Manteia

ID	Phenotype	Definition	Genetic BG
MP:0000013	abnormal fat distribution	"alterations in the normal placement and amount of body fat" [J:57315]	Show Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000066	osteoporosis	"reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh},Xpa^tm1Hvs/Xpa^tm1Hvs Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000160	kyphosis	"forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh},Xpa^tm1Hvs/Xpa^tm1Hvs Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000313	abnormal cell death	"anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000367	abnormal coat/ hair morphology	"anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv
MP:0000377	abnormal hair follicle	"malformed invagination of the epidermis from which the hair shaft develops" [J:65031]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh},Xpa^tm1Hvs/Xpa^tm1Hvs Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000381	enlarged hair follicles	"increased size of the epidermal invaginations from which the hair shaft develops" [J:30249]	Show Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000414	alopecia	"absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000416	sparse fur	"fur that is significantly less dense" [J:46854]	Show Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000647	abnormal sebaceous gland morphology	"malformation of the holocrine glands of the dermis that secrete sebum into the hair follicles" [MGI:tc]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv
MP:0000652	enlarged sebaceous gland	"increased size of the sebum secreting glands of the hair shaft" [J:30249]	Show Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ercc2^tm3Jhjh/Ercc2^tm3Jhjh,Xpa^tm1Hvs/Xpa^tm1Hvs Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
MP:0000876	Purkinje cell degeneration	"a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]	Show Allelic Composition: Ercc2^tm3Jhjh/Ercc2^tm3Jhjh,Xpa^tm1Hvs/Xpa^tm1Hvs Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
MP:0001146	abnormal testis morphology	"anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ercc2^tm3Jhjh/Ercc2^tm3Jhjh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
MP:0001190	reddish skin	"skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]	Show Allelic Composition: Ercc2^tm3Jhjh/Ercc2^tm3Jhjh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
MP:0001192	scaly skin	"skin covered with shedding scales or flakes" [J:65146]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001200	thick skin	"greater depth of skin " [J:47225]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001202	skin photosensitivity	"abnormally heightened reactivity of the skin to sunlight " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ercc2^tm3Jhjh/Ercc2^tm3Jhjh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
MP:0001239	abnormal granular layer morphology	"structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001242	hyperkeratosis	"increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh},Xpa^tm1Hvs/Xpa^tm1Hvs Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Zfhx3^Sci/Zfhx3^Sci Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
MP:0001297	microphthalmia	"reduced average size of the eyes" [J:18048]	Show Allelic Composition: Zfhx3^Sci/Zfhx3^Sci Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
MP:0001303	abnormal lens morphology	"malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]	Show Allelic Composition: Zfhx3^Sci/Zfhx3^Sci Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
MP:0001304	cataracts	"complete or partial opacity of the lens" [J:65031]	Show Allelic Composition: Zfhx3^Sci/Zfhx3^Sci Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
MP:0001306	small lens	"reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Zfhx3^Sci/Zfhx3^Sci Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
MP:0001314	corneal opacity	"complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ercc2^tm3Jhjh/Ercc2^tm3Jhjh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Ercc2^tm3Jhjh/Ercc2^tm3Jhjh,Xpa^tm1Hvs/Xpa^tm1Hvs Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh},Xpa^tm1Hvs/Xpa^tm1Hvs Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001417	decreased exploration in new environment	"less amount of time spent investigating a new location" [J:79870]	Show Allelic Composition: Ercc2^tm3Jhjh/Ercc2^tm3Jhjh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
MP:0001513	limb grasping	"mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Ercc2^tm3Jhjh/Ercc2^tm3Jhjh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
MP:0001525	impaired balance	"reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]	Show Allelic Composition: Ercc2^tm3Jhjh/Ercc2^tm3Jhjh,Xpa^tm1Hvs/Xpa^tm1Hvs Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^tm2Jmch Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001588	hemoglobin abnormalities	"defects in the levels or the function of the oxygen-carrying protein of erythrocytes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh},Xpa^tm1Hvs/Xpa^tm1Hvs Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^tm2Jmch Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ercc2^tm3Jhjh/Ercc2^tm3Jhjh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB Allelic Composition: Ercc2^tm3Jhjh/Ercc2^tm3Jhjh,Xpa^tm1Hvs/Xpa^tm1Hvs Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh},Ercc3^tm2Jhjh/Ercc3^tm2Jhjh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001874	acanthosis	"diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ercc2^tm3Jhjh/Ercc2^tm3Jhjh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
MP:0001923	reduced female fertility	"reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Zfhx3^Sci/Zfhx3^Sci Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
MP:0001928	abnormal ovulation	"aberration in the release of an ovum from a rupturing Graafin follicle, normally regulated by a surge in lutenizing hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002007	increased sensitivity to gamma-irradiation	"increased incidence of cell death following high levels of gamma-irradiation" [J:51834]	Show Allelic Composition: Ercc3^tm2Jhjh/Ercc3^tm2Jhjh,Xpa^tm1Hvs/Xpa^tm1Hvs Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002021	increased incidence of induced tumors	"higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427]	Show Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ercc2^tm3Jhjh/Ercc2^tm3Jhjh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
