ENSMUSG00000029913


Mus musculus

Features
Gene ID: ENSMUSG00000029913
  
Biological name :Prdm5
  
Synonyms : Prdm5 / PR domain containing 5 / Q9CXE0
  
Possible biological names infered from orthology : PR/SET domain 5 / Q9NQX1
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C1
Gene start: 65778988
Gene end: 65937010
  
Corresponding Affymetrix probe sets: 10538811 (MoGene1.0st)   1432057_a_at (Mouse Genome 430 2.0 Array)   1442740_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031973
Ensembl peptide - ENSMUSP00000031976
Ensembl peptide - ENSMUSP00000079979
Ensembl peptide - ENSMUSP00000133423
NCBI entrez gene - 70779     See in Manteia.
MGI - MGI:1918029
RefSeq - XM_011241464
RefSeq - NM_027547
RefSeq - XM_006506601
RefSeq - XM_006506602
RefSeq - XM_006506604
RefSeq Peptide - NP_081823
RefSeq Peptide - NP_083825
swissprot - Q9CXE0
swissprot - Q9D1T8
swissprot - G3UWU3
swissprot - E9Q707
Ensembl - ENSMUSG00000029913
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prdm5ENSDARG00000006288Danio rerio
 PRDM5ENSGALG00000011963Gallus gallus
 PRDM5ENSG00000138738Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR017125  PR-domain zinc finger protein PRDM5-like
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0051567 histone H3-K9 methylation IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
Show

Allelic Composition: Kcnq1ot1tm2.1Ckan/Kcnq1ot1+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SD7

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Kcnq1ot1tm2.1Ckan/Kcnq1ot1+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SD7

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Kcnq1ot1tm2.1Ckan/Kcnq1ot1+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SD7

 MP:0004986 abnormal osteoblast morphology "any structural anomaly of a bone-forming cell, which normally forms an osseous matrix (osteoid) in which it becomes enclosed as an osteocyte" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnq1ot1tm2.1Ckan/Kcnq1ot1+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SD7

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnq1ot1tm2.1Ckan/Kcnq1ot1+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SD7

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnq1ot1tm2.1Ckan/Kcnq1ot1+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SD7

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnq1ot1tm2.1Ckan/Kcnq1ot1+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SD7

 MP:0010965 decreased compact bone volume 
Show

Allelic Composition: Kcnq1ot1tm2.1Ckan/Kcnq1ot1+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SD7

 MP:0011642 abnormal bone collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity" [MGI:csmith]
Show

Allelic Composition: Kcnq1ot1tm2.1Ckan/Kcnq1ot1+,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SD7

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr