ENSMUSG00000030772


Mus musculus

Features
Gene ID: ENSMUSG00000030772
  
Biological name :Dkk3
  
Synonyms : Dickkopf-related protein 3 / Dkk3 / Q9QUN9
  
Possible biological names infered from orthology : dickkopf WNT signaling pathway inhibitor 3 / Q9UBP4
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F1
Gene start: 112116017
Gene end: 112159057
  
Corresponding Affymetrix probe sets: 10567010 (MoGene1.0st)   1417312_at (Mouse Genome 430 2.0 Array)   1448669_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033036
NCBI entrez gene - 50781     See in Manteia.
MGI - MGI:1354952
RefSeq - XM_006508014
RefSeq - NM_015814
RefSeq - XM_006508013
RefSeq Peptide - NP_056629
swissprot - Q9QUN9
Ensembl - ENSMUSG00000030772
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dkk3aENSDARG00000103591Danio rerio
 dkk3bENSDARG00000070683Danio rerio
 DKK3ENSGALG00000005551Gallus gallus
 DKK3ENSG00000050165Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006796  Dickkopf, N-terminal cysteine-rich


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IEA
 biological_processGO:0032348 negative regulation of aldosterone biosynthetic process ISO
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway ISO
 biological_processGO:2000065 negative regulation of cortisol biosynthetic process ISO
 cellular_componentGO:0005576 extracellular region ISS
 cellular_componentGO:0005615 extracellular space ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Juptm1Kem/Juptm1Kem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Juptm1Kem/Juptm1Kem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Juptm1Kem/Juptm1Kem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Juptm1Kem/Juptm1Kem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002666 increased circulating aldosterone level "increased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Juptm1Kem/Juptm1Kem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dkk3tm1Cni/Dkk3tm1Cni,Kcnk3tm1Sgb/Kcnk3tm1Sgb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Juptm1Kem/Juptm1Kem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Juptm1Kem/Juptm1Kem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Juptm1Kem/Juptm1Kem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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