MP:0002427	dwarfism	"abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002875	decreased erythrocyte count	"reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002879	increased sensitivity to X-ray irradiation	"increased incidence of cell death following high levels of X-ray irradiation" [RGD:Rat Genome Database submission]	Show Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh},Xpa^tm1Hvs/Xpa^tm1Hvs Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002938	white spotting	"the appearance of patches of white fur" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003354	astrocytosis	"a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ercc6^tm1Gvh/Ercc6^tm1Gvh,Xpa^tm1Gvh/Xpa^tm1Hvs,Tg(Pcp2-cre)2Mpin/0 Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0003786	premature aging	"earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]	Show Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh},Xpa^tm1Hvs/Xpa^tm1Hvs Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003810	abnormal hair cuticle	"anomalies in the thin, smooth and glossy outer protective cell layer of hair shaft" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv
MP:0003848	brittle hair	"hair is susceptible to breakage " [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^tm2Jmch Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003849	greasy coat	"fur is oily in appearance or texture" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004499	increased incidence of chemically-induced tumors	"higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv
MP:0004501	increased incidence of UV-induced tumors	"higher than normal frequency of tumor incidence induced by exposure to ultraviolet light" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv Allelic Composition: Ercc2^tm3Jhjh/Ercc2^tm3Jhjh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
MP:0005150	cachexia	"general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh},Xpa^tm1Hvs/Xpa^tm1Hvs Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ercc2^tm3Jhjh/Ercc2^tm3Jhjh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
MP:0005311	abnormal circulating amino acid level	"aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]	Show Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005508	abnormal skeleton morphology	"malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005621	abnormal cell physiology	"aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008058	abnormal DNA repair	"any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]	Show Allelic Composition: Ercc2^tm3Jhjh/Ercc2^tm3Jhjh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
MP:0008410	increased cellular sensitivity to ultraviolet irradiation	"greater incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh},Xpa^tm1Hvs/Xpa^tm1Hvs Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ercc2^tm3Jhjh/Ercc2^tm3Jhjh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ercc2^tm3Jhjh/Ercc2^tm3Jhjh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh},Ercc3^tm2Jhjh/Ercc3^tm2Jhjh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd
MP:0008411	decreased cellular sensitivity to ultraviolet irradiation	"reduced incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ercc2^tm1Jmch/Ercc2^tm1Jmch Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^tm2Jmch Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008412	increased cellular sensitivity to oxidative stress	"greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh},Xpa^tm1Hvs/Xpa^tm1Hvs Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh},Ercc3^tm2Jhjh/Ercc3^tm2Jhjh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008918	microgliosis	"a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ercc6^tm1Gvh/Ercc6^tm1Gvh,Xpa^tm1Gvh/Xpa^tm1Hvs,Tg(Pcp2-cre)2Mpin/0 Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0009115	abnormal fat cell morphology	"any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]	Show Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv
MP:0010179	rough coat	"coat does not have the usual smooth appearance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zfhx3^Sci/Zfhx3^Sci Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
MP:0010202	focal dorsal hair loss	"focal hair loss on the dorsal area of a rodent resulting in dorsal skin visible in a patch where hair loss occurs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:Sanger_Karp "Submission from Natasha Karp"]	Show Allelic Composition: Ercc2^tm1Jmch/Ercc2^tm1Jmch Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^tm2Jmch Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010254	nuclear cataracts	"a lens opacity located in the dense, central part of the lens" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]	Show Allelic Composition: Zfhx3^Sci/Zfhx3^Sci Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
MP:0010300	increased skin tumor incidence	"greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv
MP:0010308	decreased tumor latency	"earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ercc2^tm3Jhjh/Ercc2^tm3Jhjh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh},Xpa^tm1Hvs/Xpa^tm1Hvs Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ercc2^tm3Jhjh/Ercc2^tm3Jhjh,Xpa^tm1Hvs/Xpa^tm1Hvs Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh},Ercc3^tm2Jhjh/Ercc3^tm2Jhjh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh},Xpa^tm1Hvs/Xpa^tm1Hvs Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011094	complete embryonic lethality before implantation	"death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv Allelic Composition: Ercc2^tm1Jmch/Ercc2^tm1Jmch Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ercc2^tm2Jmch/Ercc2^tm2Jmch Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011697	vacuolated lens	"fluid filled cavities are present in the cytoplasm of the transparent structure of the eye responsible for focusing light" [MGI:llw2]	Show Allelic Composition: Zfhx3^Sci/Zfhx3^Sci Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
MP:0012734	abnormal response to radiation	"any anomaly in the physiological changes induced by ionizing radiation such as UV light, X-rays, or gamma rays" [MPD:Molly]	Show Allelic Composition: Zfhx3^Sci/Zfhx3^Sci Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr

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