ENSMUSG00000029288


Mus musculus

Features
Gene ID: ENSMUSG00000029288
  
Biological name :Ambn
  
Synonyms : Ambn / Ameloblastin / O55189
  
Possible biological names infered from orthology : Q9NP70
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: E1
Gene start: 88455991
Gene end: 88468531
  
Corresponding Affymetrix probe sets: 10522946 (MoGene1.0st)   1449417_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031226
Ensembl peptide - ENSMUSP00000142944
NCBI entrez gene - 11698     See in Manteia.
MGI - MGI:104655
RefSeq - NM_009664
RefSeq - NM_001303431
RefSeq Peptide - NP_001290360
RefSeq Peptide - NP_033794
swissprot - O55189
swissprot - Q5M8P3
Ensembl - ENSMUSG00000029288
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AMBNENSG00000178522Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007798  Ameloblastin precursor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IMP
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0031214 biomineral tissue development IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0008083 growth factor activity IMP
 molecular_functionGO:0030021 extracellular matrix structural constituent conferring compression resistance TAS
 molecular_functionGO:0030345 structural constituent of tooth enamel IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000454 abnormal jaw morphology "malformation of the bony framework of the mouth where the teeth are held" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Plattm1Mlg/Plattm1Mlg
Genetic Background: B6.Cg-Plattm1Mlg

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Plattm1Mlg/Plattm1Mlg
Genetic Background: B6.Cg-Plattm1Mlg

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plattm1Mlg/Plattm1Mlg
Genetic Background: B6.Cg-Plattm1Mlg

 MP:0002650 abnormal ameloblast morphology "malformation of the epithelial cells of the inner layer of the enamel organ of the developing tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plattm1Mlg/Plattm1Mlg
Genetic Background: B6.Cg-Plattm1Mlg

 MP:0003404 absent enamel "absence of the hard outer coating of the exposed portion of the tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:92017]
Show

Allelic Composition: Plattm1Mlg/Plattm1Mlg
Genetic Background: B6.Cg-Plattm1Mlg

 MP:0003932 abnormal molar crown morphology "defects in the upper part of the molar, which is normally covered with enamel " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Plattm1Mlg/Plattm1Mlg
Genetic Background: B6.Cg-Plattm1Mlg

 MP:0005358 abnormal incisor morphology "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
Show

Allelic Composition: Plattm1Mlg/Plattm1Mlg
Genetic Background: B6.Cg-Plattm1Mlg

 MP:0010096 abnormal incisor color "anomaly in the color and shading of the incisor, which normally presents in shades of white" [PMID:12407097]
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Allelic Composition: Plattm1Mlg/Plattm1Mlg
Genetic Background: B6.Cg-Plattm1Mlg

 MP:0030459 abnormal tooth attrition "change in the physiologic wearing away of tooth structure as a result of abnormal tooth-to-tooth contact, as in mastication, occurring only on the occlusal, incisal, and proximal surfaces" [PMID:22240686, RDO:0007259]
Show

Allelic Composition: Plattm1Mlg/Plattm1Mlg
Genetic Background: B6.Cg-Plattm1Mlg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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