ENSMUSG00000028971


Mus musculus

Features
Gene ID: ENSMUSG00000028971
  
Biological name :Cort
  
Synonyms : Cort / Cortistatin Cortistatin-14 / P56469
  
Possible biological names infered from orthology : cortistatin / O00230
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 149125034
Gene end: 149126763
  
Corresponding Affymetrix probe sets: 10518557 (MoGene1.0st)   1449820_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030815
NCBI entrez gene - 12854     See in Manteia.
MGI - MGI:109538
RefSeq - NM_007745
RefSeq Peptide - NP_031771
swissprot - P56469
Ensembl - ENSMUSG00000028971
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CORTENSG00000241563Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004250  Somatostatin
 IPR018142  Somatostatin/Cortistatin, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005184 neuropeptide hormone activity IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Atp4am1Btlr/Atp4am1Btlr
Genetic Background: involves: C57BL/6J

 MP:0001748 increased circulating adrenocorticotropin level "elevated concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Atp4am1Btlr/Atp4am1Btlr
Genetic Background: involves: C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sptbn4qv-J/Sptbn4qv-J
Genetic Background: C3FeB6 A/Aw-J-Sptbn4qv-J/J

 MP:0005121 decreased circulating prolactin level "less than expected blood concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atp4am1Btlr/Atp4am1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005123 increased circulating growth hormone level "greater than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atp4am1Btlr/Atp4am1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005129 increased adrenocorticotropin level "increased concentration of adrenocorticotropic hormone " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atp4am1Btlr/Atp4am1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005138 decreased prolactin level "less than expected concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atp4am1Btlr/Atp4am1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp4am1Btlr/Atp4am1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Atp4am1Btlr/Atp4am1Btlr
Genetic Background: involves: C57BL/6J

 MP:0011067 abnormal somatostatin level "anomaly of the blood or tissue concentration of a tetradecapeptide capable of inhibiting the release of somatotrophin by the anterior lobe of the pituitary gland and the release of insulin and gastrin from digestive system tissues" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Atp4am1Btlr/Atp4am1Btlr
Genetic Background: involves: C57BL/6J

 MP:0011612 increased circulating ghrelin level "greater than the normal blood concentration of the peptide hormone produced mainly by P/D1 cells lining the fundus of the stomach and epsilon cells of the pancreas that normally stimulates hunger and serves as a potent stimulator of growth hormone from the anterior pituitary gland" [MGI:anna]
Show

Allelic Composition: Atp4am1Btlr/Atp4am1Btlr
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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