ENSMUSG00000030156


Mus musculus

Features
Gene ID: ENSMUSG00000030156
  
Biological name :Cd69
  
Synonyms : Cd69 / Early activation antigen CD69 / P37217
  
Possible biological names infered from orthology : CD69 molecule / Q07108
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F3
Gene start: 129267325
Gene end: 129275436
  
Corresponding Affymetrix probe sets: 10548333 (MoGene1.0st)   1428735_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032259
Ensembl peptide - ENSMUSP00000144734
NCBI entrez gene - 12515     See in Manteia.
MGI - MGI:88343
RefSeq - XM_006505463
RefSeq - NM_001033122
RefSeq Peptide - NP_001028294
swissprot - P37217
swissprot - Q3U6A8
swissprot - A0A0N4SUM0
Ensembl - ENSMUSG00000030156
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000045134Gallus gallus
 ENSGALG00000039340Gallus gallus
 ENSGALG00000046229Gallus gallus
 ENSGALG00000044598Gallus gallus
 ENSGALG00000045053Gallus gallus
 ENSGALG00000045540Gallus gallus
 ENSGALG00000044633Gallus gallus
 ENSGALG00000045880Gallus gallus
 ENSGALG00000045290Gallus gallus
 ENSGALG00000044569Gallus gallus
 ENSGALG00000045081Gallus gallus
 BLEC1ENSGALG00000028659Gallus gallus
 BLEC3ENSGALG00000031092Gallus gallus
 Y-LEC1ENSGALG00000042684Gallus gallus
 CD69ENSG00000110848Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clec2l / P0C7M9 / C-type lectin domain family 2 member L / P0C7M8*ENSMUSG0000007959827
Clec2g / Q9D676 / C-type lectin domain family 2 member G ENSMUSG0000000024826
Clec2eENSMUSG0000003015526
Clec2i / Q9WVF9 / C-type lectin domain family 2 member I ENSMUSG0000003036525
Clec2h / Q8C1T8 / C-type lectin domain family 2 member H ENSMUSG0000003036425
Clec2d / Q91V08 / C-type lectin domain family 2 member D ENSMUSG0000003015723
Klrg1 / O88713 / Killer cell lectin-like receptor subfamily G member 1 / Q96E93* / killer cell lectin like receptor G1*ENSMUSG0000003011420
Klrg2 / killer cell lectin like receptor G2 / A4D1S0*ENSMUSG0000007153720
4922502D21Rik / RIKEN cDNA 4922502D21 geneENSMUSG0000004772019


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR033992  Natural killer cell receptor-like, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035690 cellular response to drug IEP
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

Allelic Composition: Cd69tm1Naka/Cd69tm1Naka
Genetic Background: B6.129P2-Cd69tm1Naka

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd69tm1Naka/Cd69tm1Naka
Genetic Background: B6.129P2-Cd69tm1Naka

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
Show

Allelic Composition: Gjc2tm1Paul/Gjc2tm1Paul,Gjb1tm1Kwi/Gjb1tm1Kwi
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd69tm1Naka/Cd69tm1Naka
Genetic Background: B6.129P2-Cd69tm1Naka

 MP:0008051 abnormal memory T cell physiology "any functional anomaly of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd69tm1Naka/Cd69tm1Naka
Genetic Background: B6.129P2-Cd69tm1Naka

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd69tm1Naka/Cd69tm1Naka
Genetic Background: B6.129P2-Cd69tm1Naka

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Cd69tm1Naka/Cd69tm1Naka
Genetic Background: B6.129P2-Cd69tm1Naka

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Cd69tm1Naka/Cd69tm1Naka
Genetic Background: B6.129P2-Cd69tm1Naka

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gjc2tm1Paul/Gjc2tm1Paul,Gjb1tm1Kwi/Gjb1tm1Kwi
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gjc2tm1Paul/Gjc2tm1Paul,Gjb1tm1Kwi/Gjb1tm1Kwi
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr