ENSMUSG00000029763


Mus musculus

Features
Gene ID: ENSMUSG00000029763
  
Biological name :Exoc4
  
Synonyms : Exoc4 / Mus musculus exocyst complex component 4 (Exoc4), transcript variant 2, mRNA. / O35382
  
Possible biological names infered from orthology : exocyst complex component 4 / Q96A65
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: A3.3
Gene start: 33249085
Gene end: 33973979
  
Corresponding Affymetrix probe sets: 10537102 (MoGene1.0st)   1422684_a_at (Mouse Genome 430 2.0 Array)   1422685_at (Mouse Genome 430 2.0 Array)   1422686_s_at (Mouse Genome 430 2.0 Array)   1431062_a_at (Mouse Genome 430 2.0 Array)   1453977_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000051965
Ensembl peptide - ENSMUSP00000087859
Ensembl peptide - ENSMUSP00000110732
NCBI entrez gene - 20336     See in Manteia.
MGI - MGI:1096376
RefSeq - XM_011241263
RefSeq - NM_001347089
RefSeq - NM_009148
RefSeq - XM_011241262
RefSeq Peptide - NP_001334018
RefSeq Peptide - NP_033174
swissprot - O35382
swissprot - Q8C391
swissprot - Q9CXE1
Ensembl - ENSMUSG00000029763
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 exoc4ENSDARG00000004336Danio rerio
 EXOC4ENSGALG00000008477Gallus gallus
 EXOC4ENSG00000131558Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007191  Sec8 exocyst complex component specific domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006612 protein targeting to membrane IBA
 biological_processGO:0006887 exocytosis IBA
 biological_processGO:0006893 Golgi to plasma membrane transport IBA
 biological_processGO:0006903 vesicle targeting IBA
 biological_processGO:0006904 vesicle docking involved in exocytosis IEA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0048341 paraxial mesoderm formation IMP
 cellular_componentGO:0000145 exocyst IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005902 microvillus IDA
 cellular_componentGO:0032584 growth cone membrane IDA
 cellular_componentGO:0035748 myelin sheath abaxonal region IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse IBA
 cellular_componentGO:0090543 Flemming body IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017160 Ral GTPase binding IEA
 molecular_functionGO:0030165 PDZ domain binding IPI
 molecular_functionGO:0047485 protein N-terminus binding IEA


Pathways (from Reactome)
Pathway description
Insulin processing
VxPx cargo-targeting to cilium


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dolkem1(IMPC)J/Dolkem1(IMPC)J
Genetic Background: C57BL/6NJ-Dolkem1(IMPC)J/J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dolkem1(IMPC)J/Dolkem1(IMPC)J
Genetic Background: C57BL/6NJ-Dolkem1(IMPC)J/J

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dolkem1(IMPC)J/Dolkem1(IMPC)J
Genetic Background: C57BL/6NJ-Dolkem1(IMPC)J/J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Dolkem1(IMPC)J/Dolkem1(IMPC)J
Genetic Background: C57BL/6NJ-Dolkem1(IMPC)J/J

 MP:0012105 delayed gastrulation "late onset of the development and invagination of the embryonic germ layers" [MGI:anna]
Show

Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0012131 small visceral yolk sac "reduced size of the extraembryonic tissue membrane, formed from the visceral endoderm and the extraembryonic mesoderm, which is located ventral to the embryonic disc and is connected to the presumptive midgut of the embryo" [MGI:anna]
Show

Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0012142 absent amniotic cavity "absence of the closed space between the embryo and the amnion which contains the amniotic fluid and is formed by the fusion of the parts of the anterior and posterior amniotic folds" [MGI:anna]
Show

Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0012183 decreased paraxial mesoderm size "reduced size or deficiency of the mesoderm lying at either side of the midline embryonic notochord that, on segmentation, forms the paired somites" [MGI:anna]
Show

Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Dolkem1(IMPC)J/Dolkem1(IMPC)J
Genetic Background: C57BL/6NJ-Dolkem1(IMPC)J/J

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Dolkem1(IMPC)J/Dolkem1(IMPC)J
Genetic Background: C57BL/6NJ-Dolkem1(IMPC)J/J

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Dolkem1(IMPC)J/Dolkem1(IMPC)J
Genetic Background: C57BL/6NJ-Dolkem1(IMPC)J/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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