ENSMUSG00000030303


Mus musculus

Features
Gene ID: ENSMUSG00000030303
  
Biological name :Far2
  
Synonyms : Far2 / Mus musculus fatty acyl CoA reductase 2 (Far2), transcript variant 1, mRNA. / Q7TNT2
  
Possible biological names infered from orthology : fatty acyl-CoA reductase 2 / Q96K12
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: G3
Gene start: 148047259
Gene end: 148182758
  
Corresponding Affymetrix probe sets: 10542857 (MoGene1.0st)   1435621_at (Mouse Genome 430 2.0 Array)   1455889_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032443
Ensembl peptide - ENSMUSP00000107234
NCBI entrez gene - 330450     See in Manteia.
MGI - MGI:2687035
RefSeq - XM_006507070
RefSeq - NM_001347516
RefSeq - NM_178797
RefSeq - XM_006507069
RefSeq Peptide - NP_001334445
RefSeq Peptide - NP_848912
swissprot - Q7TNT2
Ensembl - ENSMUSG00000030303
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-97m3.1ENSDARG00000009262Danio rerio
 FAR2ENSGALG00000017291Gallus gallus
 FAR2ENSG00000064763Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Far1 / Q922J9 / Fatty acyl-CoA reductase 1 / Q8WVX9*ENSMUSG0000003075957


Protein motifs (from Interpro)
Interpro ID Name
 IPR013120  Male sterility, NAD-binding
 IPR026055  Fatty acyl-CoA reductase
 IPR033640  Fatty acyl-CoA reductase, C-terminal
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0010025 wax biosynthetic process TAS
 biological_processGO:0035336 long-chain fatty-acyl-CoA metabolic process ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005777 peroxisome IDA
 cellular_componentGO:0005778 peroxisomal membrane IEA
 cellular_componentGO:0005779 integral component of peroxisomal membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity ISO
 molecular_functionGO:0102965 alcohol-forming fatty acyl-CoA reductase activity IEA


Pathways (from Reactome)
Pathway description
Wax biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0003929 decreased heart rate variability "reduced variation of beat-to-beat intervals of the heart, usually indicitive of cardiac disease" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0005385 cardiovascular system phenotype 
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Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0010507 shortened RR interval "reduction in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
Show

Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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