ENSMUSG00000030256


Mus musculus

Features
Gene ID: ENSMUSG00000030256
  
Biological name :Bhlhe41
  
Synonyms : Bhlhe41 / Class E basic helix-loop-helix protein 41 / Q99PV5
  
Possible biological names infered from orthology : basic helix-loop-helix family member e41 / Q9C0J9
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: G3
Gene start: 145858243
Gene end: 145865558
  
Corresponding Affymetrix probe sets: 10549276 (MoGene1.0st)   1421099_at (Mouse Genome 430 2.0 Array)   1457096_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032386
Ensembl peptide - ENSMUSP00000107332
NCBI entrez gene - 79362     See in Manteia.
MGI - MGI:1930704
RefSeq - NM_001271768
RefSeq - NM_024469
RefSeq Peptide - NP_001258697
RefSeq Peptide - NP_077789
swissprot - Q99PV5
swissprot - Q6L8F5
swissprot - D3Z2G6
Ensembl - ENSMUSG00000030256
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bhlhe41ENSDARG00000041691Danio rerio
 BHLHE41ENSGALG00000041414Gallus gallus
 Q9C0J9ENSG00000123095Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O35185 / Bhlhe40 / Class E basic helix-loop-helix protein 40 / O14503* / basic helix-loop-helix family member e40*ENSMUSG0000003010341


Protein motifs (from Interpro)
Interpro ID Name
 IPR003650  Orange domain
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0010832 negative regulation of myotube differentiation IDA
 biological_processGO:0010944 negative regulation of transcription by competitive promoter binding IDA
 biological_processGO:0032922 circadian regulation of gene expression IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0048511 rhythmic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0017053 transcriptional repressor complex TAS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IPI
 molecular_functionGO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0042826 histone deacetylase binding IDA
 molecular_functionGO:0043425 bHLH transcription factor binding IEA
 molecular_functionGO:0043426 MRF binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Chrm1tm2.1Stl/Chrm1tm2.1Stl,Tg(Grik4-cre)G32-4Stl/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chrm1tm2.1Stl/Chrm1tm2.1Stl,Tg(Grik4-cre)G32-4Stl/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Chrm1tm2.1Stl/Chrm1tm2.1Stl,Tg(Grik4-cre)G32-4Stl/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Chrm1tm2.1Stl/Chrm1tm2.1Stl,Tg(Grik4-cre)G32-4Stl/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Chrm1tm2.1Stl/Chrm1tm2.1Stl,Tg(Grik4-cre)G32-4Stl/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008092 abnormal T-helper 2 cell differentiation "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chrm1tm2.1Stl/Chrm1tm2.1Stl,Tg(Grik4-cre)G32-4Stl/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Chrm1tm2.1Stl/Chrm1tm2.1Stl,Tg(Grik4-cre)G32-4Stl/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008673 decreased interleukin-13 secretion "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
Show

Allelic Composition: Chrm1tm2.1Stl/Chrm1tm2.1Stl,Tg(Grik4-cre)G32-4Stl/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Chrm1tm2.1Stl/Chrm1tm2.1Stl,Tg(Grik4-cre)G32-4Stl/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Chrm1tm2.1Stl/Chrm1tm2.1Stl,Tg(Grik4-cre)G32-4Stl/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Chrm1tm2.1Stl/Chrm1tm2.1Stl,Tg(Grik4-cre)G32-4Stl/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008703 decreased interleukin-5 secretion "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
Show

Allelic Composition: Chrm1tm2.1Stl/Chrm1tm2.1Stl,Tg(Grik4-cre)G32-4Stl/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
Show

Allelic Composition: Nr2e3tm1Dgen/Nr2e3tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Bhlhe40tm1Tan/Bhlhe40tm1Tan,Bhlhe41tm1Mjro/Bhlhe41+
Genetic Background: B6.129-Bhlhe40tm1Tan Bhlhe41tm1Mjro

Allelic Composition: Bhlhe40tm1Tan/Bhlhe40+,Bhlhe41tm1Mjro/Bhlhe41tm1Mjro
Genetic Background: B6.129-Bhlhe40tm1Tan Bhlhe41tm1Mjro

 MP:0020475 delayed circadian behavior phase "decrease in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb]
Show

Allelic Composition: Nr2e3tm1Dgen/Nr2e3tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Bhlhe40tm1Tan/Bhlhe40tm1Tan,Bhlhe41tm1Mjro/Bhlhe41tm1Mjro
Genetic Background: B6.129-Bhlhe40tm1Tan Bhlhe41tm1Mjro

Allelic Composition: Bhlhe40tm1Tan/Bhlhe40tm1Tan,Bhlhe41tm1Mjro/Bhlhe41+
Genetic Background: B6.129-Bhlhe40tm1Tan Bhlhe41tm1Mjro

Allelic Composition: Bhlhe40tm1Tan/Bhlhe40+,Bhlhe41tm1Mjro/Bhlhe41tm1Mjro
Genetic Background: B6.129-Bhlhe40tm1Tan Bhlhe41tm1Mjro

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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