ENSMUSG00000029005


Mus musculus

Features
Gene ID: ENSMUSG00000029005
  
Biological name :Draxin
  
Synonyms : Draxin / Q6PAL1
  
Possible biological names infered from orthology : dorsal inhibitory axon guidance protein / Q8NBI3
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 148098437
Gene end: 148130698
  
Corresponding Affymetrix probe sets: 10518464 (MoGene1.0st)   1432152_at (Mouse Genome 430 2.0 Array)   1456158_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030862
NCBI entrez gene - 70433     See in Manteia.
MGI - MGI:1917683
RefSeq - NM_027426
RefSeq - XM_006539170
RefSeq Peptide - NP_081702
swissprot - Q6PAL1
Ensembl - ENSMUSG00000029005
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 draxinENSDARG00000058256Danio rerio
 si:dkey-1c11.1ENSDARG00000087681Danio rerio
 B6ZI38ENSGALG00000004631Gallus gallus
 DRAXINENSG00000162490Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR029094  Draxin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0021516 dorsal spinal cord development IMP
 biological_processGO:0021528 commissural neuron differentiation in spinal cord IMP
 biological_processGO:0030517 negative regulation of axon extension IDA
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IDA
 cellular_componentGO:0005576 extracellular region IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Olig3tm1Tre/Olig3tm2(cre/ERT2)Cbm
Genetic Background: Not Specified

Allelic Composition: Draxintm1Htnk/Draxin+
Genetic Background: involves: C57BL/6NCrj * CBA/JNCrj

 MP:0002196 acallosal "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Olig3tm1Tre/Olig3tm2(cre/ERT2)Cbm
Genetic Background: Not Specified

Allelic Composition: Draxintm1Htnk/Draxin+
Genetic Background: involves: C57BL/6NCrj * CBA/JNCrj

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fxnem2Lutzy/Fxnem2.1Lutzy,Tg(Ckmm-cre)5Khn/?
Genetic Background: B6.Cg-Fxnem2Lutzy Fxnem2.1Lutzy Tg(Ckmm-cre)5Khn/J

 MP:0004100 abnormal spinal cord interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Olig3tm1Tre/Olig3tm2(cre/ERT2)Cbm
Genetic Background: Not Specified

 MP:0008222 decreased hippocampal commissure size "reduced size of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Olig3tm1Tre/Olig3tm2(cre/ERT2)Cbm
Genetic Background: Not Specified

Allelic Composition: Draxintm1Htnk/Draxin+
Genetic Background: involves: C57BL/6NCrj * CBA/JNCrj

 MP:0008223 absent hippocampal commissure "absence of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Olig3tm1Tre/Olig3tm2(cre/ERT2)Cbm
Genetic Background: Not Specified

Allelic Composition: Draxintm1Htnk/Draxin+
Genetic Background: involves: C57BL/6NCrj * CBA/JNCrj

 MP:0008226 decreased anterior commissure size "reduced size of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Olig3tm1Tre/Olig3tm2(cre/ERT2)Cbm
Genetic Background: Not Specified

Allelic Composition: Draxintm1Htnk/Draxin+
Genetic Background: involves: C57BL/6NCrj * CBA/JNCrj

 MP:0008227 absent anterior commissure "absence of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Olig3tm1Tre/Olig3tm2(cre/ERT2)Cbm
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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