ENSMUSG00000030060


Mus musculus

Features
Gene ID: ENSMUSG00000030060
  
Biological name :Hmces
  
Synonyms : Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein / Hmces / Q8R1M0
  
Possible biological names infered from orthology : 5-hydroxymethylcytosine binding, ES cell specific / Q96FZ2
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: D1
Gene start: 87913935
Gene end: 87936629
  
Corresponding Affymetrix probe sets: 10539850 (MoGene1.0st)   1423786_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109236
Ensembl peptide - ENSMUSP00000145504
Ensembl peptide - ENSMUSP00000032141
NCBI entrez gene - 232210     See in Manteia.
MGI - MGI:1914053
RefSeq - NM_173737
RefSeq Peptide - NP_776098
swissprot - A0A0N4SWG0
swissprot - Q8R1M0
Ensembl - ENSMUSG00000030060
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hmcesENSDARG00000077471Danio rerio
 HMCESENSGALG00000005897Gallus gallus
 HMCESENSG00000183624Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003738  SOS response associated peptidase (SRAP)
 IPR036590  SOS response associated peptidase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0008150 biological_process ND
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Depdc5tm1c(EUCOMM)Hmgu/Depdc5+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6N * CBA

Allelic Composition: Hmcesem2Dfel/Hmcesem2Dfel
Genetic Background: involves: 129 * C57BL/6N

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Depdc5tm1c(EUCOMM)Hmgu/Depdc5+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6N * CBA

Allelic Composition: Hmcesem2Dfel/Hmcesem2Dfel
Genetic Background: involves: 129 * C57BL/6N

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
Show

Allelic Composition: Depdc5tm1c(EUCOMM)Hmgu/Depdc5+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6N * CBA

Allelic Composition: Hmcesem2Dfel/Hmcesem2Dfel
Genetic Background: involves: 129 * C57BL/6N

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Depdc5tm1c(EUCOMM)Hmgu/Depdc5+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6N * CBA

Allelic Composition: Hmcesem1Dfel/Hmces+
Genetic Background: involves: 129 * C57BL/6N

Allelic Composition: Hmcesem2Dfel/Hmcesem2Dfel
Genetic Background: involves: 129 * C57BL/6N

Allelic Composition: Hmcesem2Dfel/Hmces+
Genetic Background: involves: 129 * C57BL/6N

 MP:0011104 partial embryonic lethality before implantation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Depdc5tm1c(EUCOMM)Hmgu/Depdc5+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6N * CBA

Allelic Composition: Hmcesem2Dfel/Hmcesem2Dfel
Genetic Background: involves: 129 * C57BL/6N

 MP:0012167 abnormal epigenetic regulation of gene expression "any anomaly in the process that modulates the frequency, rate or extent of gene expression, in which the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence" [GO:0040029]
Show

Allelic Composition: Depdc5tm1c(EUCOMM)Hmgu/Depdc5+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6N * CBA

Allelic Composition: Hmcesem2Dfel/Hmcesem2Dfel
Genetic Background: involves: 129 * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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