ENSMUSG00000028581


Mus musculus

Features
Gene ID: ENSMUSG00000028581
  
Biological name :Laptm5
  
Synonyms : Laptm5 / lysosomal-associated protein transmembrane 5 / Q61168
  
Possible biological names infered from orthology : lysosomal protein transmembrane 5 / Q13571
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.2
Gene start: 130913125
Gene end: 130936141
  
Corresponding Affymetrix probe sets: 10508663 (MoGene1.0st)   1417721_s_at (Mouse Genome 430 2.0 Array)   1426025_s_at (Mouse Genome 430 2.0 Array)   1436905_x_at (Mouse Genome 430 2.0 Array)   1447742_at (Mouse Genome 430 2.0 Array)   1459841_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030316
Ensembl peptide - ENSMUSP00000118415
Ensembl peptide - ENSMUSP00000121133
Ensembl peptide - ENSMUSP00000123382
NCBI entrez gene - 16792     See in Manteia.
MGI - MGI:108046
RefSeq - XM_017320001
RefSeq - NM_010686
RefSeq Peptide - NP_034816
swissprot - F6WX18
swissprot - B1ASF7
swissprot - Q544S4
swissprot - Q61168
swissprot - F8WH95
Ensembl - ENSMUSG00000028581
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 laptm5ENSDARG00000101785Danio rerio
 LAPTM5ENSGALG00000038636Gallus gallus
 LAPTM5ENSG00000162511Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004687  Lysosomal-associated transmembrane protein 4/5
 IPR018396  Lysosomal-associated transmembrane protein, 4A/5
 IPR018397  Lysosomal-associated transmembrane protein 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Irs1tm2Tka/Irs1tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0002534 type IV hypersensitivity reaction "an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Irs1tm2Tka/Irs1tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs1tm2Tka/Irs1tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kptntm1a(EUCOMM)Wtsi/Kptntm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Kptntm1a(EUCOMM)Wtsi/Wtsi

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Irs1tm2Tka/Irs1tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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