ENSMUSG00000028687


Mus musculus

Features
Gene ID: ENSMUSG00000028687
  
Biological name :Mutyh
  
Synonyms : Adenine DNA glycosylase / Mutyh / Q99P21
  
Possible biological names infered from orthology : mutY DNA glycosylase / Q9UIF7
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D1
Gene start: 116807723
Gene end: 116819440
  
Corresponding Affymetrix probe sets: 10507362 (MoGene1.0st)   1422816_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122777
Ensembl peptide - ENSMUSP00000099760
Ensembl peptide - ENSMUSP00000122549
NCBI entrez gene - 70603     See in Manteia.
MGI - MGI:1917853
RefSeq - XM_011240613
RefSeq - NM_001159581
RefSeq - NM_001316747
RefSeq - NM_133250
RefSeq - XM_006503392
RefSeq - XM_006503394
RefSeq Peptide - NP_001303676
RefSeq Peptide - NP_573513
RefSeq Peptide - NP_001153053
swissprot - E9Q9J3
swissprot - Q99P21
swissprot - A8Y5N1
Ensembl - ENSMUSG00000028687
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CT025742.1ENSDARG00000074889Danio rerio
 MUTYHENSGALG00000010226Gallus gallus
 MUTYHENSG00000132781Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000086  NUDIX hydrolase domain
 IPR000445  Helix-hairpin-helix motif
 IPR003265  HhH-GPD domain
 IPR003651  Endonuclease III-like, iron-sulphur cluster loop motif
 IPR004035  Endonuclease III, iron-sulphur binding site
 IPR004036  Endonuclease III-like, conserved site-2
 IPR011257  DNA glycosylase
 IPR015797  NUDIX hydrolase-like domain superfamily
 IPR023170  Helix-turn-helix, base-excision DNA repair, C-terminal
 IPR029119  MutY, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair TAS
 biological_processGO:0006284 base-excision repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005739 mitochondrion IDA
 molecular_functionGO:0000701 purine-specific mismatch base pair DNA N-glycosylase activity IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0019104 DNA N-glycosylase activity TAS
 molecular_functionGO:0032407 MutSalpha complex binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
Cleavage of the damaged purine
Displacement of DNA glycosylase by APEX1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Msh2tm1Mak/Msh2tm1Mak,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Msh2tm1Mak/Msh2+,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Mutyhtm1Yun/Mutyhtm1Yun,Nudt1tm1Tts/Nudt1tm1Tts,Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: B6JJcl.129-Mutyhtm1Yun Nudt1tm1Tts Ogg1tm1Skmi

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Msh2tm1Mak/Msh2+,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
Show

Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Msh2tm1Mak/Msh2tm1Mak,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Msh2tm1Mak/Msh2+,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Msh2tm1Mak/Msh2tm1Mak,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Msh2tm1Mak/Msh2+,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

 MP:0002947 hemangioma "proliferation of blood vessels leading to a mass that resembles a neoplasm" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87544]
Show

Allelic Composition: Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Msh2tm1Mak/Msh2+,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

 MP:0008236 decreased susceptibility to neuronal excitotoxicity "less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mutyhtm1Yun/Mutyhtm1Yun,Nudt1tm1Tts/Nudt1tm1Tts,Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: B6JJcl.129-Mutyhtm1Yun Nudt1tm1Tts Ogg1tm1Skmi

Allelic Composition: Mutyhtm1Yun/Mutyhtm1Yun
Genetic Background: involves: 129 * C57BL/6JJcl

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Msh2tm1Mak/Msh2tm1Mak,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Msh2tm1Mak/Msh2+,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000035960 Apex1 / P28352 / DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) lyase, mitochondrial / P27695* / apurinic/apyrimidinic endodeoxyribonuclease 1*  / reaction






 

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