Manteia - Molecule gene

ENSMUSG00000030963

Mus musculus

Features

Gene ID:	ENSMUSG00000030963

Biological name :	Umod

Synonyms :	Q91X17 / Umod / uromodulin

Possible biological names infered from orthology :	P07911

Species:	Mus musculus

Chr. number:	7
Strand:	-1
Band:	F2
Gene start:	119462711
Gene end:	119479282

Corresponding Affymetrix probe sets:	10567380 (MoGene1.0st) 1426252_a_at (Mouse Genome 430 2.0 Array) 1456306_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000146628 Ensembl peptide - ENSMUSP00000147128 Ensembl peptide - ENSMUSP00000147039 Ensembl peptide - ENSMUSP00000146652 Ensembl peptide - ENSMUSP00000033263 NCBI entrez gene - 22242 See in Manteia. MGI - MGI:102674 RefSeq - NM_009470 RefSeq - NM_001278605 RefSeq Peptide - NP_001265534 RefSeq Peptide - NP_033496 swissprot - Q91X17 swissprot - A0A140LJ15 swissprot - A0A140LI10 swissprot - A0A140LJ95 Ensembl - ENSMUSG00000030963

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
si:ch211-226h7.3	ENSDARG00000109626	Danio rerio
si:ch211-226h7.5	ENSDARG00000074150	Danio rerio
si:ch211-226h7.6	ENSDARG00000076196	Danio rerio
si:ch211-226h7.8	ENSDARG00000095409	Danio rerio
si:ch73-180n10.1	ENSDARG00000088794	Danio rerio
si:ch73-181m17.1	ENSDARG00000097080	Danio rerio
si:ch73-338o16.4	ENSDARG00000115257	Danio rerio
si:ch73-338o16.4	ENSDARG00000092778	Danio rerio
si:dkey-239b22.2	ENSDARG00000097826	Danio rerio
si:dkey-9l20.3	ENSDARG00000105341	Danio rerio
umod	ENSDARG00000086117	Danio rerio
zgc:153932	ENSDARG00000052779	Danio rerio
zgc:153932	ENSDARG00000113315	Danio rerio
UMOD	ENSG00000169344	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Gp2 / glycoprotein 2 (zymogen granule membrane) / P55259* / glycoprotein 2*	ENSMUSG00000030954	40
Q5DID3 / Umodl1 / uromodulin-like 1 / Q5DID0*	ENSMUSG00000054134	25
Oit3 / Q8R4V5 / Oncoprotein-induced transcript 3 protein / Q8WWZ8* / oncoprotein induced transcript 3*	ENSMUSG00000009654	21

Protein motifs (from Interpro)

Interpro ID	Name
IPR000152	EGF-type aspartate/asparagine hydroxylation site
IPR000742	EGF-like domain
IPR001507	Zona pellucida domain
IPR001881	EGF-like calcium-binding domain
IPR009030	Growth factor receptor cysteine-rich domain superfamily
IPR013032	EGF-like, conserved site
IPR017977	Zona pellucida domain, conserved site
IPR018097	EGF-like calcium-binding, conserved site
IPR024731	EGF domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IEA
biological_process	GO:0007159	leukocyte cell-cell adhesion	IEA
biological_process	GO:0007588	excretion	IMP
biological_process	GO:0048878	chemical homeostasis	IMP
biological_process	GO:0072218	metanephric ascending thin limb development	IEP
biological_process	GO:0072221	metanephric distal convoluted tubule development	IEP
biological_process	GO:0072233	metanephric thick ascending limb development	IEP
biological_process	GO:1990266	neutrophil migration	IEA
cellular_component	GO:0000922	spindle pole	IEA
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0005929	cilium	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016323	basolateral plasma membrane	ISS
cellular_component	GO:0016324	apical plasma membrane	IEA
cellular_component	GO:0031225	anchored component of membrane	ISO
cellular_component	GO:0042995	cell projection	IEA
cellular_component	GO:0060170	ciliary membrane	IEA
molecular_function	GO:0005509	calcium ion binding	IEA
molecular_function	GO:0019864	IgG binding	IEA

Pathways (from Reactome)

