ENSMUSG00000030905


Mus musculus

Features
Gene ID: ENSMUSG00000030905
  
Biological name :Crym
  
Synonyms : Crym / Ketimine reductase mu-crystallin / O54983
  
Possible biological names infered from orthology : crystallin mu / Q14894
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F2
Gene start: 120186380
Gene end: 120202111
  
Corresponding Affymetrix probe sets: 10567546 (MoGene1.0st)   1416776_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033198
NCBI entrez gene - 12971     See in Manteia.
MGI - MGI:102675
RefSeq - NM_016669
RefSeq Peptide - NP_057878
swissprot - O54983
swissprot - Q3UPX0
Ensembl - ENSMUSG00000030905
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 crymENSDARG00000062817Danio rerio
 CRYMENSGALG00000002484Gallus gallus
 CRYMENSG00000103316Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003462  Ornithine cyclodeaminase/mu-crystallin
 IPR023401  Ornithine cyclodeaminase, N-terminal
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0042403 thyroid hormone metabolic process IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070327 thyroid hormone transport IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor IBA
 molecular_functionGO:0042562 hormone binding IMP
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0047127 thiomorpholine-carboxylate dehydrogenase activity IEA
 molecular_functionGO:0050661 NADP binding IEA
 molecular_functionGO:0070324 thyroid hormone binding IEA


Pathways (from Reactome)
Pathway description
Lysine catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005472 abnormal triiodothyronine level "aberrant concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Eloatm1Aso/Eloatm1Aso,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Eloatm1Aso/Eloatm1Aso,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0005479 decreased circulating triiodothyronine level "less than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Eloatm1Aso/Eloatm1Aso,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Atp13a2tm1.2Wtd/Atp13a2tm1.2Wtd,Tg(Prnp-SNCA*A53T)83Vle/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
Show

Allelic Composition: Atp13a2tm1.2Wtd/Atp13a2tm1.2Wtd,Tg(Prnp-SNCA*A53T)83Vle/0
Genetic Background: involves: 129 * C3H * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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