ENSMUSG00000029554


Mus musculus

Features
Gene ID: ENSMUSG00000029554
  
Biological name :Mad1l1
  
Synonyms : Mad1l1 / Mus musculus MAD1 mitotic arrest deficient 1-like 1 (Mad1l1), transcript variant 2, mRNA. / Q9WTX8
  
Possible biological names infered from orthology : mitotic arrest deficient 1 like 1 / Q9Y6D9
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 140008689
Gene end: 140321552
  
Corresponding Affymetrix probe sets: 10535189 (MoGene1.0st)   1425252_a_at (Mouse Genome 430 2.0 Array)   1444755_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031534
Ensembl peptide - ENSMUSP00000106453
NCBI entrez gene - 17120     See in Manteia.
MGI - MGI:1341857
RefSeq - XM_006504652
RefSeq - NM_001359025
RefSeq - NM_010752
RefSeq - XM_006504651
RefSeq Peptide - NP_001345954
RefSeq Peptide - NP_034882
swissprot - Q9WTX8
Ensembl - ENSMUSG00000029554
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mad1l1ENSDARG00000033852Danio rerio
 MAD1L1ENSGALG00000004224Gallus gallus
 MAD1L1ENSG00000002822Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008672  Spindle assembly checkpoint component Mad1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007094 mitotic spindle assembly checkpoint IBA
 biological_processGO:0042130 negative regulation of T cell proliferation IDA
 biological_processGO:0048538 thymus development IDA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051315 attachment of mitotic spindle microtubules to kinetochore IBA
 biological_processGO:0090235 regulation of metaphase plate congression IEA
 biological_processGO:1901990 regulation of mitotic cell cycle phase transition IDA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore ISO
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000922 spindle pole IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope ISS
 cellular_componentGO:0005643 nuclear pore IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0072686 mitotic spindle IEA
 cellular_componentGO:0097431 mitotic spindle pole IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043515 kinetochore binding IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Htttm3Mem/Htttm3Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Mad1l1tm1.1Ktj/Mad1l1+,Mad2l1tm1Sorg/Mad2l1+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Htttm3Mem/Htttm3Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Htttm3Mem/Htttm3Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002036 rhabdomyosarcoma "malignant tumor derived from skeletal (striated) muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Htttm3Mem/Htttm3Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Htttm3Mem/Htttm3Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Htttm3Mem/Htttm3Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
Show

Allelic Composition: Htttm3Mem/Htttm3Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003789 osteosarcoma "malignant neoplasm derived from bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm3Mem/Htttm3Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004023 abnormal chromosome number "chromosome count is other than the expected diploid chromosome number" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm3Mem/Htttm3Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Mad1l1tm1.1Ktj/Mad1l1+,Mad2l1tm1Sorg/Mad2l1+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Htttm3Mem/Htttm3Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Mad1l1tm1.1Ktj/Mad1l1+,Mad2l1tm1Sorg/Mad2l1+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm3Mem/Htttm3Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Mad1l1tm1.1Ktj/Mad1l1+,Mad2l1tm1Sorg/Mad2l1+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J

 MP:0009762 abnormal mitotic spindle assembly checkpoint "an anomaly in the process that normally prevents inaccurate segregation of chromosome by inhibiting cell-cycle progression in response to a signal generated by mitotic spindle damage or by chromosomes that have not attached to microtubules" [PMID:19372138]
Show

Allelic Composition: Htttm3Mem/Htttm3Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Mad1l1tm1.1Ktj/Mad1l1+,Mad2l1tm1Sorg/Mad2l1+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Htttm3Mem/Htttm3Mem
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029910 Mad2l1 / Q9Z1B5 / Mitotic spindle assembly checkpoint protein MAD2A / Q13257* / mitotic arrest deficient 2 like 1*  / reaction / complex






 

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