ENSMUSG00000029103


Mus musculus

Features
Gene ID: ENSMUSG00000029103
  
Biological name :Lrpap1
  
Synonyms : low density lipoprotein receptor-related protein associated protein 1 / Lrpap1 / P55302
  
Possible biological names infered from orthology : LDL receptor related protein associated protein 1 / P30533
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B2
Gene start: 35091501
Gene end: 35105766
  
Corresponding Affymetrix probe sets: 10529445 (MoGene1.0st)   1426696_at (Mouse Genome 430 2.0 Array)   1426697_a_at (Mouse Genome 430 2.0 Array)   1436609_a_at (Mouse Genome 430 2.0 Array)   1452148_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030986
Ensembl peptide - ENSMUSP00000120233
NCBI entrez gene - 16976     See in Manteia.
MGI - MGI:96829
RefSeq - NM_013587
RefSeq Peptide - NP_038615
swissprot - F6WMD1
swissprot - P55302
swissprot - Q52KI7
Ensembl - ENSMUSG00000029103
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrpap1ENSDARG00000033604Danio rerio
 LRPAP1ENSGALG00000015612Gallus gallus
 LRPAP1ENSG00000163956Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009066  Alpha-2-macroglobulin receptor-associated protein, domain 1
 IPR010483  Alpha-2-macroglobulin RAP, C-terminal
 IPR036744  RAP domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002091 negative regulation of receptor internalization IEA
 biological_processGO:0010916 negative regulation of very-low-density lipoprotein particle clearance IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0045056 transcytosis IEA
 biological_processGO:0048259 regulation of receptor-mediated endocytosis IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:1900116 extracellular negative regulation of signal transduction IEA
 biological_processGO:1900222 negative regulation of amyloid-beta clearance IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005796 Golgi lumen IEA
 cellular_componentGO:0005801 cis-Golgi network IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0031904 endosome lumen IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0048237 rough endoplasmic reticulum lumen ISO
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0035473 lipase binding IEA
 molecular_functionGO:0048019 receptor antagonist activity IEA
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding IEA
 molecular_functionGO:0070326 very-low-density lipoprotein particle receptor binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000681 abnormal thyroid gland morphology "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Chrm2tm1Minm/Chrm2tm1Minm,Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Lrpap1tm1Her/Lrpap1tm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: ApcMin/Apc+,Ptgs1tm1Unc/Ptgs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrp1btm1Her/Lrp1btm1Her
Genetic Background: 129S/SvEv-Lrp1btm1Her

 MP:0002876 abnormal thyroid physiology "anomalous function of this endocrine gland that normally produces hormones that regulate the metabolic rate of the body " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0003329 amyloid beta deposits 
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rxratm1Ipc/Rxratm4Ipc,Rxrbtm1Mma/Rxrbtm1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Lrpap1tm1Her/Lrpap1tm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Chrm2tm1Minm/Chrm2tm1Minm,Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chrm2tm1Minm/Chrm2tm1Minm,Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: ApcMin/Apc+,Ptgs1tm1Unc/Ptgs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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