Manteia - Molecule gene

ENSMUSG00000028459

Mus musculus

Features

Gene ID:	ENSMUSG00000028459

Biological name :	Cd72

Synonyms :	B-cell differentiation antigen CD72 / Cd72 / P21855

Possible biological names infered from orthology :	CD72 molecule / P21854

Species:	Mus musculus

Chr. number:	4
Strand:	-1
Band:	A5
Gene start:	43446462
Gene end:	43454628

Corresponding Affymetrix probe sets:	10512470 (MoGene1.0st) 1426112_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000095708 Ensembl peptide - ENSMUSP00000103558 Ensembl peptide - ENSMUSP00000103559 Ensembl peptide - ENSMUSP00000030179 Ensembl peptide - ENSMUSP00000095709 NCBI entrez gene - 12517 See in Manteia. MGI - MGI:88345 RefSeq - XM_006537582 RefSeq - NM_001110320 RefSeq - NM_001110321 RefSeq - NM_001110322 RefSeq - NM_007654 RefSeq - XM_006537576 RefSeq - XM_006537577 RefSeq - XM_006537578 RefSeq - XM_006537579 RefSeq - XM_006537580 RefSeq - XM_006537581 RefSeq Peptide - NP_001103792 RefSeq Peptide - NP_031680 RefSeq Peptide - NP_001103790 RefSeq Peptide - NP_001103791 swissprot - Q3UNJ0 swissprot - Q3UB58 swissprot - Q3UZ35 swissprot - A2AIN5 swissprot - P21855 Ensembl - ENSMUSG00000028459

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
	ENSGALG00000021353	Gallus gallus
CD72	ENSGALG00000005194	Gallus gallus
CD72AG	ENSGALG00000002383	Gallus gallus
CD72	ENSG00000137101	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR001304	C-type lectin-like
IPR016186	C-type lectin-like/link domain superfamily
IPR016187	C-type lectin fold

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
cellular_component	GO:0005887	integral component of plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0030246	carbohydrate binding	IEA

Pathways (from Reactome)

