ENSMUSG00000031483


Mus musculus

Features
Gene ID: ENSMUSG00000031483
  
Biological name :Erlin2
  
Synonyms : Erlin2 / Q8BFZ9
  
Possible biological names infered from orthology : ER lipid raft associated 2 / O94905
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A2
Gene start: 27023261
Gene end: 27040328
  
Corresponding Affymetrix probe sets: 10571114 (MoGene1.0st)   1435223_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033873
Ensembl peptide - ENSMUSP00000148228
Ensembl peptide - ENSMUSP00000148192
Ensembl peptide - ENSMUSP00000147897
Ensembl peptide - ENSMUSP00000147642
Ensembl peptide - ENSMUSP00000147616
Ensembl peptide - ENSMUSP00000147516
Ensembl peptide - ENSMUSP00000147310
NCBI entrez gene - 244373     See in Manteia.
MGI - MGI:2387215
RefSeq - XM_006509117
RefSeq - NM_153592
RefSeq - XM_006509114
RefSeq - XM_006509115
RefSeq - XM_006509116
RefSeq Peptide - NP_705820
swissprot - A0A1B0GT43
swissprot - A0A1B0GT70
swissprot - Q8BFZ9
swissprot - A0A1B0GSD8
swissprot - A0A1B0GRS4
swissprot - A0A1B0GRQ1
swissprot - A0A1B0GQZ0
swissprot - A0A1B0GRG7
Ensembl - ENSMUSG00000031483
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A3QK16ENSDARG00000086523Danio rerio
 erlin2ENSDARG00000095968Danio rerio
 ERLIN2ENSGALG00000003092Gallus gallus
 ERLIN2ENSG00000147475Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Erlin1 / ER lipid raft associated 1 / O75477*ENSMUSG0000002519872


Protein motifs (from Interpro)
Interpro ID Name
 IPR001107  Band 7 domain
 IPR033294  Erlin1/2
 IPR036013  Band 7/SPFH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IEA
 biological_processGO:0032933 SREBP signaling pathway IEA
 biological_processGO:0045541 negative regulation of cholesterol biosynthetic process IEA
 biological_processGO:0045717 negative regulation of fatty acid biosynthetic process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015485 cholesterol binding IBA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA


Pathways (from Reactome)
Pathway description
ABC-family proteins mediated transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0003795 abnormal bone structure 
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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