ENSMUSG00000030380


Mus musculus

Features
Gene ID: ENSMUSG00000030380
  
Biological name :Mzf1
  
Synonyms : myeloid zinc finger 1 / Mzf1
  
Possible biological names infered from orthology : P28698
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A1
Gene start: 13042303
Gene end: 13054764
  
Corresponding Affymetrix probe sets: 10560078 (MoGene1.0st)   1420738_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069122
Ensembl peptide - ENSMUSP00000138163
Ensembl peptide - ENSMUSP00000138271
Ensembl peptide - ENSMUSP00000138387
NCBI entrez gene - 109889     See in Manteia.
MGI - MGI:107457
RefSeq - XM_017321928
RefSeq - NM_001290452
RefSeq - NM_001290453
RefSeq - NM_145819
RefSeq - XM_006539465
RefSeq - XM_006539466
RefSeq - XM_006539469
RefSeq - XM_011250413
RefSeq Peptide - NP_001277381
RefSeq Peptide - NP_001277382
RefSeq Peptide - NP_665818
swissprot - F6VC78
swissprot - A1L358
swissprot - S4R1C2
swissprot - S4R1L6
Ensembl - ENSMUSG00000030380
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MZF1ENSG00000099326Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3URR7 / Zscan10 / zinc finger and SCAN domain containing 10 / Q96SZ4*ENSMUSG0000002390234


Protein motifs (from Interpro)
Interpro ID Name
 IPR003309  SCAN domain
 IPR008916  Retrovirus capsid, C-terminal
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 cellular_componentGO:0005634 nucleus ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000168 abnormal bone marrow development "malformation or anomalous differentiation of the soft, pulpy tissue filling the medullary cavities of bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Snai2tm1Look/Snai2tm1Look
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Snai2tm1Look/Snai2tm1Look
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Snai2tm1Look/Snai2tm1Look
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Snai2tm1Look/Snai2tm1Look
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Snai2tm1Look/Snai2tm1Look
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005649 spleen neoplasm "abnormal new cellular growth of the spleen" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:70407]
Show

Allelic Composition: Snai2tm1Look/Snai2tm1Look
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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