ENSMUSG00000030218


Mus musculus

Features
Gene ID: ENSMUSG00000030218
  
Biological name :Mgp
  
Synonyms : matrix Gla protein / Mgp / P19788
  
Possible biological names infered from orthology : P08493
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: G1
Gene start: 136872435
Gene end: 136875823
  
Corresponding Affymetrix probe sets: 10548879 (MoGene1.0st)   1448416_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032342
NCBI entrez gene - 17313     See in Manteia.
MGI - MGI:96976
RefSeq - NM_008597
RefSeq Peptide - NP_032623
swissprot - P19788
Ensembl - ENSMUSG00000030218
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MGPENSGALG00000011740Gallus gallus
 MGPENSG00000111341Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000294  Gamma-carboxyglutamic acid-rich (GLA) domain
 IPR002384  Osteocalcin/matrix Gla protein
 IPR027118  Matrix Gla protein
 IPR035972  Gamma-carboxyglutamic acid-rich (GLA) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030500 regulation of bone mineralization IEA
 biological_processGO:0051216 cartilage development IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0031012 extracellular matrix IBA
 molecular_functionGO:0005201 extracellular matrix structural constituent IBA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mgptm1Kry/Mgptm1Kry,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: Black Swiss * C57BL/6J

 MP:0000530 abnormal kidney vasculature "malformation or malfunctioning of the blood vessel network of the organ of excretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001255 decreased body height "decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Mastltm1.1Mama/Mastltm1.1Mama
Genetic Background: Not Specified

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Mgptm1Kry/Mgptm1Kry,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: Black Swiss * C57BL/6J

Allelic Composition: Mgptm1Kry/Mgptm1Kry,Spp1tm1Blh/Spp1+
Genetic Background: involves: Black Swiss * C57BL/6J

Allelic Composition: Mgptm1Kry/Mgp+,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: Black Swiss * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Mgptm1Kry/Mgptm1Kry,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: Black Swiss * C57BL/6J

Allelic Composition: Mgptm1Kry/Mgptm1Kry,Spp1tm1Blh/Spp1+
Genetic Background: involves: Black Swiss * C57BL/6J

Allelic Composition: Mgptm1Kry/Mgp+,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: Black Swiss * C57BL/6J

 MP:0002191 abnormal artery morphology "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mastltm1.1Mama/Mastltm1.1Mama
Genetic Background: Not Specified

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002998 abnormal bone remodeling "aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mastltm1.1Mama/Mastltm1.1Mama
Genetic Background: Not Specified

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003120 abnormal tracheal cartilage "any structural anomaly of the cartilaginous structures that support the trachea" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:97123]
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Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003211 abnormal aorta elastic fiber morphology "malformation of a slender connective tissue fiber in aortic tissue characterized by great elasticity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003279 aneurysm "a protruding sac formed by the dilation of the wall of an artery, a vein, or the heart resulting from a weakening of the vessel wall or heart muscle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Mgptm1Kry/Mgptm1Kry,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: Black Swiss * C57BL/6J

 MP:0003409 decreased width of hypertrophic chondrocyte zone "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mgptm1Kry/Mgptm1Kry
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mastltm1.1Mama/Mastltm1.1Mama
Genetic Background: Not Specified

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0006093 arteriovenous malformation "fusion of an artery and vein without an intervening capillary bed" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93125]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0006116 aortic valve calcification "pathologic deposition of calcium salts in the aortic valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0006133 arterial calcification "pathologic deposition of calcium salts in the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Mgptm1Kry/Mgptm1Kry,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: Black Swiss * C57BL/6J

Allelic Composition: Mgptm1Kry/Mgptm1Kry,Spp1tm1Blh/Spp1+
Genetic Background: involves: Black Swiss * C57BL/6J

Allelic Composition: Mgptm1Kry/Mgp+,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: Black Swiss * C57BL/6J

Allelic Composition: Mgptm1Kry/Mgptm1Kry
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Elntm1Dyl/Eln+,Mgptm1Kry/Mgptm1Kry
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0006395 abnormal epiphyseal plate morphology "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]
Show

Allelic Composition: Mgptm1Kry/Mgptm1Kry
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Elntm1Dyl/Eln+,Mgptm1Kry/Mgptm1Kry
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mgptm1Kry/Mgptm1Kry
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mgptm1Kry/Mgptm1Kry
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009865 abnormal aorta smooth muscle morphology "any structural anomaly of the nonstriated, involuntary muscle tissue located in the wall of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0009873 abnormal aorta tunica media morphology "any structural anomaly of the middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0010480 pulmonary arteriovenous malformation "abnormal communications between the pulmonary arteries and the pulmonary veins, or between a bronchial artery and the pulmonary vein" [http://emedicine.medscape.com]
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Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mgptm1Kry/Mgptm1Kry
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010873 decreased trabecular bone mass "reduced total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mgptm1Kry/Mgptm1Kry
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mgptm1Kry/Mgptm1Kry
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010962 decreased compact bone mass 
Show

Allelic Composition: Mgptm1Kry/Mgptm1Kry
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010988 abnormal bronchial cartilage morphology "any structural anomaly of the hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011320 abnormal glomerular capillary morphology "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011922 abnormal circulating osteocalcin level "aberrant concentration in the blood of this hormone secreted by osteoblasts which are found in bone and dentin" [MPD:Molly]
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Allelic Composition: Mgptm1Kry/Mgptm1Kry
Genetic Background: involves: 129S7/SvEvBrd

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Mgptm1Kry/Mgptm1Kry
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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