ENSMUSG00000031557


Mus musculus

Features
Gene ID: ENSMUSG00000031557
  
Biological name :Plekha2
  
Synonyms : Pleckstrin homology domain-containing family A member 2 / Plekha2 / Q9ERS5
  
Possible biological names infered from orthology : pleckstrin homology domain containing A2
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A2
Gene start: 25039144
Gene end: 25102376
  
Corresponding Affymetrix probe sets: 10577792 (MoGene1.0st)   1417288_at (Mouse Genome 430 2.0 Array)   1417289_at (Mouse Genome 430 2.0 Array)   1436177_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122564
Ensembl peptide - ENSMUSP00000066546
Ensembl peptide - ENSMUSP00000096464
Ensembl peptide - ENSMUSP00000116764
NCBI entrez gene - 83436     See in Manteia.
MGI - MGI:1928144
RefSeq - XM_006509227
RefSeq - XM_006509228
RefSeq - XM_006509230
RefSeq - NM_031257
RefSeq Peptide - NP_112547
swissprot - Q9ERS5
swissprot - D3Z3L8
swissprot - F8WIK5
Ensembl - ENSMUSG00000031557
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-204d2.4ENSDARG00000078221Danio rerio
 PLEKHA2ENSGALG00000003349Gallus gallus
 PLEKHA2ENSG00000169499Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BUL6 / Plekha1 / Pleckstrin homology domain-containing family A member 1 / Q9HB21* / pleckstrin homology domain containing A1*ENSMUSG0000004026843


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR024774  Pleckstrin homology domain, Mcp5-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001954 positive regulation of cell-matrix adhesion ISO
 biological_processGO:0032065 cortical protein anchoring IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0016020 membrane IBA
 molecular_functionGO:0001968 fibronectin binding ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0030165 PDZ domain binding IPI
 molecular_functionGO:0043236 laminin binding ISO
 molecular_functionGO:0043325 phosphatidylinositol-3,4-bisphosphate binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ

 MP:0030018 increased cardiac cell glucose uptake "increased ability of the cells of the heart to take in glucose" [MGI:anna]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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