ENSMUSG00000031397


Mus musculus

Features
Gene ID: ENSMUSG00000031397
  
Biological name :Tktl1
  
Synonyms : Q99MX0 / Tktl1 / Transketolase-like protein 1
  
Possible biological names infered from orthology : P51854 / transketolase like 1
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A7.3
Gene start: 74177259
Gene end: 74208500
  
Corresponding Affymetrix probe sets: 10600326 (MoGene1.0st)   1420064_s_at (Mouse Genome 430 2.0 Array)   1420065_at (Mouse Genome 430 2.0 Array)   1449567_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117388
Ensembl peptide - ENSMUSP00000010127
NCBI entrez gene - 83553     See in Manteia.
MGI - MGI:1933244
RefSeq - NM_031379
RefSeq Peptide - NP_113556
swissprot - D6REV0
swissprot - Q99MX0
Ensembl - ENSMUSG00000031397
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tktbENSDARG00000006019Danio rerio
 TKTL1ENSG00000007350Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tktl2 / transketolase-like 2 / Q9H0I9*ENSMUSG0000002551970
Tkt / P40142 / Transketolase / P29401*ENSMUSG0000002195760


Protein motifs (from Interpro)
Interpro ID Name
 IPR005474  Transketolase, N-terminal
 IPR005475  Transketolase-like, pyrimidine-binding domain
 IPR009014  Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II
 IPR029061  Thiamin diphosphate-binding fold
 IPR033248  Transketolase, C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004802 transketolase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1ctm1Itl/Cacna1ctm1Itl
Genetic Background: B6.129S-Cacna1ctm1Itl

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1ctm1Itl/Cacna1ctm1Itl
Genetic Background: B6.129S-Cacna1ctm1Itl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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