ENSMUSG00000031730


Mus musculus

Features
Gene ID: ENSMUSG00000031730
  
Biological name :Dhodh
  
Synonyms : Dhodh / Dihydroorotate dehydrogenase (quinone), mitochondrial / O35435
  
Possible biological names infered from orthology : dihydroorotate dehydrogenase (quinone) / Q02127
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: D3
Gene start: 109591343
Gene end: 109608673
  
Corresponding Affymetrix probe sets: 10581612 (MoGene1.0st)   1417581_at (Mouse Genome 430 2.0 Array)   1417582_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115934
Ensembl peptide - ENSMUSP00000118612
Ensembl peptide - ENSMUSP00000117980
Ensembl peptide - ENSMUSP00000114190
Ensembl peptide - ENSMUSP00000115549
NCBI entrez gene - 56749     See in Manteia.
MGI - MGI:1928378
RefSeq - NM_020046
RefSeq Peptide - NP_064430
swissprot - F6ZQJ5
swissprot - E9Q1V3
swissprot - O35435
swissprot - D3YZY5
swissprot - F6TCT7
Ensembl - ENSMUSG00000031730
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dhodhENSDARG00000051889Danio rerio
 DHODHENSGALG00000000802Gallus gallus
 DHODHENSG00000102967Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001295  Dihydroorotate dehydrogenase, conserved site
 IPR005719  Dihydroorotate dehydrogenase, class 2
 IPR005720  Dihydroorotate dehydrogenase domain
 IPR012135  Dihydroorotate dehydrogenase, class 1/ 2
 IPR013785  Aldolase-type TIM barrel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006207 "de novo" pyrimidine nucleobase biosynthetic process IEA
 biological_processGO:0006221 pyrimidine nucleotide biosynthetic process IEA
 biological_processGO:0006222 UMP biosynthetic process IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007595 lactation IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0031000 response to caffeine IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042594 response to starvation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0044205 "de novo" UMP biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0090140 regulation of mitochondrial fission IEA
 biological_processGO:1903576 response to L-arginine IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004152 dihydroorotate dehydrogenase activity IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0010181 FMN binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA
 molecular_functionGO:0048039 ubiquinone binding IEA


Pathways (from Reactome)
Pathway description
Pyrimidine biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0013525 decreased KLRG1-positive CD4-positive NK T cell number "reduction in the number of KLRG1-positive CD4-positive NK T cells, a marker associated with activation" [MGI:Saran]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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