Pathway description

Asparagine N-linked glycosylation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Umod^urehr4/Umod^urehr4 Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^urehr4/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0000194	hypercalcemia	"abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Umod^urehr4/Umod^urehr4 Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0000198	hypophosphatemia	"abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0000519	hydronephrosis	"dilation of the pelvis and calices of one or both kidneys" [J:56641]	Show Allelic Composition: Spp1^tm1Blh/Spp1^tm1Blh Genetic Background: 129S/SvEv-Spp1^tm1Blh Allelic Composition: Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: B6.129S6-Umod^tm1Xrw Allelic Composition: Umod^tm1Xrw/Umod⁺ Genetic Background: B6.129S6-Umod^tm1Xrw Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Eya1^tm1Rilm/Eya1⁺,Sumo1^{Gt(RRQ016)Byg}/Sumo1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Umod^urehr4/Umod^urehr4 Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^urehr4/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ Allelic Composition: Umod^Urehd1/Umod^Urehd1 Genetic Background: involves: C3HeB/FeJ
MP:0001762	polyuria	"increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Gdf7^tm1Tmj/Gdf7^tm1Tmj Genetic Background: involves: 129/Sv Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^Urehd1 Allelic Composition: Umod^urehr4/Umod^urehr4 Genetic Background: C3HeB/FeJ-Umod^urehr4
MP:0002412	increased susceptibility to bacterial infection	"greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Adgrv1^tm1Msat/Adgrv1^tm1Msat Genetic Background: B6.129P2-Adgrv1^tm1Msat
MP:0002644	decreased circulating triglyceride level	"lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Umod^urehr4/Umod^urehr4 Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^urehr4/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0002829	abnormal juxtaglomerular apparatus	"anomalous structure or development of the complex of modified smooth muscle cells consisting of juxtaglomerular cells, extraglomerular mesangium lacis cells, the macula densa of the distal convoluted tubule, and granular epithelial peripolar cells; these cells are found in the walls of afferent and efferent glomerular arterioles" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gdf7^tm1Tmj/Gdf7^tm1Tmj Genetic Background: involves: 129/Sv
MP:0002901	hyperphosphaturia	"an increase of excretion of phosphates in the urine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Spp1^tm1Blh/Spp1^tm1Blh Genetic Background: 129S/SvEv-Spp1^tm1Blh Allelic Composition: Spp1^tm1Blh/Spp1^tm1Blh,Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: 129S/SvEv-Spp1^tm1Blh Umod^tm1Xrw
MP:0002968	increased circulating alkaline phosphatase level	"elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0002987	abnormal urine osmolarity	"changes in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]	Show Allelic Composition: Gdf7^tm1Tmj/Gdf7^tm1Tmj Genetic Background: involves: 129/Sv
MP:0002988	decreased urine osmolarity	"reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]	Show Allelic Composition: Umod^urehr4/Umod^urehr4 Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0003197	kidney calcification	"pathologic deposition of calcium salts in the kidney" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: 129S/SvEv-Umod^tm1Xrw Allelic Composition: Spp1^tm1Blh/Spp1^tm1Blh,Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: 129S/SvEv-Spp1^tm1Blh Umod^tm1Xrw Allelic Composition: Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: B6.129S6-Umod^tm1Xrw Allelic Composition: Umod^tm1Xrw/Umod⁺ Genetic Background: B6.129S6-Umod^tm1Xrw
MP:0003215	renal interstitial fibrosis	"formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]	Show Allelic Composition: Umod^urehr4/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ Allelic Composition: Umod^Urehd1/Umod^Urehd1 Genetic Background: involves: C3HeB/FeJ
MP:0003670	dilated glomerular capsule	"an expansion in volume of the expanded beginning of a nephron that contains the glomerulus" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:91499]	Show Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0003795	abnormal bone structure		Show Allelic Composition: Umod^urehr4/Umod^urehr4 Genetic Background: C3HeB/FeJ-Umod^urehr4
MP:0003949	abnormal circulating lipid level	"anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Umod^urehr4/Umod^urehr4 Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^urehr4/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^urehr4
MP:0003960	increased lean body mass	"more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Umod^urehr4/Umod^urehr4 Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^urehr4/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^urehr4
MP:0003985	renal fibrosis	"formation of fibrous tissue in the kidney as a result of repair or a reactive process" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: 129S/SvEv-Umod^tm1Xrw Allelic Composition: Spp1^tm1Blh/Spp1^tm1Blh,Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: 129S/SvEv-Spp1^tm1Blh Umod^tm1Xrw
MP:0004151	hypoferremia	"less than the normal concentration of this metallic element in the blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0004154	renal tubular necrosis	"pathological cell death in the proximal and/or distal renal tubules, usually due to irreversible damage " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Umod^urehr4/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ Allelic Composition: Umod^Urehd1/Umod^Urehd1 Genetic Background: involves: C3HeB/FeJ
MP:0004193	abnormal kidney papilla morphology	"any structural anomaly of the apex of the renal pyramid that projects into a calyx" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: 129S/SvEv-Umod^tm1Xrw Allelic Composition: Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: B6.129S6-Umod^tm1Xrw
MP:0004860	dilated kidney collecting duct	"stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: 129S/SvEv-Umod^tm1Xrw Allelic Composition: Spp1^tm1Blh/Spp1^tm1Blh,Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: 129S/SvEv-Spp1^tm1Blh Umod^tm1Xrw Allelic Composition: Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: B6.129S6-Umod^tm1Xrw
MP:0005179	decreased total circulating cholesterol level	"less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Umod^urehr4/Umod^urehr4 Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^urehr4/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0005360	urolithiasis	"presence of calculi in any part of the urinary system" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:85461, J:85462]	Show Allelic Composition: Spp1^tm1Blh/Spp1^tm1Blh Genetic Background: 129S/SvEv-Spp1^tm1Blh Allelic Composition: Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: B6.129S6-Umod^tm1Xrw Allelic Composition: Umod^tm1Xrw/Umod⁺ Genetic Background: B6.129S6-Umod^tm1Xrw
MP:0005441	hypercalciuria	"excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949]	Show Allelic Composition: Spp1^tm1Blh/Spp1^tm1Blh Genetic Background: 129S/SvEv-Spp1^tm1Blh Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0005459	decreased percent body fat	"less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Umod^urehr4/Umod^urehr4 Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^urehr4/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^urehr4
MP:0005528	decreased glomerular filtration rate	"less than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gdf7^tm1Tmj/Gdf7^tm1Tmj Genetic Background: involves: 129/Sv Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^Urehd1 Allelic Composition: Umod^Urehd1/Umod^Urehd1 Genetic Background: involves: C3HeB/FeJ
MP:0005534	decreased body temperature	"less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Umod^urehr4/Umod^urehr4 Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^urehr4/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^urehr4
MP:0005553	increased circulating creatinine level	"greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^Urehd1 Allelic Composition: Umod^urehr4/Umod^urehr4 Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^urehr4/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0005558	decreased creatinine clearance	"less than the normal amount of this creatine metabolite filtered by the kidneys in a specific period of time; indicative of kidney function" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Gdf7^tm1Tmj/Gdf7^tm1Tmj Genetic Background: involves: 129/Sv
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^Urehd1
MP:0005565	increased blood urea nitrogen level	"high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^Urehd1 Allelic Composition: Umod^urehr4/Umod^urehr4 Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^urehr4/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ Allelic Composition: Umod^Urehd1/Umod^Urehd1 Genetic Background: involves: C3HeB/FeJ
MP:0005619	increased potassium excretion	"greater than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^Urehd1 Allelic Composition: Umod^urehr4/Umod^urehr4 Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: 129S/SvEv-Umod^tm1Xrw Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0005627	increased circulating potassium level	"greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]	Show Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0006272	abnormal renal organic anion excretion	"anomaly in the ability of the kidneys to elimiate organic acids (represented by the prototypical substrate para-aminohippurate (PAH))" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:108655]	Show Allelic Composition: Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: 129S/SvEv-Umod^tm1Xrw
MP:0006316	increased urine sodium level	"higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Umod^urehr4/Umod^urehr4 Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: 129S/SvEv-Umod^tm1Xrw Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0006317	decreased urine sodium level	"lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^Urehd1 Allelic Composition: Umod^urehr4/Umod^urehr4 Genetic Background: C3HeB/FeJ-Umod^urehr4
MP:0008821	increased blood uric acid level	"greater concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MESH:D03.132.960.877, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Umod^urehr4/Umod^urehr4 Genetic Background: C3HeB/FeJ-Umod^urehr4
MP:0009350	decreased urine pH	"increased urine acidity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: 129S/SvEv-Umod^tm1Xrw
MP:0009378	abnormal endoplasmic reticulum morphology	"any structural anomaly of irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells" [GO:0005783]	Show Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0009642	abnormal blood homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Umod^urehr4/Umod^urehr4 Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^urehr4/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^urehr4
MP:0009643	abnormal urine homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Umod^urehr4/Umod^urehr4 Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: 129S/SvEv-Umod^tm1Xrw
