ENSMUSG00000028917


Mus musculus

Features
Gene ID: ENSMUSG00000028917
  
Biological name :Plekhm2
  
Synonyms : Mus musculus pleckstrin homology domain containing, family M (with RUN domain) member 2 (Plekhm2), transcript variant 2, mRNA. / Plekhm2
  
Possible biological names infered from orthology : pleckstrin homology and RUN domain containing M2 / Q8IWE5
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E1
Gene start: 141625734
Gene end: 141664899
  
Corresponding Affymetrix probe sets: 10517996 (MoGene1.0st)   1437740_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030751
Ensembl peptide - ENSMUSP00000081221
NCBI entrez gene - 69582     See in Manteia.
MGI - MGI:1916832
RefSeq - NM_001033150
RefSeq - NM_001347237
RefSeq - XM_006539156
RefSeq Peptide - NP_001028322
RefSeq Peptide - NP_001334166
swissprot - A2ADE0
swissprot - Z4YJW6
Ensembl - ENSMUSG00000028917
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plekhm2ENSDARG00000078850Danio rerio
 PLEKHM2ENSGALG00000003439Gallus gallus
 Q8IWE5ENSG00000116786Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR004012  RUN domain
 IPR011993  PH-like domain superfamily
 IPR037213  RUN domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007030 Golgi organization IEA
 biological_processGO:0032418 lysosome localization IEA
 biological_processGO:0032880 regulation of protein localization IEA
 biological_processGO:1903527 positive regulation of membrane tubulation IEA
 cellular_componentGO:0010008 endosome membrane IEA
 molecular_functionGO:0019894 kinesin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pitpnm1tm1a(EUCOMM)Wtsi/Pitpnm1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pitpnm1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pitpnm1tm1a(EUCOMM)Wtsi/Pitpnm1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pitpnm1tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Plekhm2tm1a(EUCOMM)Wtsi/Plekhm2tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Pitpnm1tm1a(EUCOMM)Wtsi/Pitpnm1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pitpnm1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
Genetic Background: B6.129X1-Nfe2l2tm1Ywk/J

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pitpnm1tm1a(EUCOMM)Wtsi/Pitpnm1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pitpnm1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Plekhm2tm1a(EUCOMM)Wtsi/Plekhm2tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plekhm2tm1a(EUCOMM)Wtsi/Plekhm2tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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