ENSMUSG00000028959


Mus musculus

Features
Gene ID: ENSMUSG00000028959
  
Biological name :Fastk
  
Synonyms : Fas activated serine/threonine kinase / Fastk
  
Possible biological names infered from orthology : Q14296
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: A3
Gene start: 24438440
Gene end: 24445287
  
Corresponding Affymetrix probe sets: 10528598 (MoGene1.0st)   1460635_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030800
Ensembl peptide - ENSMUSP00000123447
Ensembl peptide - ENSMUSP00000110695
Ensembl peptide - ENSMUSP00000110693
NCBI entrez gene - 66587     See in Manteia.
MGI - MGI:1913837
RefSeq - XM_017321067
RefSeq - NM_023229
RefSeq - XM_017321066
RefSeq Peptide - NP_075718
swissprot - E9QA06
swissprot - Q8C725
swissprot - D3Z4M5
swissprot - D6RCW0
Ensembl - ENSMUSG00000028959
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fastkENSDARG00000077075Danio rerio
 FASTKENSGALG00000033058Gallus gallus
 FASTKENSG00000164896Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BSN9 / Fastkd3 / FAST kinase domain-containing protein 3, mitochondrial / Q14CZ7* / FAST kinase domains 3*ENSMUSG0000002153223
Tbrg4 / Q91YM4 / Protein TBRG4 / Q969Z0* / transforming growth factor beta regulator 4*ENSMUSG0000000038420
Q6DI86 / Fastkd1 / FAST kinase domain-containing protein 1, mitochondrial / Q53R41* / FAST kinase domains 1*ENSMUSG0000002708618


Protein motifs (from Interpro)
Interpro ID Name
 IPR010622  FAST kinase leucine-rich
 IPR013579  FAST kinase-like protein, subdomain 2
 IPR013584  RAP domain
 IPR015715  Fas activated serine/threonine kinase FAST


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0043484 regulation of RNA splicing IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hsp90b1tm1.2Alee/Hsp90b1tm1.2Alee
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hsp90b1tm1.2Alee/Hsp90b1tm1.2Alee
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Hsp90b1tm1.2Alee/Hsp90b1tm1.2Alee
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0008691 decreased interleukin-23 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells" [MESH:D12.644.276.374.465.759]
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Allelic Composition: Hsp90b1tm1.2Alee/Hsp90b1tm1.2Alee
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Hsp90b1tm1.2Alee/Hsp90b1tm1.2Alee
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Hsp90b1tm1.2Alee/Hsp90b1tm1.2Alee
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hsp90b1tm1.2Alee/Hsp90b1tm1.2Alee
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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