MP:0000160 | kyphosis | "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Pfn1tm1Foxp/Pfn1tm1Foxp,Tg(Cdh5-cre/ERT2)1Rha/0 Genetic Background: involves: C57BL/6NTac
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MP:0000745 | tremors | "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Pfn1tm1Foxp/Pfn1tm1Foxp,Tg(Cdh5-cre/ERT2)1Rha/0 Genetic Background: involves: C57BL/6NTac
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MP:0000937 | abnormal motor neuron morphology | "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159] |
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Allelic Composition: Pfn1tm1Foxp/Pfn1tm1Foxp,Tg(Cdh5-cre/ERT2)1Rha/0 Genetic Background: involves: C57BL/6NTac
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MP:0000938 | motor neuron degeneration | "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pfn1tm1Foxp/Pfn1tm1Foxp,Tg(Cdh5-cre/ERT2)1Rha/0 Genetic Background: involves: C57BL/6NTac
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MP:0000939 | reduced motor neuron number | "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159] |
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Allelic Composition: Pfn1tm1Foxp/Pfn1tm1Foxp,Tg(Cdh5-cre/ERT2)1Rha/0 Genetic Background: involves: C57BL/6NTac
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Pfn1tm1Foxp/Pfn1tm1Foxp,Tg(Cdh5-cre/ERT2)1Rha/0 Genetic Background: involves: C57BL/6NTac
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MP:0001405 | impaired coordination | "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Pfn1tm1Foxp/Pfn1tm1Foxp,Tg(Cdh5-cre/ERT2)1Rha/0 Genetic Background: involves: C57BL/6NTac
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MP:0001513 | limb grasping | "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Pfn1tm1Foxp/Pfn1tm1Foxp,Tg(Cdh5-cre/ERT2)1Rha/0 Genetic Background: involves: C57BL/6NTac
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MP:0001728 | failure of implantation | "inability of the blastocyst to attach to the endometrium of the uterus" [J:38772] |
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Allelic Composition: Nhlh1tm1Thbr/Nhlh1tm1Thbr,Nhlh2tm1Thbr/Nhlh2tm1Thbr Genetic Background: involves: 129S4/SvJae
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MP:0001730 | embryonic growth arrest | "the cessation of development beyond a particular stage" [J:17509] |
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Allelic Composition: Nhlh1tm1Thbr/Nhlh1tm1Thbr,Nhlh2tm1Thbr/Nhlh2tm1Thbr Genetic Background: involves: 129S4/SvJae
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MP:0003354 | astrocytosis | "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Pfn1tm1Foxp/Pfn1tm1Foxp,Tg(Cdh5-cre/ERT2)1Rha/0 Genetic Background: involves: C57BL/6NTac
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MP:0008918 | microgliosis | "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pfn1tm1Foxp/Pfn1tm1Foxp,Tg(Cdh5-cre/ERT2)1Rha/0 Genetic Background: involves: C57BL/6NTac
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MP:0010053 | decreased grip strength | "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"] |
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Allelic Composition: Pfn1tm1Foxp/Pfn1tm1Foxp,Tg(Cdh5-cre/ERT2)1Rha/0 Genetic Background: involves: C57BL/6NTac
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MP:0011094 | complete embryonic lethality before implantation | "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith] |
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Allelic Composition: Nhlh1tm1Thbr/Nhlh1tm1Thbr,Nhlh2tm1Thbr/Nhlh2tm1Thbr Genetic Background: involves: 129S4/SvJae
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