ENSMUSG00000028416


Mus musculus

Features
Gene ID: ENSMUSG00000028416
  
Biological name :Bag1
  
Synonyms : Bag1 / BAG family molecular chaperone regulator 1 / Q60739
  
Possible biological names infered from orthology : BCL2 associated athanogene 1 / Q99933
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A5
Gene start: 40936398
Gene end: 40948294
  
Corresponding Affymetrix probe sets: 10512136 (MoGene1.0st)   1416394_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030125
Ensembl peptide - ENSMUSP00000103724
Ensembl peptide - ENSMUSP00000139864
Ensembl peptide - ENSMUSP00000149606
NCBI entrez gene - 12017     See in Manteia.
MGI - MGI:108047
RefSeq - NM_009736
RefSeq - NM_001171739
RefSeq Peptide - NP_001165210
RefSeq Peptide - NP_033866
swissprot - Q60739
swissprot - A0A1L1SRT0
swissprot - F6TCF9
Ensembl - ENSMUSG00000028416
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bag1ENSDARG00000020895Danio rerio
 BAG1ENSGALG00000013157Gallus gallus
 BAG1ENSG00000107262Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR003103  BAG domain
 IPR017093  Molecular chaperone regulator BAG-1
 IPR029071  Ubiquitin-like domain superfamily
 IPR036533  BAG domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001933 negative regulation of protein phosphorylation IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0030182 neuron differentiation IDA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043525 positive regulation of neuron apoptotic process IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0051085 chaperone cofactor-dependent protein refolding ISO
 biological_processGO:0070585 protein localization to mitochondrion IMP
 biological_processGO:2000672 negative regulation of motor neuron apoptotic process IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000774 adenyl-nucleotide exchange factor activity ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0051087 chaperone binding IEA
 molecular_functionGO:0051219 phosphoprotein binding IPI


Pathways (from Reactome)
Pathway description
Regulation of HSF1-mediated heat shock response


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
Show

Allelic Composition: Notch3tm1Ul/Notch3+
Genetic Background: Not Specified

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Asxl1tm1a(EUCOMM)Wtsi/Asxl1+
Genetic Background: C57BL/6N-Asxl1tm1a(EUCOMM)Wtsi/Cnrm

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Asxl1tm1a(EUCOMM)Wtsi/Asxl1+
Genetic Background: C57BL/6N-Asxl1tm1a(EUCOMM)Wtsi/Cnrm

 MP:0010267 decreased lung tumor incidence "less than the expected number of neoplams in the lung, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Notch3tm1Ul/Notch3+
Genetic Background: Not Specified

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Notch3tm1Ul/Notch3+
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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