ENSMUSG00000030652


Mus musculus

Features
Gene ID: ENSMUSG00000030652
  
Biological name :Coq7
  
Synonyms : 5-demethoxyubiquinone hydroxylase, mitochondrial / Coq7 / P97478
  
Possible biological names infered from orthology : coenzyme Q7, hydroxylase / Q99807
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F1
Gene start: 118509659
Gene end: 118533356
  
Corresponding Affymetrix probe sets: 10567303 (MoGene1.0st)   1416665_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032887
Ensembl peptide - ENSMUSP00000095695
Ensembl peptide - ENSMUSP00000146797
NCBI entrez gene - 12850     See in Manteia.
MGI - MGI:107207
RefSeq - NM_001304758
RefSeq - NM_009940
RefSeq Peptide - NP_001291687
RefSeq Peptide - NP_034070
swissprot - Q3TYT1
swissprot - P97478
swissprot - A0A140LIF0
Ensembl - ENSMUSG00000030652
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 coq7ENSDARG00000062594Danio rerio
 COQ7ENSGALG00000006861Gallus gallus
 COQ7ENSG00000167186Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009078  Ferritin-like superfamily
 IPR011566  Ubiquinone biosynthesis protein Coq7
 IPR012347  Ferritin-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0001306 age-dependent response to oxidative stress IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001841 neural tube formation IMP
 biological_processGO:0006744 ubiquinone biosynthetic process IEA
 biological_processGO:0006979 response to oxidative stress IMP
 biological_processGO:0008340 determination of adult lifespan IMP
 biological_processGO:0022008 neurogenesis IMP
 biological_processGO:0022904 respiratory electron transport chain IMP
 biological_processGO:0034599 cellular response to oxidative stress IMP
 biological_processGO:0042775 mitochondrial ATP synthesis coupled electron transport IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070584 mitochondrion morphogenesis IMP
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031314 extrinsic component of mitochondrial inner membrane IEA
 molecular_functionGO:0003682 chromatin binding ISO
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ift88cbbs/Ift88tm1.1Bky
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Coq7tm1Hek/Coq7tm2Hek,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0000786 abnormal neuroepithelial layer differentiation "malformation or arrest of differentiation or patterning of the epithelial layer of the brain" [J:45302]
Show

Allelic Composition: Coq7tm1Tsh/Coq7tm1Tsh
Genetic Background: involves: C57BL/6

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Ift88cbbs/Ift88tm1.1Bky
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pou3f1tm1Rsd/Pou3f1tm1Rsd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Coq7tm1Hek/Coq7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

Allelic Composition: Coq7tm1Hek/Coq7+
Genetic Background: B6.129-Coq7tm1Hek

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Pou3f1tm1Rsd/Pou3f1tm1Rsd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Coq7tm1Tsh/Coq7tm1Tsh
Genetic Background: involves: C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cysltr1tm1Ykn/Cysltr1tm1Ykn,Cysltr2tm1Ykn/Cysltr2tm1Ykn,Oxgr1tm1(KOMP)Vlcg/Oxgr1tm1(KOMP)Vlcg
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NTac

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou3f1tm1Rsd/Pou3f1tm1Rsd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

 MP:0005058 abnormal lysosome morphology "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Coq7tm1Tsh/Coq7tm1Tsh
Genetic Background: involves: C57BL/6

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Coq7tm1Tsh/Coq7tm1Tsh
Genetic Background: involves: C57BL/6

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
Show

Allelic Composition: Cysltr1tm1Ykn/Cysltr1tm1Ykn,Cysltr2tm1Ykn/Cysltr2tm1Ykn,Oxgr1tm1(KOMP)Vlcg/Oxgr1tm1(KOMP)Vlcg
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NTac

Allelic Composition: Coq7tm1Hek/Coq7tm2Hek,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0010957 abnormal aerobic respiration "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060]
Show

Allelic Composition: Coq7tm1Tsh/Coq7tm1Tsh
Genetic Background: involves: C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Pou3f1tm1Rsd/Pou3f1tm1Rsd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Coq7tm1Tsh/Coq7tm1Tsh
Genetic Background: involves: C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Coq7tm1Hek/Coq7tm2Hek,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0012556 increased cell death "increased occurrence of the cessation of function at the cellular level" [http://orcid.org/0000-0001-5208-3432]
Show

Allelic Composition: Cysltr1tm1Ykn/Cysltr1tm1Ykn,Cysltr2tm1Ykn/Cysltr2tm1Ykn,Oxgr1tm1(KOMP)Vlcg/Oxgr1tm1(KOMP)Vlcg
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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