ENSMUSG00000028476


Mus musculus

Features
Gene ID: ENSMUSG00000028476
  
Biological name :Reck
  
Synonyms : Q9Z0J1 / Reck / reversion-inducing-cysteine-rich protein with kazal motifs
  
Possible biological names infered from orthology : O95980
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: B1
Gene start: 43875530
Gene end: 43944806
  
Corresponding Affymetrix probe sets: 10504424 (MoGene1.0st)   1450784_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030198
NCBI entrez gene - 53614     See in Manteia.
MGI - MGI:1855698
RefSeq - NM_016678
RefSeq - XM_006538086
RefSeq Peptide - NP_057887
swissprot - Q9Z0J1
Ensembl - ENSMUSG00000028476
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 reckENSDARG00000090039Danio rerio
 RECKENSGALG00000036829Gallus gallus
 RECKENSG00000122707Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002350  Kazal domain
 IPR036058  Kazal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001955 blood vessel maturation IMP
 biological_processGO:0007566 embryo implantation IDA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0035115 embryonic forelimb morphogenesis IMP
 biological_processGO:1904684 negative regulation of metalloendopeptidase activity IMP
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 molecular_functionGO:0004866 endopeptidase inhibitor activity IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Post-translational modification: synthesis of GPI-anchored proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Disp1tm1Pab/Disp1tm1Pab,Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Recktm2.2Noda/Recktm3.1(cre/ERT2)Noda
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eomestm1.1Bflu/Eomestm1.1Bflu,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

Allelic Composition: Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: Disp1tm1Pab/Disp1tm1Pab,Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001676 abnormal apical ectodermal ridge "malformation of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Recktm2.2Noda/Recktm3.1(cre/ERT2)Noda
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Disp1tm1Pab/Disp1tm1Pab,Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Eomestm1.1Bflu/Eomestm1.1Bflu,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

Allelic Composition: Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Recktm2.2Noda/Recktm3.1(cre/ERT2)Noda
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Recktm2.2Noda/Recktm3.1(cre/ERT2)Noda
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Eomestm1.1Bflu/Eomestm1.1Bflu,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Disp1tm1Pab/Disp1tm1Pab,Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eomestm1.1Bflu/Eomestm1.1Bflu,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0004273 abnormal basal lamina morphology "anomaly in the structure of the sheet of extracellular matrix characteristically situated under epithelial cells, around muscles, nerves, capillaries, and fat cells, and situated between these elements and the underlying or surrounding connective tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Disp1tm1Pab/Disp1tm1Pab,Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004360 absent ulna "missing the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Recktm2.2Noda/Recktm3.1(cre/ERT2)Noda
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0004938 dilated vasculature "stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eomestm1.1Bflu/Eomestm1.1Bflu,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

Allelic Composition: Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eomestm1.1Bflu/Eomestm1.1Bflu,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0005650 abnormal limb bud morphology "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Recktm2.2Noda/Recktm3.1(cre/ERT2)Noda
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Disp1tm1Pab/Disp1tm1Pab,Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Recktm2.2Noda/Recktm3.1(cre/ERT2)Noda
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0009577 abnormal developmental vascular remodeling "any anomaly in the process by which existing vessels are reorganized during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eomestm1.1Bflu/Eomestm1.1Bflu,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0009820 abnormal liver vasculature morphology "any structural anomaly of the blood vessel network of the bile-secreting exocrine gland" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eomestm1.1Bflu/Eomestm1.1Bflu,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Disp1tm1Pab/Disp1tm1Pab,Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Recktm1Ito/Recktm1Ito
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Eomestm1.1Bflu/Eomestm1.1Bflu,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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