ENSMUSG00000031354


Mus musculus

Features
Gene ID: ENSMUSG00000031354
  
Biological name :Amelx
  
Synonyms : Amelogenin, X isoform / Amelx / P63277
  
Possible biological names infered from orthology : amelogenin, X-linked / amelogenin, Y-linked / AMELY / Q99217 / Q99218
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: F5
Gene start: 169176114
Gene end: 169187200
  
Corresponding Affymetrix probe sets: 10607924 (MoGene1.0st)   1451614_a_at (Mouse Genome 430 2.0 Array)   1451686_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000065966
Ensembl peptide - ENSMUSP00000107746
Ensembl peptide - ENSMUSP00000107747
Ensembl peptide - ENSMUSP00000107748
NCBI entrez gene - 11704     See in Manteia.
MGI - MGI:88005
RefSeq - XM_017318358
RefSeq - NM_001081978
RefSeq - NM_001290371
RefSeq - NM_009666
RefSeq - XM_017318356
RefSeq - XM_017318357
RefSeq Peptide - NP_001075447
RefSeq Peptide - NP_001277300
RefSeq Peptide - NP_033796
swissprot - P63277
swissprot - Q6PCW7
swissprot - R9W2T8
Ensembl - ENSMUSG00000031354
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AMELXENSG00000125363Homo sapiens
 AMELYENSG00000099721Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004116  Amelogenin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IMP
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0031214 biomineral tissue development IEA
 biological_processGO:0034505 tooth mineralization IMP
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0051592 response to calcium ion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005604 basement membrane IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0009986 cell surface IMP
 cellular_componentGO:0030139 endocytic vesicle IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0099080 supramolecular complex IDA
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IMP
 molecular_functionGO:0030345 structural constituent of tooth enamel IBA
 molecular_functionGO:0031402 sodium ion binding IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046848 hydroxyapatite binding IDA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: AmelxRgsc888/Amelx+
Genetic Background: involves: C57BL/6JJcl * DBA/2J

 MP:0000126 brittle teeth "fragile and likely to break teeth" [J:61509]
Show

Allelic Composition: Gpi1b-m2H/Gpi1b-m2H
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Amelxtm1Msnd/Amelxtm1Msnd
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Amelxtm1Msnd/Amelx+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Amelxtm2Msnd/Amelxtm2Msnd
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Amelxtm2Msnd/Amelx+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: AmelxRgsc888/Amelx+
Genetic Background: involves: C57BL/6JJcl * DBA/2J

Allelic Composition: AmelxRgsc888/Y
Genetic Background: involves: C57BL/6JJcl * DBA/2J

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: AmelxRgsc888/Amelx+
Genetic Background: involves: C57BL/6JJcl * DBA/2J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Ay/A
Genetic Background: involves: C3H/HeJ * C57BL/6J-Ay/a

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gpi1b-m2H/Gpi1b-m2H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002576 abnormal enamel morphology "malformation of the hard outer coating of the exposed portion of the tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:71126, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Amelxtm1Msnd/Amelxtm1Msnd
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Amelxtm2Msnd/Amelxtm2Msnd
Genetic Background: involves: 129X1/SvJ

Allelic Composition: AmelxRgsc888/Amelx+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: AmelxRgsc888/Y
Genetic Background: involves: C57BL/6JJcl * DBA/2J

Allelic Composition: AmelxRgsc888/AmelxRgsc888
Genetic Background: involves: C57BL/6JJcl * DBA/2J

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX*P70T)2Gibs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX-LRAP)9Gibs/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002577 reduced enamel thickness "thin hard coating of the exposed portion of the tooth" [J:71126, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gpi1b-m2H/Gpi1b-m2H
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Amelxtm1Msnd/Amelxtm1Msnd
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Amelxtm2Msnd/Amelxtm2Msnd
Genetic Background: involves: 129X1/SvJ

Allelic Composition: AmelxRgsc888/Amelx+
Genetic Background: involves: C57BL/6JJcl * DBA/2J

Allelic Composition: Amelxtm3Msnd/Amelxtm3Msnd
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX-LRAP)9Gibs/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002649 abnormal enamel rod pattern "anomalous orientation of the structural unit of tooth enamel " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gpi1b-m2H/Gpi1b-m2H
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Amelxtm1Msnd/Amelxtm1Msnd
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Amelxtm1Msnd/Amelx+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Amelxtm2Msnd/Amelxtm2Msnd
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Amelxtm2Msnd/Amelx+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: AmelxRgsc888/Amelx+
Genetic Background: involves: C57BL/6JJcl * DBA/2J

Allelic Composition: AmelxRgsc888/Y
Genetic Background: involves: C57BL/6JJcl * DBA/2J

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX-LRAP)9Gibs/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002650 abnormal ameloblast morphology "malformation of the epithelial cells of the inner layer of the enamel organ of the developing tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Amelxtm1Msnd/Amelxtm1Msnd
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Amelxtm2Msnd/Amelxtm2Msnd
Genetic Background: involves: 129X1/SvJ

Allelic Composition: AmelxRgsc888/Amelx+
Genetic Background: involves: C57BL/6JJcl * DBA/2J

Allelic Composition: AmelxRgsc888/Y
Genetic Background: involves: C57BL/6JJcl * DBA/2J

Allelic Composition: AmelxRgsc888/AmelxRgsc888
Genetic Background: involves: C57BL/6JJcl * DBA/2J

 MP:0002689 abnormal molar morphology "structural defect of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [il:Ira Lu , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: AmelxRgsc888/Y
Genetic Background: involves: C57BL/6JJcl * DBA/2J

 MP:0003932 abnormal molar crown morphology "defects in the upper part of the molar, which is normally covered with enamel " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Amelxtm2Msnd/Amelxtm2Msnd
Genetic Background: involves: 129X1/SvJ

 MP:0004830 short incisors "reduced length of the long pointed teeth; most anterior and prominent in the jaw" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: AmelxRgsc888/Amelx+
Genetic Background: involves: C57BL/6JJcl * DBA/2J

Allelic Composition: AmelxRgsc888/Y
Genetic Background: involves: C57BL/6JJcl * DBA/2J

 MP:0005358 abnormal incisor morphology "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
Show

Allelic Composition: AmelxRgsc888/Amelx+
Genetic Background: involves: C57BL/6JJcl * DBA/2J

Allelic Composition: AmelxRgsc888/Y
Genetic Background: involves: C57BL/6JJcl * DBA/2J

 MP:0010096 abnormal incisor color "anomaly in the color and shading of the incisor, which normally presents in shades of white" [PMID:12407097]
Show

Allelic Composition: AmelxRgsc888/Amelx+
Genetic Background: involves: C57BL/6JJcl * DBA/2J

Allelic Composition: AmelxRgsc888/Y
Genetic Background: involves: C57BL/6JJcl * DBA/2J

 MP:0030050 large mandible "increased size of the lower bony framework of the mouth where the inferior teeth are held" [MGI:anna]
Show

Allelic Composition: AmelxRgsc888/Y
Genetic Background: involves: C57BL/6JJcl * DBA/2J

 MP:0030089 short lower incisors "reduced length of the lower set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
Show

Allelic Composition: AmelxRgsc888/Amelx+
Genetic Background: involves: C57BL/6JJcl * DBA/2J

Allelic Composition: AmelxRgsc888/Y
Genetic Background: involves: C57BL/6JJcl * DBA/2J

 MP:0030090 short upper incisors "reduced length of the upper set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
Show

Allelic Composition: AmelxRgsc888/Amelx+
Genetic Background: involves: C57BL/6JJcl * DBA/2J

Allelic Composition: AmelxRgsc888/Y
Genetic Background: involves: C57BL/6JJcl * DBA/2J

 MP:0030450 abnormal enamel mineralization "anomaly in the process by which calcium salts, mainly carbonated hydroxyapatite, are deposited into the dental enamel" [GO:0070166]
Show

Allelic Composition: AmelxRgsc888/Amelx+
Genetic Background: involves: C57BL/6JJcl * DBA/2J

Allelic Composition: AmelxRgsc888/Y
Genetic Background: involves: C57BL/6JJcl * DBA/2J

 MP:0030457 abnormal molar cusp morphology "any structural anomaly of an elevation or mound on the crown of a molar tooth making up a part of the occlusal (masticatory) surface" [https://medical-dictionary.thefreedictionary.com/cusp+of+tooth, MGI:anna]
Show

Allelic Composition: Amelxtm1Msnd/Amelxtm1Msnd
Genetic Background: involves: 129X1/SvJ

Allelic Composition: AmelxRgsc888/Y
Genetic Background: involves: C57BL/6JJcl * DBA/2J

 MP:0030458 abnormal tooth wear "change in the progression or severity of loss of tooth substance, usually resulting from abrasion, attrition and erosion acting singly or concurrently; tooth wear is a normal, age-dependent physiological process that leads to surface loss of dental hard tissues" [https://www.igi-global.com/dictionary/tooth-wear/45534, https://www.slideshare.net/aneeqa_yaqub/tooth-wear-and-its-types, PMID:22240686]
Show

Allelic Composition: Amelxtm1Msnd/Amelxtm1Msnd
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Amelxtm2Msnd/Amelxtm2Msnd
Genetic Background: involves: 129X1/SvJ

Allelic Composition: AmelxRgsc888/Y
Genetic Background: involves: C57BL/6JJcl * DBA/2J

 MP:0030460 enamel pits "presence of small depressions in the dental enamel" [HP:0009722]
Show

Allelic Composition: AmelxRgsc888/Y
Genetic Background: involves: C57BL/6JJcl * DBA/2J

 MP:0030513 short Tomes process "decreased length of the pyramidal extension at the apical pole of a secretory ameloblast that plays an important role in organizing the enamel crystals into a complex network of rod (prism) and interrod enamel" [MGI:anna]
Show

Allelic Composition: Amelxtm1Msnd/Amelxtm1Msnd
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Amelxtm2Msnd/Amelxtm2Msnd
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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