ENSMUSG00000029711


Mus musculus

Features
Gene ID: ENSMUSG00000029711
  
Biological name :Epo
  
Synonyms : Epo / Erythropoietin / P07321
  
Possible biological names infered from orthology : P01588
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 137483020
Gene end: 137533242
  
Corresponding Affymetrix probe sets: 10534832 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000031723
Ensembl peptide - ENSMUSP00000106667
Ensembl peptide - ENSMUSP00000106668
NCBI entrez gene - 13856     See in Manteia.
MGI - MGI:95407
RefSeq - NM_001312875
RefSeq - NM_007942
RefSeq Peptide - NP_001299804
RefSeq Peptide - NP_031968
swissprot - Q0VED9
swissprot - P07321
swissprot - B7ZMY9
Ensembl - ENSMUSG00000029711
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 epoaENSDARG00000055163Danio rerio
 epobENSDARG00000100737Danio rerio
 EPOENSG00000130427Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001323  Erythropoietin/thrombopoeitin
 IPR003013  Erythropoietin
 IPR009079  Four-helical cytokine-like, core
 IPR019767  Erythropoietin/thrombopoeitin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001525 angiogenesis TAS
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0003007 heart morphogenesis TAS
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006915 apoptotic process IDA
 biological_processGO:0006953 acute-phase response IEA
 biological_processGO:0007566 embryo implantation IDA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009651 response to salt stress IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010523 negative regulation of calcium ion transport into cytosol IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0033033 negative regulation of myeloid cell apoptotic process IDA
 biological_processGO:0033189 response to vitamin A IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0038162 erythropoietin-mediated signaling pathway IEA
 biological_processGO:0042104 positive regulation of activated T cell proliferation IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0042541 hemoglobin biosynthetic process IDA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043249 erythrocyte maturation IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0046579 positive regulation of Ras protein signal transduction IEA
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0055008 cardiac muscle tissue morphogenesis TAS
 biological_processGO:0055010 ventricular cardiac muscle tissue morphogenesis TAS
 biological_processGO:0055093 response to hyperoxia IEA
 biological_processGO:0060979 vasculogenesis involved in coronary vascular morphogenesis TAS
 biological_processGO:0061032 visceral serous pericardium development TAS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070555 response to interleukin-1 IEA
 biological_processGO:0071474 cellular hyperosmotic response IEA
 biological_processGO:0071548 response to dexamethasone IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress IEA
 biological_processGO:1902251 negative regulation of erythrocyte apoptotic process IEA
 biological_processGO:2001258 negative regulation of cation channel activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0044297 cell body IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005128 erythropoietin receptor binding IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0030295 protein kinase activator activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Epotm1Knni/Epotm1Knni,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym
Genetic Background: Not Specified

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym,Tg(Epo*)458Mym/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1

Allelic Composition: Epotm1Knni/Epotm1Knni,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym
Genetic Background: Not Specified

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Eportm1Jae/Eportm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym,Tg(Epo*)458Mym/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0000279 ventricular hypoplasia "reduction in cell number of one or both of the two lower chambers of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Epotm1Jae/Epotm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Epotm1Jae/Epotm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Slc6a14tm1Gana/Slc6a14tm1Gana,Tg(MMTVneu)202Mul/0
Genetic Background: involves: FVB/N

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc6a14tm1Gana/Slc6a14tm1Gana,Tg(MMTVneu)202Mul/0
Genetic Background: involves: FVB/N

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Bsndtm1.1Suc/Bsndtm1.1Suc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym
Genetic Background: Not Specified

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym
Genetic Background: Not Specified

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym
Genetic Background: Not Specified

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Slc6a14tm1Gana/Slc6a14tm1Gana,Tg(MMTVneu)202Mul/0
Genetic Background: involves: FVB/N

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1

Allelic Composition: EpoTg(SV40T/Epo)134.3LCPjr/Epo+
Genetic Background: (C57BL/10 x CBA)F1 X CFLP

Allelic Composition: EpoTg(SV40T/Epo)134.3LCPjr/EpoTg(SV40T/Epo)134.3LCPjr
Genetic Background: (C57BL/10 x CBA)F1 X CFLP

Allelic Composition: EpoTg(SV40T/Epo)134.3LCPjr/EpoTg(SV40T/Epo)134.3LCPjr
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: EpoTg(SV40T/Epo)134.3LCPjr/Epo+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Epotm1Jae/Epotm1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym
Genetic Background: Not Specified

