ENSMUSG00000028453


Mus musculus

Features
Gene ID: ENSMUSG00000028453
  
Biological name :Fancg
  
Synonyms : Fancg / Fanconi anemia group G protein homolog / Q9EQR6
  
Possible biological names infered from orthology : Fanconi anemia complementation group G / O15287
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A5
Gene start: 43002343
Gene end: 43010506
  
Corresponding Affymetrix probe sets: 10512411 (MoGene1.0st)   1420960_at (Mouse Genome 430 2.0 Array)   1450059_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030165
NCBI entrez gene - 60534     See in Manteia.
MGI - MGI:1926471
RefSeq - XM_017320336
RefSeq - NM_001163233
RefSeq - NM_053081
RefSeq - XM_006538127
RefSeq - XM_006538128
RefSeq Peptide - NP_001156705
RefSeq Peptide - NP_444311
swissprot - Q9EQR6
Ensembl - ENSMUSG00000028453
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fancgENSDARG00000024967Danio rerio
 FANCGENSGALG00000002009Gallus gallus
 FANCGENSG00000221829Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0009314 response to radiation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0043240 Fanconi anaemia nuclear complex IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Ppp1r1btm2Pggd/Ppp1r1btm2Pggd
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fancgtm1Ada/Fancgtm1Ada
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Ppp1r1btm2Pggd/Ppp1r1btm2Pggd
Genetic Background: involves: 129 * C57BL/6

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
Show

Allelic Composition: Ppp1r1btm2Pggd/Ppp1r1btm2Pggd
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fancgtm1Ada/Fancgtm1Ada
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fancgtm1Ada/Fancgtm1Ada
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Ppp1r1btm2Pggd/Ppp1r1btm2Pggd
Genetic Background: involves: 129 * C57BL/6

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
Show

Allelic Composition: Ppp1r1btm2Pggd/Ppp1r1btm2Pggd
Genetic Background: involves: 129 * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Ppp1r1btm2Pggd/Ppp1r1btm2Pggd
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fancgtm1Ada/Fancgtm1Ada
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ppp1r1btm2Pggd/Ppp1r1btm2Pggd
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fancgtm1Ada/Fancgtm1Ada
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Fancgtm1Ada/Fancgtm1Ada
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppp1r1btm2Pggd/Ppp1r1btm2Pggd
Genetic Background: involves: 129 * C57BL/6

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppp1r1btm2Pggd/Ppp1r1btm2Pggd
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fancgtm1Ada/Fancgtm1Ada
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppp1r1btm2Pggd/Ppp1r1btm2Pggd
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fancgtm1Ada/Fancgtm1Ada
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004029 spontaneous chromosome breakage "chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppp1r1btm2Pggd/Ppp1r1btm2Pggd
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fancgtm1Ada/Fancgtm1Ada
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004030 induced chromosome breakage "chromosome breakage following treatment with a DNA-damaging agent " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppp1r1btm2Pggd/Ppp1r1btm2Pggd
Genetic Background: involves: 129 * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fancgtm1Ada/Fancgtm1Ada
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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