ENSMUSG00000028683


Mus musculus

Features
Gene ID: ENSMUSG00000028683
  
Biological name :Eif2b3
  
Synonyms : Eif2b3 / eukaryotic translation initiation factor 2B subunit gamma
  
Possible biological names infered from orthology : Q9NR50
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D1
Gene start: 117019402
Gene end: 117087306
  
Corresponding Affymetrix probe sets: 10507418 (MoGene1.0st)   1434524_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102056
Ensembl peptide - ENSMUSP00000070334
Ensembl peptide - ENSMUSP00000102055
NCBI entrez gene - 108067     See in Manteia.
MGI - MGI:1313286
RefSeq - XM_006502650
RefSeq - NM_001111277
RefSeq - NM_175135
RefSeq - XM_006502649
RefSeq Peptide - NP_001104747
RefSeq Peptide - NP_780344
swissprot - B1AUN3
swissprot - Q3UKV0
swissprot - B1AUN2
Ensembl - ENSMUSG00000028683
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif2b3ENSDARG00000018106Danio rerio
 EIF2B3ENSGALG00000010140Gallus gallus
 EIF2B3ENSG00000070785Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005835  Nucleotidyl transferase domain
 IPR029044  Nucleotide-diphospho-sugar transferases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006413 translational initiation ISO
 biological_processGO:0009058 biosynthetic process IEA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0014003 oligodendrocyte development ISS
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0050852 T cell receptor signaling pathway ISS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005851 eukaryotic translation initiation factor 2B complex ISS
 molecular_functionGO:0003743 translation initiation factor activity ISO
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity ISO
 molecular_functionGO:0008135 translation factor activity, RNA binding ISS
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Recycling of eIF2:GDP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ehmt1tm1b(EUCOMM)Hmgu/Ehmt1+
Genetic Background: C57BL/6N-Ehmt1tm1b(EUCOMM)Hmgu/Nju

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Ehmt1tm1b(EUCOMM)Hmgu/Ehmt1+
Genetic Background: C57BL/6N-Ehmt1tm1b(EUCOMM)Hmgu/Nju

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Ehmt1tm1b(EUCOMM)Hmgu/Ehmt1+
Genetic Background: C57BL/6N-Ehmt1tm1b(EUCOMM)Hmgu/Nju

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Ehmt1tm1b(EUCOMM)Hmgu/Ehmt1+
Genetic Background: C57BL/6N-Ehmt1tm1b(EUCOMM)Hmgu/Nju

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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