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym,Tg(Epo*)458Mym/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym,Tg(Epo*)458Mym/Tg(Epo*)458Mym
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eportm1Jae/Eportm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Eportm1Jae/Eportm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
Show

Allelic Composition: Eportm1Jae/Eportm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym
Genetic Background: Not Specified

 MP:0002319 hyperoxia "elevated concentration of O2 in the blood, alveoli or other tissues resulting in the increased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: EpoTg(SV40T/Epo)134.3LCPjr/EpoTg(SV40T/Epo)134.3LCPjr
Genetic Background: involves: C57BL/6 * CBA

 MP:0002320 hyperventilation "increased alveolar ventilation relative to metabolic carbon dioxide production; results in carbon dioxide pressure decreasing below normal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: EpoTg(SV40T/Epo)134.3LCPjr/EpoTg(SV40T/Epo)134.3LCPjr
Genetic Background: involves: C57BL/6 * CBA

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: EpoTg(SV40T/Epo)134.3LCPjr/EpoTg(SV40T/Epo)134.3LCPjr
Genetic Background: involves: C57BL/6 * CBA

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Epotm1Knni/Epotm1Knni,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Med12tm1.1Hsch/Med12tm1.1Hsch
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

Allelic Composition: Epotm1Knni/Epotm1Knni,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Epotm1Jae/Epotm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0003057 abnormal epicardium morphology "anomalous structure of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Epotm1Jae/Epotm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Epotm1.2Mym/Epotm1.2Mym
Genetic Background: Not Specified

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1

 MP:0003913 increased right ventricle weight "greater than average weight of the right ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: EpoTg(SV40T/Epo)134.3LCPjr/EpoTg(SV40T/Epo)134.3LCPjr
Genetic Background: involves: C57BL/6 * CBA

 MP:0003915 increased left ventricle weight "greater than average weight of the left ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: EpoTg(SV40T/Epo)134.3LCPjr/EpoTg(SV40T/Epo)134.3LCPjr
Genetic Background: involves: C57BL/6 * CBA

 MP:0004032 abnormal interventricular groove "malformation of the intendation dividing the two ventricles, comprised of the sulcus interventricularis anterior and the sulcus interventricularis posterior" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Epotm1Jae/Epotm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Epotm1Jae/Epotm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: EpoTg(SV40T/Epo)134.3LCPjr/EpoTg(SV40T/Epo)134.3LCPjr
Genetic Background: involves: C57BL/6 * CBA

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: EpoTg(SV40T/Epo)134.3LCPjr/EpoTg(SV40T/Epo)134.3LCPjr
Genetic Background: involves: C57BL/6 * CBA

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: EpoTg(SV40T/Epo)134.3LCPjr/EpoTg(SV40T/Epo)134.3LCPjr
Genetic Background: involves: C57BL/6 * CBA

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: EpoTg(SV40T/Epo)134.3LCPjr/EpoTg(SV40T/Epo)134.3LCPjr
Genetic Background: involves: C57BL/6 * CBA

 MP:0005575 increased pulmonary ventilation "greater than the normal total volume of gas per minute inspired or expired " [RGD:Rat Genome Database submission]
Show

Allelic Composition: EpoTg(SV40T/Epo)134.3LCPjr/EpoTg(SV40T/Epo)134.3LCPjr
Genetic Background: involves: C57BL/6 * CBA

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Epotm1Jae/Epotm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0005639 hemosiderosis "condition in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the reticuloendothelial system, without demonstrable tissue damage" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: EpoTg(SV40T/Epo)134.3LCPjr/EpoTg(SV40T/Epo)134.3LCPjr
Genetic Background: involves: C57BL/6 * CBA

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Med12tm1.1Hsch/Med12tm1.1Hsch
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1

Allelic Composition: Epotm1Jae/Epotm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0011179 decreased erythroblast number "reduced number of the nucleated precursor of erythrocytes" [MGI:csmith]
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Allelic Composition: Epotm1.2Mym/Epotm1.2Mym,Tg(Epo*)458Mym/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0011243 decreased fetal derived definitive erythrocyte cell number "reduced number of fetal liver derived enucleated erythrocytes, which mature in macrophage islands within the liver, enucleate, and then enter the bloodstream; these resemble adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemoglobins" [CL:0002357, PMID:18282515]
Show

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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