Manteia - Molecule gene

ENSMUSG00000029502

Mus musculus

Features

Gene ID:	ENSMUSG00000029502

Biological name :	Golga3

Synonyms :	Golga3 / golgi autoantigen, golgin subfamily a, 3

Possible biological names infered from orthology :	golgin A3 / Q08378

Species:	Mus musculus

Chr. number:	5
Strand:	1
Band:	F
Gene start:	110176701
Gene end:	110226470

Corresponding Affymetrix probe sets:	10524124 (MoGene1.0st) 1419159_at (Mouse Genome 430 2.0 Array) 1419160_at (Mouse Genome 430 2.0 Array) 1449616_s_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000031477 Ensembl peptide - ENSMUSP00000115367 Ensembl peptide - ENSMUSP00000108131 NCBI entrez gene - 269682 See in Manteia. MGI - MGI:96958 RefSeq - XM_006534960 RefSeq - XM_006534962 RefSeq - XM_006534961 RefSeq - NM_001347389 RefSeq - NM_008146 RefSeq Peptide - NP_001334318 RefSeq Peptide - NP_032172 swissprot - E9QP99 swissprot - A0A0R4J1H6 swissprot - D3Z0Q8 Ensembl - ENSMUSG00000029502

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
golga3	ENSDARG00000062511	Danio rerio
GOLGA3	ENSGALG00000002158	Gallus gallus
GOLGA3	ENSG00000090615	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR033288	Golgin subfamily A member 3

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007283	spermatogenesis	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0005730	nucleolus	IEA
cellular_component	GO:0005794	Golgi apparatus	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0017119	Golgi transport complex	IEA
cellular_component	GO:0090498	extrinsic component of Golgi membrane	IEA
molecular_function	GO:0045296	cadherin binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000242	impaired fertilization	"defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lhx4^tm1Ssp/Lhx4^tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1
MP:0001146	abnormal testis morphology	"anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lhx4^tm1Ssp/Lhx4^tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1 Allelic Composition: Golga3^repro27/Golga3^repro27 Genetic Background: C3Fe.B6-Golga3^repro27
MP:0001147	small testis	"reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]	Show Allelic Composition: Prkar1a^tm2Gsm/Prkar1a^tm2Gsm,Tlx2^{tm1.1(cre)Rpk}/Tlx2⁺ Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/6N * DBA/2
MP:0001156	abnormal spermatogenesis	"incomplete maturation or aberrant formation of the male gametes" [J:58959]	Show Allelic Composition: Lhx4^tm1Ssp/Lhx4^tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Lhx4^tm1Ssp/Lhx4^tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1 Allelic Composition: Golga3^{Tg(06MGMT)T604Kccri}/Golga3^{Tg(06MGMT)T604Kccri} Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H
MP:0001932	abnormal spermiogenesis	"failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lhx4^tm1Ssp/Lhx4^tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1
MP:0002675	asthenozoospermia	"loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Lhx4^tm1Ssp/Lhx4^tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1
MP:0002686	globozoospermia	"malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]	Show Allelic Composition: Lhx4^tm1Ssp/Lhx4^tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1
MP:0002687	oligozoospermia	"reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]	Show Allelic Composition: Lhx4^tm1Ssp/Lhx4^tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1 Allelic Composition: Golga3^{Tg(06MGMT)T604Kccri}/Golga3^{Tg(06MGMT)T604Kccri} Genetic Background: involves: C3H * C57BL/6
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H
MP:0002968	increased circulating alkaline phosphatase level	"elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H
MP:0004852	decreased testis weight	"reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lhx4^tm1Ssp/Lhx4^tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1
MP:0004901	decreased male germ cell number	"reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lhx4^tm1Ssp/Lhx4^tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1
MP:0005159	azoospermia	"absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lhx4^tm1Ssp/Lhx4^tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1
MP:0005293	impaired glucose tolerance	"less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H
MP:0005578	teratozoospermia	"presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]	Show Allelic Composition: Lhx4^tm1Ssp/Lhx4^tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1
MP:0008280	male germ cell apoptosis	"presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lhx4^tm1Ssp/Lhx4^tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1
MP:0008545	absent sperm flagella	"mature spermatozoa lack a flagella" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lhx4^tm1Ssp/Lhx4^tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1
MP:0008893	detached sperm flagellum	"fragmentation of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility from the sperm head" [MESH:A05.360.490.890.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lhx4^tm1Ssp/Lhx4^tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1
MP:0009230	abnormal sperm head morphology	"any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lhx4^tm1Ssp/Lhx4^tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1 Allelic Composition: Golga3^{Tg(06MGMT)T604Kccri}/Golga3^{Tg(06MGMT)T604Kccri} Genetic Background: involves: C3H * C57BL/6
MP:0009647	decreased fertilization frequency	"he number of secondary oocytes each penetrated by a spermatozoon followed by fusion of the male and female pronuclei are fewer than expected" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lhx4^tm1Ssp/Lhx4^tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1
MP:0013279	increased fasted circulating glucose level	"increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr