ENSMUSG00000031146


Mus musculus

Features
Gene ID: ENSMUSG00000031146
  
Biological name :Plp2
  
Synonyms : Plp2 / Proteolipid protein 2 / Q9R1Q7
  
Possible biological names infered from orthology : Q04941
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A1.1
Gene start: 7667941
Gene end: 7671390
  
Corresponding Affymetrix probe sets: 10411359 (MoGene1.0st)   10473022 (MoGene1.0st)   10603346 (MoGene1.0st)   1453572_a_at (Mouse Genome 430 2.0 Array)   1456247_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033486
NCBI entrez gene - 18824     See in Manteia.
MGI - MGI:1298382
RefSeq - NM_019755
RefSeq Peptide - NP_062729
swissprot - Q0VEW4
swissprot - Q9R1Q7
Ensembl - ENSMUSG00000031146
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plp2ENSDARG00000036630Danio rerio
 PLP2ENSG00000102007Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm6169 / Q9R1Q7 / predicted gene 6169 / PLP2* / Q04941* / proteolipid protein 2*ENSMUSG00000057762100
Cmtm3 / Q99LJ5 / CKLF-like MARVEL transmembrane domain-containing protein 3 / Q96MX0* / CKLF like MARVEL transmembrane domain containing 3*ENSMUSG0000003187524
Cmtm5 / Q9D6G9 / CKLF-like MARVEL transmembrane domain-containing protein 5 / Q96DZ9* / CKLF like MARVEL transmembrane domain containing 5*ENSMUSG0000004075924


Protein motifs (from Interpro)
Interpro ID Name
 IPR008253  Marvel domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005789 endoplasmic reticulum membrane IBA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 molecular_functionGO:0019956 chemokine binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003076 increased susceptibility to ischemic brain injury "increased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [J:90111, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0008546 abnormal vesicle-mediated transport "anomaly in the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell" [GO:0016192]
Show

Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0009378 abnormal endoplasmic reticulum morphology "any structural anomaly of irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells" [GO:0005783]
Show

Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0020354 increased endoplasmic reticulum stress "increase in in the accumulation of misfolded or unfolded proteins in the endoplasmic reticulum lumen; this accumulation may be stimulated by genetic or enviromental factors" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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