ENSMUSG00000030763


Mus musculus

Features
Gene ID: ENSMUSG00000030763
  
Biological name :Lcmt1
  
Synonyms : Lcmt1 / leucine carboxyl methyltransferase 1
  
Possible biological names infered from orthology : Q9UIC8
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 123369784
Gene end: 123430358
  
Corresponding Affymetrix probe sets: 10557285 (MoGene1.0st)   1417044_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033025
Ensembl peptide - ENSMUSP00000146184
Ensembl peptide - ENSMUSP00000145539
NCBI entrez gene - 30949     See in Manteia.
MGI - MGI:1353593
RefSeq - NM_025304
RefSeq Peptide - NP_079580
swissprot - A2RTH5
swissprot - A0A0U1RPZ5
swissprot - A0A0U1RNF2
Ensembl - ENSMUSG00000030763
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lcmt1ENSDARG00000045140Danio rerio
 LCMT1ENSGALG00000005973Gallus gallus
 LCMT1ENSG00000205629Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lcmt2 / Q8BYR1 / tRNA wybutosine-synthesizing protein 4 / O60294* / leucine carboxyl methyltransferase 2*ENSMUSG0000007489033


Protein motifs (from Interpro)
Interpro ID Name
 IPR007213  Methyltransferase Ppm1/Ppm2/Tcmp
 IPR016651  Leucine carboxyl methyltransferase 1, LCMT1
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006479 protein methylation IEA
 biological_processGO:0006481 C-terminal protein methylation IEA
 biological_processGO:0010906 regulation of glucose metabolic process IMP
 biological_processGO:0031333 negative regulation of protein complex assembly IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0003880 protein C-terminal carboxyl O-methyltransferase activity IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008276 protein methyltransferase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018423 protein C-terminal leucine carboxyl O-methyltransferase activity IBA


Pathways (from Reactome)
Pathway description
Cyclin A/B1/B2 associated events during G2/M transition


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Hsp90aa1Tg(Tyr)2396BOve/Hsp90aa1Tg(Tyr)2396BOve
Genetic Background: FVB/N-Hsp90aa1Tg(Tyr)2396BOve

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc6a2tm1.1Mkh/Slc6a2+
Genetic Background: B6.129S6-Slc6a2tm1.1Mkh

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc6a2tm1.1Mkh/Slc6a2+
Genetic Background: B6.129S6-Slc6a2tm1.1Mkh

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a2tm1.1Mkh/Slc6a2+
Genetic Background: B6.129S6-Slc6a2tm1.1Mkh

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Zbtb16lu-Sfd/Zbtb16+
Genetic Background: involves: C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Slc6a2tm1.1Mkh/Slc6a2+
Genetic Background: B6.129S6-Slc6a2tm1.1Mkh

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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