MP:0009644	uremia	"an excess of urea, creatinine, and other nitrogenous end products of protein and amino acid metabolism in the blood; usually indicative of kidney dysfunction" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Umod^urehr4/Umod^urehr4 Genetic Background: C3HeB/FeJ-Umod^urehr4
MP:0009645	crystalluria	"excretion of crystalline material in the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: 129S/SvEv-Umod^tm1Xrw Allelic Composition: Spp1^tm1Blh/Spp1^tm1Blh,Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: 129S/SvEv-Spp1^tm1Blh Umod^tm1Xrw
MP:0009810	increased urine uric acid level	"greater concentration in the urine of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: 129S/SvEv-Umod^tm1Xrw Allelic Composition: Spp1^tm1Blh/Spp1^tm1Blh,Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: 129S/SvEv-Spp1^tm1Blh Umod^tm1Xrw
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^Urehd1 Allelic Composition: Umod^urehr4/Umod^urehr4 Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^urehr4/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0010124	decreased bone mineral content	"reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Umod^urehr4/Umod^urehr4 Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^urehr4/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0011331	abnormal papillary duct morphology	"any structural anomaly of the largest straight excretory ducts in the kidney medulla and papillae that are a continuation of the collecting tubules, and that open into the area cribosa" [ISBN:0-683-40008-8]	Show Allelic Composition: Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: 129S/SvEv-Umod^tm1Xrw Allelic Composition: Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: B6.129S6-Umod^tm1Xrw
MP:0011344	abnormal loop of Henle ascending limb thick segment morphology	"any structural anomaly of the distal sub-portion of the ascending loop of Henle which is lined by simple cuboidal epithelium and enters the renal cortex to empty a hypotonic filtrate into the distal convoluted tubule" [MGI:anna]	Show Allelic Composition: Gdf7^tm1Tmj/Gdf7^tm1Tmj Genetic Background: involves: 129/Sv Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0011424	decreased urine uric acid level	"abnormally low amount in the urine of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MGI:anna]	Show Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0011431	increased urine flow rate	"increased volume of urine produced in a specified period of time" [MGI:anna]	Show Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0011432	decreased urine flow rate	"reduced volume of urine produced in a specified period of time" [MGI:anna]	Show Allelic Composition: Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: 129S/SvEv-Umod^tm1Xrw
MP:0011435	increased urine magnesium level	"higher than normal amount of magnesium in the urine" [MGI:anna]	Show Allelic Composition: Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: 129S/SvEv-Umod^tm1Xrw Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0011459	increased urine chloride ion level	"abnormally large amounts of chloride ion in the urine" [MGI:csmith]	Show Allelic Composition: Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: 129S/SvEv-Umod^tm1Xrw Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0011465	abnormal urine urea nitrogen level	"any change in the amount of nitrogen in the form of urea in the urine" [MGI:csmith]	Show Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0011470	increased urine creatinine level	"an increased amount of creatinine in the urine compared to the normal state" [MGI:csmith]	Show Allelic Composition: Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: 129S/SvEv-Umod^tm1Xrw
MP:0011471	decreased urine creatinine level	"a reduced amount of creatinine in the urine compared to the normal state" [MGI:csmith]	Show Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^Urehd1
MP:0011682	renal glomerulus cysts	"abnormal membranous sacs in any portion of the renal glomerulus" [MGI:csmith]	Show Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0011735	increased urine ammonia level	"a greater amount of ammonia in the urine compared to the normal state" [MGI:anna]	Show Allelic Composition: Umod^tm1Xrw/Umod^tm1Xrw Genetic Background: 129S/SvEv-Umod^tm1Xrw
MP:0011891	decreased circulating ferritin level	"reduced concentration in the blood of ferritin, a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion; some ferritin is also found in the blood and is measured in tests for overall iron levels, anemia and chronic diseases" [MGI:csmith]	Show Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0011894	decreased circulating transferrin level	"reduced concentration in the blood of a plasma protein that reversibly binds and transports iron and other metal ions through the blood to the liver, spleen and bone marrow" [MGI:csmith]	Show Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: involves: C3HeB/FeJ
MP:0011939	increased food intake	"increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^Urehd1
MP:0011941	increased fluid intake	"increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Umod^Urehd1/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^Urehd1
MP:0020234	decreased basal metabolism	"decrease in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [GOC:NV]	Show Allelic Composition: Umod^urehr4/Umod^urehr4 Genetic Background: C3HeB/FeJ-Umod^urehr4 Allelic Composition: Umod^urehr4/Umod⁺ Genetic Background: C3HeB/FeJ-Umod^urehr4

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000013418	Q09199 / B4galnt2 / Beta-1,4 N-acetylgalactosaminyltransferase 2 / Q8NHY0* / beta-1,4-N-acetyl-galactosaminyltransferase 2*	/ reaction

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