ENSMUSG00000031381


Mus musculus

Features
Gene ID: ENSMUSG00000031381
  
Biological name :Piga
  
Synonyms : N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein / Piga / Q64323
  
Possible biological names infered from orthology : P37287 / phosphatidylinositol glycan anchor biosynthesis class A
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F5
Gene start: 164419787
Gene end: 164433916
  
Corresponding Affymetrix probe sets: 10603109 (MoGene1.0st)   1427305_at (Mouse Genome 430 2.0 Array)   1453497_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122176
Ensembl peptide - ENSMUSP00000147146
Ensembl peptide - ENSMUSP00000146808
Ensembl peptide - ENSMUSP00000146731
Ensembl peptide - ENSMUSP00000138077
Ensembl peptide - ENSMUSP00000137831
Ensembl peptide - ENSMUSP00000033754
Ensembl peptide - ENSMUSP00000107874
NCBI entrez gene - 18700     See in Manteia.
MGI - MGI:99461
RefSeq - XM_017318428
RefSeq - NM_011081
RefSeq - XM_006528758
RefSeq - XM_011247793
RefSeq Peptide - NP_035211
swissprot - M0QWY7
swissprot - A2AIH4
swissprot - A2AIH5
swissprot - Q64323
swissprot - A0A140LJB2
swissprot - A0A140LIG1
swissprot - M0QWH5
swissprot - A0A140LI97
Ensembl - ENSMUSG00000031381
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pigaENSDARG00000041040Danio rerio
 PIGAENSGALG00000016559Gallus gallus
 PIGAENSG00000165195Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001296  Glycosyl transferase, family 1
 IPR013234  PIGA, GPI anchor biosynthesis


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006506 GPI anchor biosynthetic process IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity IBA


Pathways (from Reactome)
Pathway description
Synthesis of glycosylphosphatidylinositol (GPI)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fbn1tm1Rmz/Fbn1tm1Rmz
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Agtr1atm1Unc/Agtr1a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Pigatm1Bsl/Y,Tg(FES-cre)31Bsl/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA/Ca

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Fbn1tm1Rmz/Fbn1tm1Rmz
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Fbn1tm1Rmz/Fbn1tm1Rmz
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001124 abnormal gametes "anomaly of any mature reproductive cell, ovum or spermatozoon, capable of fusing with a cell of similar origin, but opposite sex, to produce a zygote" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Agtr1atm1Unc/Agtr1a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pigatm1Tak/Y,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0001211 wrinkled skin "irregular folds and/or indentations on the skin" [J:19212]
Show

Allelic Composition: Pigatm1Tak/Y,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Comptm1Mbri/Comp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Pigatm1Tak/Y,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Pigatm1Bsl/Y,Tg(FES-cre)31Bsl/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA/Ca

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Pigatm1Bsl/Y,Tg(FES-cre)31Bsl/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA/Ca

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Pigatm1Bsl/Y,Tg(FES-cre)31Bsl/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA/Ca

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Fbn1tm1Rmz/Fbn1tm1Rmz
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Fbn1tm1Rmz/Fbn1tm1Rmz
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Agtr1atm1Unc/Agtr1a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Pigatm1Bsl/Y,Tg(FES-cre)31Bsl/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA/Ca

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbn1tm1Rmz/Fbn1tm1Rmz
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0002947 hemangioma "proliferation of blood vessels leading to a mass that resembles a neoplasm" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87544]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Pigatm1Bsl/Y,Tg(FES-cre)31Bsl/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA/Ca

 MP:0003656 abnormal erythrocyte physiology "functional anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0003950 abnormal plasma membrane morphology "anomalous structure of the semipermeable membrane that encloses the cytoplasm of a cell" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Aplntm1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004542 impaired acrosome reaction "abnormality in the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtr1atm1Unc/Agtr1a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pigatm1Tak/Y,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Fbn1tm1Rmz/Fbn1tm1Rmz
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Pigatm1.1Tak/Piga+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pigatm2Tak/Y
Genetic Background: chimera involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr