ENSMUSG00000028576


Mus musculus

Features
Gene ID: ENSMUSG00000028576
  
Biological name :Ift74
  
Synonyms : Ift74 / Intraflagellar transport / Q8BKE9
  
Possible biological names infered from orthology : intraflagellar transport 74 / Q96LB3
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C5
Gene start: 94614491
Gene end: 94693229
  
Corresponding Affymetrix probe sets: 10505931 (MoGene1.0st)   1418942_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030311
Ensembl peptide - ENSMUSP00000102721
NCBI entrez gene - 67694     See in Manteia.
MGI - MGI:1914944
RefSeq - XM_011240598
RefSeq - NM_001290568
RefSeq - NM_026319
RefSeq - XM_006503327
RefSeq - XM_006503328
RefSeq - XM_006503329
RefSeq - XM_011240597
RefSeq - XM_006503324
RefSeq - XM_006503326
RefSeq Peptide - NP_001277497
RefSeq Peptide - NP_080595
swissprot - Q8BKE9
swissprot - B1AWG1
Ensembl - ENSMUSG00000028576
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ift74ENSDARG00000023495Danio rerio
 IFT74ENSGALG00000001801Gallus gallus
 IFT74ENSG00000096872Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR029602  Intraflagellar transport protein 74


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003334 keratinocyte development IMP
 biological_processGO:0007219 Notch signaling pathway IMP
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008544 epidermis development IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0033630 positive regulation of cell adhesion mediated by integrin IMP
 biological_processGO:0035735 intraciliary transport involved in cilium assembly IEA
 biological_processGO:0042073 intraciliary transport IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IMP
 biological_processGO:0060271 cilium assembly IEA
 biological_processGO:1905515 non-motile cilium assembly IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005929 cilium TAS
 cellular_componentGO:0030992 intraciliary transport particle B IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0048487 beta-tubulin binding IEA


Pathways (from Reactome)
Pathway description
Intraflagellar transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
Show

Allelic Composition: Tgm3we/Tgm3we-3J
Genetic Background: involves 129P3/J * C57BL/10 * NZB/BlNJ * UW

 MP:0002132 abnormal respiratory system morphology "anomalous structure of pulmonary tissues " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tgm3we/Tgm3we-3J
Genetic Background: involves 129P3/J * C57BL/10 * NZB/BlNJ * UW

 MP:0004133 heterotaxia "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Tgm3we/Tgm3we-3J
Genetic Background: involves 129P3/J * C57BL/10 * NZB/BlNJ * UW

 MP:0006063 abnormal inferior vena cava morphology "structural malformation in the principal vein draining blood from the lower portion of the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: Tgm3we/Tgm3we-3J
Genetic Background: involves 129P3/J * C57BL/10 * NZB/BlNJ * UW

 MP:0010406 absent atrial septum "absence of the thin membranous structure between the two heart atria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgm3we/Tgm3we-3J
Genetic Background: involves 129P3/J * C57BL/10 * NZB/BlNJ * UW

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
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Allelic Composition: Tgm3we/Tgm3we-3J
Genetic Background: involves 129P3/J * C57BL/10 * NZB/BlNJ * UW

 MP:0010975 abnormal lung lobe morphology "any structural anomaly of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tgm3we/Tgm3we-3J
Genetic Background: involves 129P3/J * C57BL/10 * NZB/BlNJ * UW

 MP:0011667 double outlet right ventricle with atrioventricular septal defect "a form of DORV in which there is also a complete atrioventricular canal" [MGI:csmith]
Show

Allelic Composition: Tgm3we/Tgm3we-3J
Genetic Background: involves 129P3/J * C57BL/10 * NZB/BlNJ * UW

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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