Pathway description

Other semaphorin interactions

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000523	cortical glomerulopathies	"any disease of the capillary plexus in the kidney cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]	Show Allelic Composition: Cd72^c/Cd72^c,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp
MP:0000702	enlarged lymph nodes	"lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd72^tm1Tsub/Cd72^tm1Tsub,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp Allelic Composition: Cd72^c/Cd72^c,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp
MP:0001805	decreased IgG	"less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd72^b/Cd72^b,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp
MP:0001844	autoimmune response	"condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cd72^tm1Tsub/Cd72^tm1Tsub,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp Allelic Composition: Cd72^c/Cd72^c,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp Allelic Composition: Cd72^b/Cd72^b,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp
MP:0001860	liver inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Cd72^tm1Tsub/Cd72^tm1Tsub,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp Allelic Composition: Cd72^c/Cd72^c,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp
MP:0001861	lung inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^tm1Sor,Pten^tm1Mro/Pten^tm1Mro,Rb1^tm2Brn/Rb1^tm2Brn,Trp53^tm1Brn/Trp53^tm1Brn Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N Allelic Composition: Cd72^tm1Tsub/Cd72^tm1Tsub,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp Allelic Composition: Cd72^c/Cd72^c,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp
MP:0002144	abnormal B lymphocyte development	"atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ar^Tfm/Y,Insl3^tm1Imad/Insl3^tm1Imad Genetic Background: involves: 129/Sv * CD-1 * STOCK Eda^Ta
MP:0002458	abnormal B cell number	"deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd72^tm1Tsub/Cd72^tm1Tsub,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp Allelic Composition: Cd72^c/Cd72^c,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp Allelic Composition: Cd72^b/Cd72^b,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp
MP:0002459	abnormal B cell physiology	"abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ar^Tfm/Y,Insl3^tm1Imad/Insl3^tm1Imad Genetic Background: involves: 129/Sv * CD-1 * STOCK Eda^Ta Allelic Composition: Cd72^tm1Jrp/Cd72^tm1Jrp,Tg(BCL2)22Wehi/0 Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6JWehi * SJL/JWehi) or (involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JWehi * SJL/JWehi)
MP:0002493	increased IgG	"greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd72^c/Cd72^c,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp
MP:0002494	increased IgM	"greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ar^Tfm/Y,Insl3^tm1Imad/Insl3^tm1Imad Genetic Background: involves: 129/Sv * CD-1 * STOCK Eda^Ta
MP:0002743	glomerulonephritis	"glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^tm1Sor,Pten^tm1Mro/Pten^tm1Mro,Rb1^tm2Brn/Rb1^tm2Brn,Trp53^tm1Brn/Trp53^tm1Brn Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N Allelic Composition: Cd72^tm1Tsub/Cd72^tm1Tsub,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp
MP:0003132	increased number of pre-B cells	"greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ar^Tfm/Y,Insl3^tm1Imad/Insl3^tm1Imad Genetic Background: involves: 129/Sv * CD-1 * STOCK Eda^Ta
MP:0004762	increased anti-double stranded DNA antibody level	"increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd72^tm1Tsub/Cd72^tm1Tsub Genetic Background: involves: C57BL/6J Allelic Composition: Cd72^tm1Tsub/Cd72^tm1Tsub,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp Allelic Composition: Cd72^c/Cd72^c,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp
MP:0004771	increased anti-single stranded DNA antibody level	"increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd72^tm1Tsub/Cd72^tm1Tsub Genetic Background: involves: C57BL/6J Allelic Composition: Cd72^tm1Tsub/Cd72^tm1Tsub,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp Allelic Composition: Cd72^c/Cd72^c,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp
MP:0004795	decreased anti-nuclear antigen antibody level	"reduced level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd72^b/Cd72^b,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp
MP:0004798	decreased anti-double stranded DNA antibody level	"reduced level of antibodies to double stranded DNA present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd72^b/Cd72^b,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp
MP:0004801	increased susceptibility to systemic lupus erythematosus	"greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd72^c/Cd72^c,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp
MP:0004829	increased anti-chromatin antibody level	"increase in the level of antibodies that recognize chromatin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd72^tm1Tsub/Cd72^tm1Tsub Genetic Background: involves: C57BL/6J Allelic Composition: Cd72^tm1Tsub/Cd72^tm1Tsub,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp Allelic Composition: Cd72^c/Cd72^c,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp
MP:0004952	increased spleen weight	"greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd72^tm1Tsub/Cd72^tm1Tsub Genetic Background: involves: C57BL/6J Allelic Composition: Cd72^tm1Tsub/Cd72^tm1Tsub,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp Allelic Composition: Cd72^c/Cd72^c,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp
MP:0004953	decreased spleen weight	"reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd72^b/Cd72^b,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp
MP:0004977	increased B-1 B cell number	"greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ar^Tfm/Y,Insl3^tm1Imad/Insl3^tm1Imad Genetic Background: involves: 129/Sv * CD-1 * STOCK Eda^Ta
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ar^Tfm/Y,Insl3^tm1Imad/Insl3^tm1Imad Genetic Background: involves: 129/Sv * CD-1 * STOCK Eda^Ta
MP:0005154	increased B cell proliferation	"greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ar^Tfm/Y,Insl3^tm1Imad/Insl3^tm1Imad Genetic Background: involves: 129/Sv * CD-1 * STOCK Eda^Ta Allelic Composition: Cd72^tm1Tsub/Cd72^tm1Tsub Genetic Background: involves: C57BL/6J Allelic Composition: Cd72^c/Cd72^c Genetic Background: involves: C57BL/6 * MRL
MP:0005325	abnormal glomerulus	"anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd72^b/Cd72^b,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp
MP:0005351	decreased susceptibility to autoimmune disorders	"reduced likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd72^b/Cd72^b,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp
MP:0006315	abnormal kidney protein excretion	"anomaly in the amount of protein eliminated by the kidneys" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd72^b/Cd72^b,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp
MP:0006387	abnormal T cell number	"deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd72^tm1Tsub/Cd72^tm1Tsub,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp Allelic Composition: Cd72^c/Cd72^c,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp Allelic Composition: Cd72^b/Cd72^b,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp
MP:0008167	increased B-1a cell number	"greater number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]	Show Allelic Composition: Ar^Tfm/Y,Insl3^tm1Imad/Insl3^tm1Imad Genetic Background: involves: 129/Sv * CD-1 * STOCK Eda^Ta
MP:0008174	decreased follicular B cell number	"reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ar^Tfm/Y,Insl3^tm1Imad/Insl3^tm1Imad Genetic Background: involves: 129/Sv * CD-1 * STOCK Eda^Ta
MP:0008181	increased marginal zone B cell number	"greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]	Show Allelic Composition: Ar^Tfm/Y,Insl3^tm1Imad/Insl3^tm1Imad Genetic Background: involves: 129/Sv * CD-1 * STOCK Eda^Ta
MP:0008186	increased pro-B cell number	"greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ar^Tfm/Y,Insl3^tm1Imad/Insl3^tm1Imad Genetic Background: involves: 129/Sv * CD-1 * STOCK Eda^Ta
MP:0008207	decreased B-2 cell number	"reduced number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]	Show Allelic Composition: Ar^Tfm/Y,Insl3^tm1Imad/Insl3^tm1Imad Genetic Background: involves: 129/Sv * CD-1 * STOCK Eda^Ta
MP:0008211	decreased mature B cell number	"reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]	Show Allelic Composition: Ar^Tfm/Y,Insl3^tm1Imad/Insl3^tm1Imad Genetic Background: involves: 129/Sv * CD-1 * STOCK Eda^Ta Allelic Composition: Cd72^tm1Jrp/Cd72^tm1Jrp,Tg(BCL2)22Wehi/0 Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6JWehi * SJL/JWehi) or (involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JWehi * SJL/JWehi)
MP:0008214	increased immature B cell number	"greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ar^Tfm/Y,Insl3^tm1Imad/Insl3^tm1Imad Genetic Background: involves: 129/Sv * CD-1 * STOCK Eda^Ta Allelic Composition: Cd72^tm1Jrp/Cd72^tm1Jrp,Tg(BCL2)22Wehi/0 Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6JWehi * SJL/JWehi) or (involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JWehi * SJL/JWehi)
MP:0008217	abnormal B cell activation	"any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ar^Tfm/Y,Insl3^tm1Imad/Insl3^tm1Imad Genetic Background: involves: 129/Sv * CD-1 * STOCK Eda^Ta
MP:0020518	renal glomerular protein deposits	"any anomalous accumulation of protein in the renal glomerulus" [HP:0030949]	Show Allelic Composition: Cd72^b/Cd72^b,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp
MP:0020519	renal glomerular immunoglobulin deposits	"any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]	Show Allelic Composition: Cd72^tm1Tsub/Cd72^tm1Tsub Genetic Background: involves: C57BL/6J Allelic Composition: Cd72^tm1Tsub/Cd72^tm1Tsub,Fas^lpr/Fas^lpr Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000021451	O09126 / Sema4d / Semaphorin-4D / Q92854*	/ reaction / complex

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr