ENSMUSG00000030850


Mus musculus

Features
Gene ID: ENSMUSG00000030850
  
Biological name :Ate1
  
Synonyms : Arginyl-tRNA--protein transferase 1 / Ate1 / Q9Z2A5
  
Possible biological names infered from orthology : arginyltransferase 1 / O95260
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F3
Gene start: 130391493
Gene end: 130520369
  
Corresponding Affymetrix probe sets: 10568464 (MoGene1.0st)   1420036_at (Mouse Genome 430 2.0 Array)   1420651_at (Mouse Genome 430 2.0 Array)   1420652_at (Mouse Genome 430 2.0 Array)   1435173_at (Mouse Genome 430 2.0 Array)   1449709_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147132
Ensembl peptide - ENSMUSP00000136956
Ensembl peptide - ENSMUSP00000147239
Ensembl peptide - ENSMUSP00000148888
Ensembl peptide - ENSMUSP00000033139
Ensembl peptide - ENSMUSP00000043365
Ensembl peptide - ENSMUSP00000091556
NCBI entrez gene - 11907     See in Manteia.
MGI - MGI:1333870
RefSeq - XM_011241659
RefSeq - NM_001029895
RefSeq - NM_001136054
RefSeq - NM_001271343
RefSeq - NM_013799
RefSeq - XM_006507264
RefSeq - XM_006507265
RefSeq Peptide - NP_001258272
RefSeq Peptide - NP_038827
RefSeq Peptide - NP_001025066
RefSeq Peptide - NP_001129526
swissprot - Q4FCQ7
swissprot - Q80YP1
swissprot - A0A140LJ98
swissprot - Q9Z2A5
swissprot - A0A1L1SQ41
swissprot - J3QNU1
swissprot - A0A140LJJ7
Ensembl - ENSMUSG00000030850
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01078449.1ENSDARG00000103813Danio rerio
 ATE1ENSGALG00000009502Gallus gallus
 ATE1ENSG00000107669Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007471  N-end aminoacyl transferase, N-terminal
 IPR007472  N-end rule aminoacyl transferase, C-terminal
 IPR016181  Acyl-CoA N-acyltransferase
 IPR017137  Arginine-tRNA-protein transferase 1, eukaryotic
 IPR030700  N-end rule aminoacyl transferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010498 proteasomal protein catabolic process IEA
 biological_processGO:0016598 protein arginylation IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004057 arginyltransferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Ate1tm1Akas/Ate1tm1Akas
Genetic Background: Not Specified

 MP:0000364 abnormal vascular regression "premature regression or persistence of vessels programmed to regress and/or loss of vessels not programmed to regress" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0001443 poor grooming "below average standard of cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [MGI:CLS, J:30404]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001666 abnormal nutrient absorption "anomalous ability of the body to take in constituents of food necessary for normal physiologic function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Ate1tm1Akas/Ate1tm1Akas
Genetic Background: Not Specified

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Ate1tm1Akas/Ate1tm1Akas
Genetic Background: Not Specified

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: HrN/Hrhr
Genetic Background: involves: ORNL:STOCK Aw/a Oca2p

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl
Genetic Background: B6.129X1-Sncatm1Rosl

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: HrN/Hrhr
Genetic Background: involves: ORNL:STOCK Aw/a Oca2p

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0002176 high brain weight "greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ate1tm1Akas/Ate1tm1Akas
Genetic Background: Not Specified

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0003105 abnormal heart atrium morphology "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Ate1tm1Akas/Ate1tm1Akas
Genetic Background: Not Specified

 MP:0003830 abnormal testis development "abnormal morphogenesis of the male reproductive gland containing the germ cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100020]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ate1tm1Akas/Ate1tm1Akas
Genetic Background: Not Specified

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ate1tm1Akas/Ate1tm1Akas
Genetic Background: Not Specified

 MP:0005238 increased brain size "larger than the normal physical proportions of the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57958]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0005670 abnormal white fat physiology "functional aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0006267 abnormal intercalated disc morphology "any structural abnormality in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:64280]
Show

Allelic Composition: Ate1tm1Akas/Ate1tm1Akas
Genetic Background: Not Specified

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ate1tm1Avar/Ate1+
Genetic Background: involves: 129S1/Sv

 MP:0008853 decreased abdominal adipose tissue amount "reduction in amount of adipose tissue associated with internal organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0008965 increased basal metabolism "increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0009136 decreased brown fat cell size "reduction in the size of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322]
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Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0010502 ventricle myocardium hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the ventricular part of the heart myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011014 decreased core body temperature "reduced degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ate1tm1Akas/Ate1tm1Akas
Genetic Background: Not Specified

 MP:0011854 cerebral edema "excess accumulation of water in the intra- and/or extracellular spaces of the brain" [MGI:anna]
Show

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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