ENSMUSG00000029810


Mus musculus

Features
Gene ID: ENSMUSG00000029810
  
Biological name :Tmem176b
  
Synonyms : Q9R1Q6 / Tmem176b / Transmembrane protein 176B
  
Possible biological names infered from orthology : Q3YBM2
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B2.3
Gene start: 48833818
Gene end: 48841496
  
Corresponding Affymetrix probe sets: 10544596 (MoGene1.0st)   1418004_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144865
Ensembl peptide - ENSMUSP00000144864
Ensembl peptide - ENSMUSP00000144869
Ensembl peptide - ENSMUSP00000145395
Ensembl peptide - ENSMUSP00000145235
Ensembl peptide - ENSMUSP00000144949
Ensembl peptide - ENSMUSP00000098972
Ensembl peptide - ENSMUSP00000128705
Ensembl peptide - ENSMUSP00000131064
Ensembl peptide - ENSMUSP00000144742
Ensembl peptide - ENSMUSP00000144810
NCBI entrez gene - 65963     See in Manteia.
MGI - MGI:1916348
RefSeq - XM_017321710
RefSeq - NM_001164207
RefSeq - NM_001164208
RefSeq - NM_001164209
RefSeq - NM_001286651
RefSeq - NM_001286652
RefSeq - NM_023056
RefSeq - XM_006506456
RefSeq - XM_006506457
RefSeq - XM_006506458
RefSeq - XM_006506459
RefSeq - XM_006506460
RefSeq - XM_006506461
RefSeq Peptide - NP_001157680
RefSeq Peptide - NP_001157681
RefSeq Peptide - NP_001273580
RefSeq Peptide - NP_001273581
RefSeq Peptide - NP_075543
RefSeq Peptide - NP_001157679
swissprot - A0A0N4SUM7
swissprot - A0A0N4SV46
swissprot - A0A0N4SUY1
swissprot - A0A0N4SUS9
swissprot - A0A0N4SVT4
swissprot - Q9R1Q6
Ensembl - ENSMUSG00000029810
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q3YBM2ENSG00000106565Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9DCS1 / Tmem176a / Transmembrane protein 176A / Q96HP8*ENSMUSG0000002336725


Protein motifs (from Interpro)
Interpro ID Name
 IPR007237  CD20-like family
 IPR009281  Transmembrane protein 176A/B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:2001199 negative regulation of dendritic cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: Lrp5tm1Kry/Lrp5+
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lrp5tm1Kry/Lrp5+
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
Show

Allelic Composition: Lrp5tm1Kry/Lrp5+
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrp5tm1Kry/Lrp5+
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lrp5tm1Kry/Lrp5+
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Lrp5tm1Kry/Lrp5+
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Lrp5tm1Kry/Lrp5+
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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