gene - 246179     See in Manteia.
MGI - MGI:2179507
RefSeq - XM_017320229
RefSeq - NM_139309
RefSeq - XM_006537941
RefSeq - XM_006537942
RefSeq - XM_006537943
RefSeq - XM_017320228
RefSeq Peptide - NP_647470
swissprot - Q8K4R2
swissprot - Q8R507
swissprot - A0A1Y7VM91
Ensembl - ENSMUSG00000028414
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fktnENSDARG00000059437Danio rerio
 FKTNENSGALG00000015443Gallus gallus
 FKTNENSG00000106692Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007074  LicD family
 IPR009644  Fukutin-related


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration NAS
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0035269 protein O-linked mannosylation ISS
 biological_processGO:0046329 negative regulation of JNK cascade ISO
 biological_processGO:0060049 regulation of protein glycosylation NAS
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005801 cis-Golgi network ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000731 increased collagen deposition in the muscles "accumulation of collagen within the muscles" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1+,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
Show

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000752 dystrophic muscle "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994]
Show

Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1+,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129S/SvEv * FVB

Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

Allelic Composition: Dysfim/Dysfim,Fktntm1Ttd/Fktntm2(FCMD)Ttd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL/J

Allelic Composition: Dysfim/Dysfim,Fktntm2(FCMD)Ttd/Fktn+
Genetic Background: involves: C57BL/6 * SJL/J

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dysfim/Dysfim,Fktntm1Ttd/Fktntm2(FCMD)Ttd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL/J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129S/SvEv * FVB

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0003044 impaired basement membrane formation "defect in the organization and/or placement of the extracellular supportive tissue closely adjacent to the basal surface of the epithelium of muscle cells, fat cells and Schwann cells, which is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

Allelic Composition: Dysfim/Dysfim,Fktntm1Ttd/Fktntm2(FCMD)Ttd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL/J

Allelic Composition: Dysfim/Dysfim,Fktntm2(FCMD)Ttd/Fktn+
Genetic Background: involves: C57BL/6 * SJL/J

 MP:0003085 abnormal egg cylinder morphology "anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0003833 decreased number of satellite cells "less than the normal number of unfused cells in muscle that play a role in muscle regeneration" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0003852 skeletal muscle necrosis "pathological cell death in the skeletal muscle, usually due to irreversible damage" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0003954 abnormal Reichert s membrane "aberrant structure of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm beginning at E6.0 and is secreted by the distal endoderm; required for the maternofetal exchange of nutrients and is important for the postgastrulation development" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0004510 myositis "inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle" [MESH:C05.651.594]
Show

Allelic Composition: Dysfim/Dysfim,Fktntm1Ttd/Fktntm2(FCMD)Ttd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL/J

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

Allelic Composition: Fktntm1Ttd/Fktntm2(FCMD)Ttd
Genetic Background: involves: 129S7/SvEvBrd

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fktntm1Ttd/Fktntm2(FCMD)Ttd
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009403 increased variability of skeletal muscle fiber size "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

Allelic Composition: Dysfim/Dysfim,Fktntm1Ttd/Fktntm2(FCMD)Ttd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL/J

Allelic Composition: Dysfim/Dysfim,Fktntm2(FCMD)Ttd/Fktn+
Genetic Background: involves: C57BL/6 * SJL/J

 MP:0009412 skeletal muscle fiber degeneration "pathological deterioration of skeletal muscle fiber tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dysfim/Dysfim,Fktntm1Ttd/Fktntm2(FCMD)Ttd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL/J

 MP:0009414 skeletal muscle fiber necrosis "pathological cell death in the skeletal muscle fibers, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dysfim/Dysfim,Fktntm2(FCMD)Ttd/Fktn+
Genetic Background: involves: C57BL/6 * SJL/J

 MP:0009417 skeletal muscle atrophy "a wasting of skeletal muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0009419 skeletal muscle fibrosis "formation of fibrous tissue within skeletal muscle as a result of repair or a reactive process" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Dysfim/Dysfim,Fktntm1Ttd/Fktntm2(FCMD)Ttd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL/J

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

 MP:0010090 increased circulating creatine kinase level "an elevation in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1+,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129S/SvEv * FVB

Allelic Composition: Fktntm1Kcam/Fktntm1Kcam,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0010239 decreased skeletal muscle weight "less than average skeletal muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fktntm3.1Ttd/Fktntm3.1Ttd,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1+,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1+,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0011105 partial embryonic lethality between implantation and placentation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0011116 absent Reichert s membrane "absence of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm during placenta morphogenesis and is secreted by the distal endoderm; normally required for the maternofetal exchange of nutrients and important for postgastrulation development" [MGI:anna]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0011191 increased embryonic epiblast cell apoptosis "increase in the number of embryonic epiblast cells undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0011201 abnormal visceral yolk sac cavity morphology "any structural anomaly of the closed space containing the yolk, formed by the fusion of the edges of the embryonic epiblast (hypoblast) and later surrounded by the visceral yolk sac (hypoblast and visceral yolk sac mesoderm)" [ISBN:0-12-402035-6, PMID:21123814]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0012094 abnormal Reichert s membrane thickness "anomaly in the width of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm during placenta morphogenesis and is secreted by the distal parietal endoderm" [MGI:anna]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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