ENSMUSG00000029682


Mus musculus

Features
Gene ID: ENSMUSG00000029682
  
Biological name :Spam1
  
Synonyms : P48794 / Spam1 / sperm adhesion molecule 1
  
Possible biological names infered from orthology : P38567
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: A3.1
Gene start: 24791188
Gene end: 24801048
  
Corresponding Affymetrix probe sets: 10536729 (MoGene1.0st)   1419432_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031693
Ensembl peptide - ENSMUSP00000143944
Ensembl peptide - ENSMUSP00000143970
NCBI entrez gene - 20690     See in Manteia.
MGI - MGI:109335
RefSeq - XM_006505025
RefSeq - NM_001079875
RefSeq - NM_009241
RefSeq Peptide - NP_033267
RefSeq Peptide - NP_001073344
swissprot - P48794
Ensembl - ENSMUSG00000029682
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spam1ENSDARG00000004199Danio rerio
 SPAM1ENSGALG00000008761Gallus gallus
 SPAM1ENSG00000106304Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hyal5 / Q812F3 / Hyaluronidase-5 / SPAM1* / P38567* / sperm adhesion molecule 1*ENSMUSG0000002967857
Hyal2 / O35632 / Hyaluronidase-2 / Q12891* / hyaluronoglucosaminidase 2*ENSMUSG0000001004735
Hyal4 / Q05A56 / Hyaluronidase-4 / Q2M3T9* / hyaluronoglucosaminidase 4*ENSMUSG0000002968033
Hyal6 / hyaluronoglucosaminidase 6ENSMUSG0000002967932
Hyal1 / Q91ZJ9 / Mus musculus hyaluronoglucosaminidase 1 (Hyal1), transcript variant 2, mRNA. / Q12794* / hyaluronoglucosaminidase 1*ENSMUSG0000001005131
Hyal3 / Q8VEI3 / Hyaluronidase-3 / O43820* / hyaluronoglucosaminidase 3*ENSMUSG0000003609129


Protein motifs (from Interpro)
Interpro ID Name
 IPR001439  Hyaluronidase PH20/Hyaluronidase-5
 IPR013785  Aldolase-type TIM barrel
 IPR017853  Glycoside hydrolase superfamily
 IPR018155  Hyaluronidase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007338 single fertilization IMP
 biological_processGO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization IEA
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0001669 acrosomal vesicle IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0045121 membrane raft IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004415 hyalurononglucosaminidase activity IMP
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA


Pathways (from Reactome)
Pathway description
Interaction With Cumulus Cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Spam1tm1Tba/Spam1tm1Tba
Genetic Background: Not Specified

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Spam1tm1Tba/Spam1tm1Tba
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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